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Missouri vs Vanderbilt Prediction 10/25/2025 Today’s College Football Picks
Pick details
Missouri (6-1) vs Vanderbilt (6-1)
October 25, 2025 at 03:30 PM EDT
The Line: Betting Odds: Vanderbilt -2.5 — Over/Under: +51.5
The Missouri Tigers and Vanderbilt Commodores meet Saturday in college football action at FirstBank Stadium. Here’s a Missouri vs Vanderbilt Prediction. This article will include a Missouri vs Vanderbilt Pick.
The Missouri Tigers beat Auburn, lost to Alabama, and they play Texas A&M next. The Missouri Tigers have won 9 of their last 10 games. Beau Pribula is completing 70 percent of his passes for 1,617 yards, 11 touchdowns, and 7 interceptions. Marquis Johnson and Kevin Coleman Jr. have combined for 771 receiving yards and 3 touchdowns, while Brett Norfleet has 25 receptions.
The Missouri Tigers ground game is averaging 244.9 yards per contest, and Ahmad Hardy leads the way with 840 yards and 11 touchdowns. Defensively, Missouri is allowing 16.7 points and 243 yards per game. Josiah Trotter leads the Missouri Tigers with 44 tackles, Damon Wilson II has 5.5 sacks and Dante McClellan has 1 interception.
The Vanderbilt Commodores beat LSU, lost to Alabama, and they play Texas next. The Vanderbilt Commodores have 7 of their last 8 games. Diego Pavia is completing 70.5 percent of his passes for 1,569 yards, 15 touchdowns, and 4 interceptions. Eli Stowers and Junior Sherrill have combined for 659 receiving yards and 7 touchdowns, while Tre Richardson has 20 receptions.
The Vanderbilt Commodores ground game is averaging 213 yards per contest, and Diego Pavia leads the way with 438 yards and 4 touchdowns. Defensively, Vanderbilt is allowing 20 points and 315 yards per game. CJ Heard leads the Vanderbilt Commodores with 35 tackles, Miles Capers has 4.5 sacks and Martel Hight has 1 interception.
Vanderbilt is legit with a star at quarterback and an udneratted defense, so I’m not surprised they’re favored at home. However, the value is with Missouri and the free points. Missouri is a top-10 rushing team and one of the best defenses in the country. Missouri is built to win on the road and is sure to have a game plan to slow down Pavia and all of his hype. These are two solid teams overall, so whichever team was getting points would have been the side I was on. Either team winning wouldn’t be surprising. Just don’t sleep on Missouri, is all I’m saying. Give me the points.
Missouri Tigers Betting Preview
The Missouri Tigers beat Auburn, lost to Alabama, and they play Texas A&M next. The Missouri Tigers have won 9 of their last 10 games. Beau Pribula is completing 70 percent of his passes for 1,617 yards, 11 touchdowns, and 7 interceptions. Marquis Johnson and Kevin Coleman Jr. have combined for 771 receiving yards and 3 touchdowns, while Brett Norfleet has 25 receptions.
The Missouri Tigers ground game is averaging 244.9 yards per contest, and Ahmad Hardy leads the way with 840 yards and 11 touchdowns. Defensively, Missouri is allowing 16.7 points and 243 yards per game. Josiah Trotter leads the Missouri Tigers with 44 tackles, Damon Wilson II has 5.5 sacks and Dante McClellan has 1 interception.
Vanderbilt Commodores Betting Preview
The Vanderbilt Commodores beat LSU, lost to Alabama, and they play Texas next. The Vanderbilt Commodores have 7 of their last 8 games. Diego Pavia is completing 70.5 percent of his passes for 1,569 yards, 15 touchdowns, and 4 interceptions. Eli Stowers and Junior Sherrill have combined for 659 receiving yards and 7 touchdowns, while Tre Richardson has 20 receptions.
The Vanderbilt Commodores ground game is averaging 213 yards per contest, and Diego Pavia leads the way with 438 yards and 4 touchdowns. Defensively, Vanderbilt is allowing 20 points and 315 yards per game. CJ Heard leads the Vanderbilt Commodores with 35 tackles, Miles Capers has 4.5 sacks and Martel Hight has 1 interception.
Why the Vanderbilt Commodores will win
- Vanderbilt has won each of its last 10 games as a home favorite.
- Missouri has lost 13 of its last 14 games against top-10 AP-ranked teams.
- Vanderbilt has covered the spread in each of its last four October home games against AP-ranked teams.
- Missouri has failed to cover the spread in four of its last five games against AP-ranked teams.
Why the Missouri Tigers will win
- Missouri has won eight of its last nine games against Vanderbilt.
- Vanderbilt has lost 20 of its last 23 home games against conference opponents.
- Vanderbilt has failed to cover the spread in five of its last six October games as a home favorite.
- The road team has covered the spread in each of the last three games between Missouri and Vanderbilt.
Total Points Facts
- Eleven of Vanderbilt’s last 13 games as a favorite have gone OVER the total points line.
- Five of Missouri’s last six October games against top-15 AP-ranked teams have gone UNDER the total points line.
Vanderbilt Commodores Player Prop Facts
- Heading into Week 9, Sedrick Alexander ranks T5th amongst FBS players for touchdowns (10) this season.
Missouri Tigers Player Prop Facts
- Heading into Week 9, Ahmad Hardy ranks 2nd amongst FBS players for rushing touchdowns (11) this season.
Matchup/League Facts
- Vanderbilt ranks T7th among FBS teams for Q2 points per game this season (13.3).
- Vanderbilt ranks 7th among FBS teams for Q3 points per game this season (10.3).
- Missouri ranks 3rd among FBS teams for 1st downs this season (186).
- Missouri ranks T3rd among FBS teams for average point differential in fourth quarters this season (+7.3).
Missouri vs Vanderbilt Prediction
Vanderbilt is legit with a star at quarterback and an udneratted defense, so I’m not surprised they’re favored at home. However, the value is with Missouri and the free points. Missouri is a top-10 rushing team and one of the best defenses in the country. Missouri is built to win on the road and is sure to have a game plan to slow down Pavia and all of his hype. These are two solid teams overall, so whichever team was getting points would have been the side I was on. Either team winning wouldn’t be surprising. Just don’t sleep on Missouri, is all I’m saying. Give me the points.
