Eastern Illinois vs Iowa State Prediction 12/14/2025 Today’s College Basketball Picks

The Eastern Illinois Panthers and the Iowa State Cyclones meet Sunday in college basketball action from the Hilton Coliseum. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Eastern Illinois Panthers vs. Iowa State Cyclones prediction.

Eastern Illinois Panthers Recap

The Eastern Illinois Panthers come into this game looking to shake off a 68-59 loss at the hands of Eastern Kentucky last time out to sit at 2-7 this season. After this game, Eastern Illinois will head home for a game against SIU Edwardsville.

Panthers Lose 4th In A Row

Zion Fruster has 16.6 PPG with 3.6 RPG and 2 APG in 5 games played so far this season while Kooper Jacobi has 11.1 PPG with 5.6 RPG and a team-high 2.4 APG to lead the Panthers in assists. Terry McMorris has 10.6 PPG with a team-high 6.5 RPG to lead the Panthers in rebounding and to cap off the trio of double-digit scorers for Eastern Illinois so far this season. Preston Turner has 9.7 PPG while Meechie White has 9.5 PPG with 3.1 RPG and 2.4 APG as well this season. As a team, Eastern Illinois is averaging 62.1 PPG on 41% shooting from the field, 27.6% from three and 73.5% from the foul line this season.

Iowa State Cyclones Recap

The Iowa State Cyclones come into this game looking to add on to their 66-62 win over Iowa last time out to sit at 10-0 on the year. After this game, Iowa State will take on Long Beach State at home.

Cyclones Looking To Stay Unbeaten

Joshua Jefferson leads the Cyclones with 18.2 PPG, 6.5 RPG and 5 APG while Milan Momcilovic has 17.5 PPG with 3 RPG and Tamin Lipsey has 16.4 PPG with 3.4 RPG and 5.4 APG along with 2.9 SPG. Killyan Toure has 11.5 PPG with 2.2 SPG to cap off the group of double-digit scorers for Iowa State so far this season.  Dominick Nelson has 6.6 PPG and Blake Buchanan has 8.6 PPG with 5.7 RPG as well this season. As a team, Iowa State is averaging 91.7 PPG on 53.8% shooting from the field, 43.1% from three and 69.9% from the foul line this season. 

Eastern Illinois Panthers @ Iowa State Cyclones Betting Trends: December 14, 2025

Why the Iowa State Cyclones will win

• Iowa State has won each of its last 39 games against non-Conference opponents at James H. Hilton Coliseum.
• Eastern Illinois has lost eight of its last nine games against non-Conference opponents.
• Iowa State has won the first half in each of its last 18 day games against non-Conference opponents at James H. Hilton Coliseum.

Total Points Facts

• Five of Iowa State’s last six day games against non-Conference opponents at James H. Hilton Coliseum have produced a total of 154+ points.
• Fourteen of Eastern Illinois’ last 17 games have produced a total of 141 or fewer points.

Matchup/League Facts

• Iowa State ranks 1st among Division 1 teams for field goal percentage this season (53.8%).
• Iowa State ranks 2nd among Division 1 teams for point differential per game this season (+27.4).
• Eastern Illinois ranks 363rd among Division 1 teams for three-point field goals made per game this season (4.7).
• Eastern Illinois ranks 359th among Division 1 teams for points per game this season (61.8).

Eastern Illinois Panthers vs. Iowa State Cyclones Prediction

I’m on Iowa State here. This is a huge number for the Cyclones off of the rivalry win over Iowa, but they’ve drilled all of these inferior opponents that they’ve played up to this point and I think this is a case of wrong place, wrong time for Eastern Illinois. Give me Iowa State in this one.

Chris Ruffolo's Pick: Iowa State -41.5