Chicago State vs St. Louis Prediction 11/6/2025 Today’s College Basketball Picks

The Chicago State Cougars and the Saint Louis Billikens meet Thursday in college basketball action from the Chaifetz Arena. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago State Cougars vs. Saint Louis Billikens prediction.

Chicago State Cougars Recap

The Chicago State Cougars come into this game looking to rebound from a 92-62 loss at the hands of the Depaul Blue Demons last time out to start the year at 0-1. 

Cougars Looking To Rebound

Stephen Byard leads the Cougars with 16 points on 5 of 8 shooting while Marcus Tankersley had 16 points with a team-high 9 rebounds, shooting 6 of 11 from the floor. Doyel Cockrill III added 10 points to cap off the trio of double-digit scorers for Chicago State in the losing effort. CJ Ray added 4 points to match his 4 rebounds while Braelon Bush added 6 points with 4 rebounds, 3 assists and 2 steals as well in the loss.

Saint Louis Billikens Recap

The Saint Louis Billikens come into this game looking to add on to their season-opening 92-67 win over SE Missouri State last time out to start the year at 1-0. 

Billikens Looking To Remain Unbeaten

Robbie Avila led the Billikens with 18 points on 6 of 13 shooting with 3 threes and 11 rebounds for the double-double while Amari McCottry added 16 points on 7 of 8 shooting. Kellen Thames added 12 points with 4 rebounds, a team-high 3 assists and 3 steals as well in the win. Dion Brown chipped in 11 points with 11 rebounds and 3 assists for his own double-double and Quentin Jones added 10 points with 7 rebounds to cap off the group of double-digit scorers for Saint Louis in the winning effort. 

Chicago State Cougars @ Saint Louis Billikens Betting Trends: November 6, 2025

Why the Saint Louis Billikens will win

• Chicago State has lost each of its last 17 games against non-Conference opponents.
• Saint Louis has won eight of its last nine home games against non-Conference opponents.
• Chicago State has lost the first half in each of its last 10 night games against non-Conference opponents.

Why the Chicago State Cougars will win

• Saint Louis has lost four of its last five games against non-Conference opponents.
• Saint Louis has lost the first half in four of its last five night games at Chaifetz Arena.

Total Points Facts

• Each of Saint Louis’ last six Thursday games against non-Conference opponents have produced a total of 149 or fewer points.
• Thirty of Chicago State’s last 37 games against non-Conference opponents have produced a total of 152 or fewer points.

Chicago State Cougars vs. Saint Louis Billikens Prediction

I’m on the Billikens here. It’s a big number, but one that I do think that the Billikens will be able to cover as they’re simply the better and more complete team in this matchup. Chicago State is a team I’m going to keep my eye on this season with a new head coach and a new identity, but I think that Saint Louis ends up being too much here. Give me the Billikens.

Chris Ruffolo's Pick: St. Louis -28.5