Northwestern vs Illinois Prediction 11/29/2025 Today’s College Football Picks

In this article, we will formulate a Northwestern vs Illinois Prediction for this College Football Week 14 game on Saturday, November 29th. Let’s take a look at the prediction for this College Football matchup.

Illinois Fighting Illini Preview

Illinois has a 7-4 record this season and is sitting 9th in the Big Ten. They are 7-3 ATS, 5-5 in Over/Under and have a 5-1 home record and a 2-2 away record. Illinois is coming off a 10-27 road loss against Wisconsin.

Offensively, Illinois averages 30.2 points per game, ranking 48th in the nation, while defensively, they allow 24.2 points per game, which is 64th. Illinois averages 378.1 total yards per game (245.9 passing and 132.2 rushing), while allowing 359.3 total yards per game (127.0 rushing and 232.3 passing).

Luke Altmyer leads Illinois with 2,675 passing yards with 68.1% completed passes and 21 touchdowns. Kaden Feagin leads the team in rushing yards with 486, while Hank Beatty has a team-high 61 receptions for 805 receiving yards. Defensively, Matthew Bailey has a team-high 70 total tackles (55 of them solo), while Gabe Jacas leads the team in sacks, with 9, and Miles Scott, Dylan Rosiek, Tanner Heckel have a team-high 1 interception each.

Northwestern Wildcats Preview

Northwestern has a 6-5 record this season and is sitting 10th in the Big Ten. They are 6-3-1 ATS, 4-6 in Over/Under and have a 4-2 home record and a 1-3 away record. Northwestern is coming off a 38-35 home win against Minnesota.

Offensively, Northwestern averages 23.4 points per game, ranking 101st in the nation, while defensively, they allow 21.0 points per game, which is 35th. Northwestern averages 357.5 total yards per game (183.5 passing and 174.0 rushing), while allowing 339.5 total yards per game (141.8 rushing and 197.6 passing).

Preston Stone leads Northwestern with 2,011 passing yards with 60.7% completed passes and 13 touchdowns. Caleb Komolafe leads the team in rushing yards with 886, while Griffin Wilde has a team-high 56 receptions for 755 receiving yards. Defensively, Robert Fitzgerald has a team-high 98 total tackles (62 of them solo), while Aidan Hubbard leads the team in sacks, with 4, and Mac Uihlein has a team-high 4 interceptions.

Northwestern Wildcats @ Illinois Fighting Illini Betting Trends: Week 14

Why the Illinois Fighting Illini will win

• Illinois has won each of its last nine games as a favorite in Illinois.
• Northwestern has lost each of its last six games as an underdog in Illinois.
• Illinois has covered the spread in each of its last six games as a favorite in Illinois.
• Northwestern has failed to cover the spread in four of its last five road games.
• Northwestern has lost the first half in each of its last four games against conference opponents.

Why the Northwestern Wildcats will win

• Northwestern has won three of its last four November games as an underdog against non-AP-ranked teams.
• Northwestern has covered the spread in four of its last five November road games against non-AP-ranked teams.

Total Points Facts

• Seven of Northwestern’s last eight games in November have gone OVER the total points line.
• Seven of the last eight November games between Northwestern and Illinois have gone OVER the total points line.

Illinois Fighting Illini Player Prop Facts

• Heading into Week 14, Gabe Jacas ranks T12th amongst FBS players for sacks (9.0) this season.

Northwestern Wildcats Player Prop Facts

• Heading into Week 14, Mac Uihlein ranks T10th amongst FBS players for interceptions (4) this season.

Matchup/League Facts

• Illinois ranks T127th among FBS teams for interceptions this season (3).
• Illinois ranks T117th among FBS teams for red zone percentage against this season (89.5).
• Northwestern ranks 13th among FBS teams for time of possession per game this season (32:55).
• Northwestern ranks 14th among FBS teams for red zone percentage this season (92.7).

Northwestern vs Illinois Prediction

In this Northwestern vs Illinois Prediction, Illinois is coming as -7-point home favorites. Illinois has more wins this season and have been almost perfect at home, while on the other hand, Northwestern is terrible on the road. Both teams have been very good against the spread and are both playing very good defense, holding their opponents into just 45.2 points per game combined. Northwestern’s offense has also been terrible lately, having scored 22 points or less in 5 of its last 6 games, so I expect a low-scoring affair today. Take the under 46.5 points in this one.

Nikos Lagouretos's Pick: Under 46.5