Iowa State vs Purdue Prediction 12/6/2025 Today’s College Basketball Picks

In this article we will formulate an Iowa State vs Purdue prediction for this College Basketball game on Saturday, December 6th at Mackey Arena in West Lafayette, Indiana. Let’s take a look at the prediction for this College Basketball matchup.

Iowa State Cyclones Betting Preview

The Iowa State Cyclones are 8-0 this season after they defeated Alcorn State by a score of 132-68 in their last game. Iowa State led 65-28 at halftime and added 67 points in the second half for the easy win. The Cyclones shot 71% from the field, 73% on three pointers, and 75% on free throws in the game. Milan Momcilovic led Iowa State with 27 points and three rebounds, while Jamarion Batemon added 26 points and four rebounds in the win. 

Prior to that game, Iowa State defeated Syracuse by a score of 95-64 and Creighton by a score of 78-60. The Cyclones have scored 96.3 points per game with 36.4 rebounds and 19.3 assists per game, while they have allowed 65.4 points against per game this season. Tamin Lipsey (questionable) is averaging 18.4 points and 5.2 assists per game, while Joshua Jefferson is averaging 18.4 points and 7.3 rebounds per game for the Cyclones. Iowa State is shooting 55% from the field, 69.5% on free throws, and 43.3% on three pointers this season. 

Purdue Boilermakers Betting Preview

The Purdue Boilermakers are 8-0 this year after they defeated Rutgers by a score of 81-65 in their last game. Purdue led 40-27 at halftime and added 41 points in the second half to secure the victory. The Boilermakers shot 47% from the field, 38% on three pointers, and 85% on free throws in the game. Trey Kaufman-Renn led Purdue with 19 points and 13 rebounds, while Braden Smith added 16 points and eight assists in the win. 

Prior to that game, Purdue defeated Eastern Illinois by a score of 109-62 and Texas Tech by a score of 86-56. The Boilermakers have scored 88.6 points per game with 40.9 rebounds and 20.6 assists per game, while they have allowed 67.6 points against per game this season. Fletcher Loyer is averaging 15.6 points and 2.4 rebounds per game, while Trey Kaufman-Renn is averaging 15.5 points and 11.0 rebounds per game for the Boilermakers. Purdue is shooting 51% from the field, 77.3% on free throws, and 41.8% on three pointers this year. 

Why the Purdue Boilermakers will win

• Purdue has won each of its last 17 day games against non-Conference opponents at Mackey Arena.
• Iowa State has lost each of its last three day games against Top 5 AP-ranked opponents.
• Iowa State has lost the first half in 13 of its last 16 games against the Big Ten Conference.

Why the Iowa State Cyclones will win

• Iowa State has won each of its last eight games against non-Conference opponents.
• Purdue has lost three of its last four day games against AP-ranked opponents.
• Purdue has lost the first half in three of its last four day games against AP-ranked opponents.

Total Points Facts

• Seven of Iowa State’s last eight day games against Top 5 AP-ranked opponents have produced a total of 149 or fewer points.
• Six of Purdue’s last seven games against the Big 12 Conference Conference have produced a total of 148 or fewer points.

Iowa State vs Purdue Prediction 

Both of these teams come into this matchup with 8-0 records to start the season, but Purdue will have the home court advantage. Purdue is shooting 51% from the field and they have scored at least 80 points in five straight. Iowa State is shooting 55% from the field and they have scored at least 83 points in four of their last five. The Cyclones are dealing with an injury to one of their best players, but they are a pretty deep team and they can score with the best of them. Take Iowa State and the points here.

David Racey's Pick: Iowa State +5.5