UCLA vs USC Prediction 11/29/2025 Today’s College Football Picks

The UCLA Bruins and USC Trojans meet Saturday in college football action at Los Angeles Memorial Coliseum. Here’s a UCLA vs USC Prediction. This article will include a UCLA vs USC Pick.

UCLA Bruins Betting Preview

The UCLA Bruins lost to Ohio State and Washington. UCLA has lost 4 straight games. Nico Iamaleava is completing 63.5 percent of his passes for 1,728 yards, 12 touchdowns, and 7 interceptions. Kwazi Gilmer and Mikey Matthews have combined for 772 receiving yards and 5 touchdowns, while Titus Mokiao-Atimalala has 21 receptions. The UCLA Bruins ground game is averaging 156.7 yards per contest, and Nico Iamaleava leads the way with 490 yards and 4 touchdowns. Defensively, UCLA is allowing 37.2 points and 425.6 yards per game. JonJon Vaughns leads the UCLA Bruins with 102 tackles, Anthony Jones has 1.5 sacks and Scooter Jackson has 2 interceptions.

USC Trojans Betting Preview

The USC Trojans beat Iowa and lost to Oregon. The USC Trojans have won 3 of their last 4 games. Jayden Maiava is completing 65.7 percent of his passes for 3,174 yards, 21 touchdowns and 8 interceptions. Makai Lemon and Ja’Kobi Lane have combined for 1,817 receiving yards and 14 touchdowns, while Lake McRee has 27 receptions.

The USC Trojans ground game is averaging 196 yards per contest, and King Miller leads the way with 749 yards and 5 touchdowns. Defensively, USC is allowing 25.9 points and 387.7 yards per game. Desman Stephens II leads the USC Trojans with 77 tackles, Braylan Shelby has 3.5 sacks and Bishop Fitzgerald has 5 interceptions.

Why the USC Trojans will win

• USC has won each of its last nine home games against non-AP-ranked teams.
• UCLA has lost each of its last seven November games against AP-ranked teams.
• UCLA has failed to cover the spread in seven of its last eight games in California.
• USC has covered the spread in nine of its last 11 games as a favorite in California.
• USC has won the first half in three of its last four games against conference opponents at United Airlines Field at the Los Angeles Memorial Coliseum.

Why the UCLA Bruins will win

• UCLA has won nine of its last 12 games against teams from California.
• USC has failed to cover the spread in four of its last five games as a favorite against non-AP-ranked teams.
• The road team has covered the spread in seven of the last nine games between UCLA and USC.

Total Points Facts

• Nine of UCLA’s last 10 games against teams from California have gone UNDER the total points line.
• Six of USC’s last seven November games against non-AP-ranked teams have gone UNDER the total points line.

USC Trojans Player Prop Facts

• Heading into Week 14, Makai Lemon ranks 3rd amongst FBS players for receiving yards (1124) this season.

UCLA Bruins Player Prop Facts

• Heading into Week 14, Mateen Bhaghani ranks T5th in the Big Ten Conference for made field goals (15) this season.

Matchup/League Facts

• USC ranks T7th among FBS teams for red zone percentage against this season (71.4).
• USC ranks 8th among FBS teams for yards per game this season (479.2).
• UCLA ranks T131st among FBS teams for average point differential in first quarters this season (-5.5).
• UCLA ranks 129th among FBS teams for H1 points per game this season (8.0).

UCLA vs USC Prediction

Right when it looked like UCLA had turned the corner, it’s gone back to stinking up the joint on both sides of the ball. UCLA has also covered just 3 games this season. USC should have a field day offensively in this spot against a UCLA defense that’s 94th in total defense and 126th in scoring defense. USC has covered 6 of its last 8 games as a double-digit favorite. Massive line for a rivalry, but UCLA is back in awful form and if that continues, this game won’t be competitive. Give me USC in a home beat down.

Randy Chambers's Pick: USC -22.5