Tennessee Titans vs Indianapolis Colts Prediction 10/26/2025 Today’s NFL Picks

The Tennessee Titans and the Indianapolis Colts meet Sunday in NFL action from Lucas Oil Stadium. Here’s a Titans vs Colts prediction. We will look at this from a betting perspective and determine the best Titans vs Colts pick. We will examine:

The Tennessee Titans recent form and player performance

The Indianapolis Colts recent form and player performance

Recent betting trends and streaks involving the Tennessee Titans

Recent betting trends and streaks involving the Indianapolis Colts

Recent betting trends in games played between the Titans and Colts

A summary that ties it all together and produces a favorable betting outcome for the Titans vs Colts game

Tennessee Titans Betting Preview

Tennessee has had a pretty rough year so far—to put it mildly. The Titans opened the season on a four-game skid, falling to the Denver Broncos, the Los Angeles Rams, the Indianapolis Colts and the Houston Texans in succession. Win number one came on October 5 by one point over the Arizona Cardinals, but then Tennessee fell to the Las Vegas Raiders in the next game. In that one the Titans offense had just 225 yards, 15 first downs, 3-of-13 on third-down tries and three takeaways. otherwise the defense wasn’t too bad on the other side.

In their latest outing last weekend versus the New England Patriots, the Titans were back in the loss column. Tennessee gave up 14 points in both the second and third quarters during a 31-13 loss at home. QB Cameron Ward was 25-of-34 for 255 yards, one TD and one pick, while leading rusher Tyjae Spears had just 22 yards on five totes. Chimere Dike was the team’s leading receiver with four catches for 70 yards and a TD in the losing effort.

Indianapolis Colts Betting Preview

Over on the Colts’ side, they opened up the season on a pretty good run. Indianapolis took out the Miami Dolphins, Denver Broncos and Tennessee Titans during a 3-0 stretch, then feel to the Rams in game four. After a win over the Las Vegas Raiders, Indy took out the Arizona Cardinals in the next game. The Colts managed 355 yards on offense in that one with 25 first downs and 4-of-8 on third-down conversion attempts.

Matched up against The Los Angeles Chargers last weekend, the Colts jumped out to a nice 23-3 advantage by halftime. Indianapolis scored 15 more points from there and held on for the road win 38-24 in the end. QB Daniel Jones went 23-of-34 for 288 yards and two scores, while Jonathan Taylor had a great day rushing with 16 carries for 94 yards and three TDs. Alec Pierce was the top man in receiving during the road victory with five catches for 98 yards.

Tennessee Titans @ Indianapolis Colts Betting Trends: Week 8

Why the Indianapolis Colts will win

The Titans have lost each of their last eight Sunday games against opponents on a winning streak.
The Colts have won each of their last 11 games as favorites against AFC opponents.
The Titans have failed to cover the spread in each of their last six October games against AFC opponents.
The Colts have covered the spread in eight of their last nine October games against AFC opponents.
The Titans have lost the first quarter in five of their last six games.
The Colts have won the first half in eight of their last nine Sunday games as home favorites.

Why the Tennessee Titans will win

The underdogs have won four of the last five games between the Titans and Colts at Lucas Oil Stadium.
The Colts have lost each of their last two Week 8 games as home favorites.
The road team has covered the spread in 11 of the Colts’ last 12 Week 8 games.
The Colts have failed to cover the spread in each of their last five Week 8 games at Lucas Oil Stadium.
The Titans have won the first quarter in three of their last four games as road underdogs against the Colts.

Total Points Facts

Each of the Titans’ last five games against the Colts following a home loss have gone OVER the total points line.
Each of the last four October games between the Titans and Colts have gone UNDER the total points line.

Titans vs Colts Prediction

I’m just going to stay with the Colts. Indianapolis played a pretty nice game versus the Chargers on the road last weekend, posting 401 total yards with 6.9 yards per play, 24 first downs and zero turnovers. The defense gave up 445 yards on the other side (391 passing) along with 6.0 yards per play and 25 first downs but did have a couple of interceptions along the way to the victory. The Colts offense is cooking during this three-game win streak with 31 or more points in each of those outings.

As for the Titans, they couldn’t do much on offense versus the Patriots. Tennessee mustered 255 yards, 16 first downs and 3-of-10 on third-down tries alongside a couple of turnovers. The defense was good on third downs (5-of-12) but it hardly mattered otherwise. The Titans have just 23 combined points in their last pair and 13 or fewer points scored in three of the last four. If the Colts play to their capabilities, there’s not much chance the Titans will be able to keep pace in this road matchup.