Eastern Illinois vs Southern Indiana Prediction 1/22/2026 Today’s College Basketball Picks

The Eastern Illinois Panthers and the Southern Indiana Screaming Eagles meet Thursday in college basketball action from Liberty Arena. Here’s a Eastern Illinois vs Southern Indiana prediction. We will look at this from a betting perspective and determine the best Eastern Illinois vs Southern Indiana pick. We will examine the recent form and player performances for both teams, as well as the recent betting trends and streaks pertaining to this matchup. As we conclude, we will tie it all together with a summary that produces a sensible pick for a favorable betting outcome in this game.

Eastern Illinois Panthers Betting Preview

The Panthers were only able to win two of their first 10 games this year over Nicholls and Tiffin. Since then Eastern Illinois has been a lot better on a 6-3 stretch. The wins in that time have come courtesy of SIU Edwardsville, East-West U, Tennessee Tech, Tennessee State, Western Illinois and Blackburn. Over 19 games so far this year that gives the Panthers an 8-11 overall record in the books.

In the Blackburn game on Sunday the Panthers went into the second half with a 53-26 advantage. Eastern Illinois hit a 52-23 run the rest of the way and took the win in the end 105-49. Zion Fruster was tops on 16 points with five rebounds and two assists while Andre Washington had 16 points as well alongside his two assists and one rebound in 19 minutes of action.

Southern Indiana Screaming Eagles Betting Preview

Over on the Eagles’ side, they managed to win three of their first eight games this year. It’s only gotten worse for Southern Indiana since then though, as they’re 1-9 in their last 10 with losses to Western Michigan, Indiana State, Little Rock, Morehead State, SIU Edwardsville, Lindenwood, Southeast Missouri State, TN-Martin and Tennessee State. That gives the Eagles a 4-14 record in 18 games this year.
In the Tennessee State matchup on Saturday the Eagles entered the second half with a five-point deficit 38-33. Southern Indiana didn’t end up getting any closer on a 35-34 run from there and lost the game 73-67 in the end. Amaree Brown was the lead scorer on the team with 20 points and five rebounds in 28 minutes. Cardell Bailey doubled up on 19 points with 10 rebounds as well.

Eastern Illinois Panthers @ Southern Indiana Screaming Eagles Betting Trends: January 22, 2026

Why the Southern Indiana Screaming Eagles will win

• Eastern Illinois has lost 13 of its last 14 away games when playing with a rest disadvantage.
• The home team has won 19 of Eastern Illinois’ last 21 games.

Why the Eastern Illinois Panthers will win

• Southern Indiana has lost nine of its last 10 games against non-AP-ranked opponents.
• Eastern Illinois has won four of its last five games against non-AP-ranked opponents.
• Southern Indiana has lost the first half in three of its last four games against non-AP-ranked opponents.

Eastern Illinois vs Southern Indiana Prediction

I’ll stay with Eastern Illinois but I’m probably not touching this one. The Panthers didn’t have much issue with an overmatched Blackburn team in their last game, shooting a cool 67.7 percent from the field and 50 percent (10-of-20) from outside along with a 32-15 advantage on the boards and a 56-8 edge on points in the paint. EIU is on a pretty good run these days with four wins in the last five games. The Panthers have 71 or more points in three of the four wins as well.

As for Southern Indiana, they’re coming off another road loss to a pretty good Tennessee State team. The Eagles shot just 38.5 percent from the field in that one with 12 turnovers and a 42-20 deficit on points in the paint. Southern Indiana has won just one game in the last 10 however, and they’ve been below 68 points in two of the last three.

Andrew Jett's Pick: Eastern Illinois Panthers +3