Clemson vs Pittsburgh Prediction College Football Picks 11/16/24

Pick details

Pittsburgh (7-1) vs Clemson (6-2)

November 16, 2024 at 12:00 PM EST

The Line: Betting Odds: Pittsburgh +10 / Clemson -10 — Over/Under: 59.5

(Get latest betting odds)

The Clemson Tigers and the Pitt Panthers meet in week 12 college football action from Acrisure Stadium on Saturday afternoon. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Clemson vs. Pitt prediction.

Clemson Recap

The Clemson Tigers come into this one looking to build on their 24-14 win over Virginia Tech last time out. After this game, Clemson will head home for a non-conference date with the Citadel.

Tigers Looking To Give Themselves Shot In ACC Title Hunt

Cade Klubnik has thrown for 2,275 yards, 24 touchdowns, and 4 interceptions on 63.1% passing while also rushing for 300 yards and 4 touchdowns. Phil Mafah has a team-high 981 rushing yards with 8 TDs while Antonio Williams leads the Clemson receiving group with 40 receptions for 468 yards and 6 TDs and Bryant Wesco Jr. has 19 grabs for 332 yards and 2 scores. Jake Briningstool has 35 receptions for 388 yards and 5 TDs while four more Tigers have 100+ receiving yards as well on the year. On defense, Wade Woodaz has a team-high 61 total tackles including 33 solo tackles while T.J. Parker has a team-high 5 sacks and Sammy Brown has 4 sacks. As a unit, Clemson has combined for 18 sacks and 11 interceptions so far this season.

Why the Clemson Tigers will win

  • Clemson has won 13 of its last 14 November road games against non-AP-ranked teams.
  • Pittsburgh has lost five of its last six games in November.
  • Clemson has covered the spread in seven of its last eight November road games against non-AP-ranked teams.
  • Pittsburgh has failed to cover the spread in four of its last five games in November.

Pitt Recap

The Pitt Panthers come into this one looking to bounce back from back-to-back losses after a 24-19 loss to Virginia last time out. After this game, Pitt will head on the road for a matchup against Louisville.

Panthers Looking To Show Out On Senior Day

Eli Holstein has thrown for 2,174 yards, 17 touchdowns, and 6 interceptions on 61.9% passing while Desmond Reid has rushed for a team-high 670 yards and 4 touchdowns. Konata Mumpfield has a team-high 35 receptions for 560 yards and 3 touchdowns for Pitt’s receiving group while Kenny Johnson has 391 receiving yards with 3 touchdowns. Desmond Reid has 428 receiving yards and 4 touchdowns while Censere Lee and Raphael Williams Jr. each have 250+ receiving yards on the year as well. On defense, Donovan McMillon has a team-high 77 total tackles while Rasheem Biles, Jimmy Scott, and Kyle Louis each have 5 sacks with Louis logging a team-high 4 interceptions. As a unit, Pitt has a team-high 30 sacks and 12 interceptions.

Why the Pittsburgh Panthers will win

  • Pittsburgh has won three of its last four November games as a home underdog.
  • Pittsburgh has covered the spread in each of its last four November games as a home underdog.

Clemson vs. Pitt Prediction

I’m leaning towards Clemson here. I get the allure of backing Pitt as a home underdog on senior day, but the Panthers played with fire often this season and it’s started to get them burned like it did against SMU and Virginia. Clemson doesn’t have another conference game after this so I expect the Tigers to show up in a big way here to give themselves the best chance at controlling their own fate. Give me Clemson.

Chris Ruffolo's Pick: Clemson -10

Need More? Get Premium Picks

Hot Cappers

Latest Picks & Game Previews

  • Manchester City vs Brighton & Hove Albion Prediction 8/31/2025 Today’s EPL Picks

    August 31, 2025

  • West Ham United vs Nottingham Forest Prediction 8/31/2025 Today’s EPL Picks

    August 31, 2025

  • Arsenal FC Arsenal FC vs Liverpool Liverpool Prediction 8/31/2025 Today’s EPL Picks

    August 31, 2025

  • Cardinals vs Reds Prediction 8/31/2025 Today’s MLB Picks

    August 31, 2025

  • San Diego Padres vs Minnesota Twins Prediction 8/31/2025 Today’s MLB Picks

    August 31, 2025

  • Brewers vs Blue Jays Prediction 8/31/2025 Today’s MLB Picks

    August 31, 2025

  • Mariners vs Guardians Prediction 8/31/2025 Today’s MLB Picks

    August 31, 2025

  • Crystal Palace vs Aston Villa Prediction 8/31/2025 Today’s EPL Picks

    August 31, 2025

  • Virginia Tech vs South Carolina Prediction 8/31/2025 Today’s College Football Picks

    August 31, 2025

  • Notre Dame vs Miami (FL) Prediction 8/31/2025 Today’s College Football Picks

    August 31, 2025