Clemson vs Duke Prediction 3/13/2026 Today’s College Basketball Picks

The Clemson Tigers and the Duke Blue Devils meet Friday in college basketball action from the Spectrum Center. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Clemson Tigers vs. Duke Blue Devils prediction.

Clemson Tigers Recap

The Clemson Tigers come into this one looking to add on to their 71-62 win over Wake Forest last time out.

Tigers Out Searching For Upset

RJ Godfrey leads the Tigers in scoring with 11.8 PPG and 5.3 RPG while Carter Welling has 10.2 PPG with 5.4 RPG to lead Clemson in rebounding to cap off the pair of double-digit scorers for Clemson this season. Jestin Porter has 9.6 PPG so far this season. Dillon Hunter has 7.6 PPG with 3.8 RPG and 3 APG to lead the Tigers in assists. Nick Davidson has 9.3 PPG with 4.1 RPG and Ace Buckner has 8.4 PPG with 2.8 RPG. As a team, Clemson is averaging 74.5 PPG on 45.7% shooting from the field, 34.3% from three and 72.4% from the foul line this season.

Duke Blue Devils Recap

The Duke Blue Devils come into this game looking to add on to their 80-79 win over Florida State last time out.

Blue Devils Escape Seminoles

Cameron Boozer leads Duke across the board with 22.6 PPG, 10 RPG and 4 APG while Isaiah Evans has 14.6 PPG with 2.9 RPG and Patrick Ngongba II has 10.7 PPG with 6 RPG to cap off the trio of double-digit scorers for Duke up to this point in the year. Caleb Foster has 8.6 PPG with 3.7 RPG and 2.9 APG and Cayden Boozer has 6.4 PPG with 2.8 APG as well this season. As a team, Duke is averaging 83.2 PPG on 49.9% shooting from the field, 35.5% from three and 72.7% from the foul line this season.

Clemson Tigers @ Duke Blue Devils Betting Trends: March 13, 2026

Why the Duke Blue Devils will win

• Duke has won each of its last 31 games against non-AP-ranked opponents.
• Clemson has lost three of its last four games against AP-ranked opponents at a neutral venue.
• Duke has won the first half in 20 of its last 21 night games as a top-5 AP-ranked team.

Why the Clemson Tigers will win

• Clemson has won each of its last four night games against Top 5 AP-ranked opponents.
• Clemson has won the first half in each of its last five games played at neutral venues.

Total Points Facts

• Each of Duke’s last nine games against non-AP-ranked opponents at a neutral venue have produced a total of 135+ points.
• Each of Clemson’s last seven night games against Top 5 AP-ranked opponents have produced a total of 136+ points.

Matchup/League Facts

• Duke ranks 1st among Division 1 teams for point differential per game this season (+20.5).
• Duke ranks 1st among Division 1 teams for defensive rating this season (93.5).
• Clemson ranks 7th among Division 1 teams for opponent assists per game this season (10.5).
• Clemson ranks 17th among Division 1 teams for opponent field goals made per game this season (22.6).

Clemson Tigers vs. Duke Blue Devils Prediction

I’m on Clemson here. I get the case to be made for the Blue Devils who will want to not leave things as much to chance after narrowly edging out FSU on Thursday, but the Tigers are a team that can bang with the Dukies here and I think the Blue Devils could get upset here. Give me Clemson.

Chris Ruffolo's Pick: Clemson +11.5