San Francisco 49ers vs Philadelphia Eagles Prediction 1/11/2026 Today’s NFL Picks

The San Francisco 49ers and the Philadephia Eagles meet in NFL Playoff Wild Card Round action from Levi’s Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco 49ers vs. Philadephia Eagles prediction.

San Francisco 49ers Recap

The San Francisco 49ers come into the playoffs after finishing the year with an overall record of 12-5 on the year. 

49ers Looking To Make Noise In Playoff Return

Mac Jones has thrown for 2,151 yards, 13 touchdowns and 6 interceptions on 69.6% passing while Brock Purdy has thrown for 2,167 yards, 20 touchdowns and 10 interceptions on 69.4% passing. Christian McCaffrey has a team-high 1,202 rushing yards and 10 TDs while also leading the 49ers in receiving with 102 grabs for 924 yards and 7 touchdowns. Ricky Pearsall has 528 receiving yards and 36 receptions while Kendrick Bourne has 551 receiving yards and Jauan Jennings has 643 receiving yards and 9 TDs. George Kittle also has 628 receiving yards and 57 catches along with 7 touchdowns this season. Three more 49ers have 200+ receiving yards as well on the year. On defense, Dee Winters has a team-high 101 total tackles. Bryce Huff and Clelin Ferrell each have a team-high 4 sacks. As a unit, San Francisco’s defense has combined for 20 sacks and 6 interceptions so far this season. 

Philadephia Eagles Recap

The Philadephia Eagles come into the playoffs as the reigning NFC East and Super Bowl champions after finishing the year 11-6 overall.

Eagles Begin Super Bowl Title Defense

Jalen Hurts has thrown for 3,224 yards, 25 touchdowns and 6 interceptions on 64.8% passing while also rushing for 421 yards and 8 touchdowns. Saquon Barkley leads the Eagles with 1,140 rushing yards and 7 touchdowns while DeVonta Smith has 77 grabs for 1,008 yards and 4 TDs. Dallas Goedert has 60 receptions for 591 yards and 11 touchdowns and A.J. Brown has a team-high 78 catches for 1,003 yards and 7 TDs as well this season. On defense, Zack Baun has a team-high 123 total tackles including 64 solo tackles and 3.5 sacks while Jalyx Hunt has a team-high 6.5 sacks. Moro Ojomo has 6 sacks and Jordan Davis has 4.5 sacks while Hunt also has a team-high 3 interceptions. As a unit, the Eagles’ defense as a whole has combined for 42 sacks and 12 interceptions this season.

San Francisco 49ers @ Philadelphia Eagles Betting Trends: Wild Card Round

Why the Philadelphia Eagles will win

• The Eagles have won each of their last nine Sunday games against teams that held a winning record.
• The 49ers have lost each of their last five games without Kendrick Bourne.
• The Eagles have covered the spread in each of their last seven Sunday games against teams that held a winning record.
• The 49ers have failed to cover the spread in 12 of their last 13 Sunday games against teams that held a winning record.
• The favorites have won the first half in each of the 49ers’ last 10 games.
• The Eagles have won the first quarter in 10 of their last 11 Sunday games against teams that held a winning record.
• The Eagles have scored the first touchdown in 19 of their last 20 Sunday games.

Why the San Francisco 49ers will win

• The 49ers have won each of their last six games against NFC East opponents.
• The Eagles have lost each of their last three games as favorites without Tanner McKee.
• The 49ers have covered the spread in each of their last six games against NFC East opponents.
• The Eagles have failed to cover the spread in each of their last six games as home favorites following a home loss.
• The Eagles have lost the first quarter in each of their last three games as favorites following a home loss.
• The 49ers have scored the first touchdown in four of their last five games following a loss.
• The road team has won the first half in each of the 49ers’ last six Wild Card Round games.

Total Points Facts

• Each of the 49ers’ last seven road postseason games against NFC opponents have gone UNDER the total points line.
• Each of the Eagles’ last six games without Tanner McKee have gone UNDER the total points line.

Philadelphia Eagles Player Prop Facts

• A.J. Brown has scored the last touchdown in three of the Eagles’ last four games following a loss.
• Saquon Barkley has scored two touchdowns in three of his last four appearances with his team as a favorite against NFC West opponents.
• Jalen Hurts has scored at least one touchdown in 10 of the Eagles’ last 12 games at Lincoln Financial Field against teams that held a winning record.
• Jalen Hurts has recorded 21+ completions in each of the Eagles’ last three games following a home loss.
• Jalen Hurts has recorded 230+ passing yards in eight of his last nine appearances following a loss.
• Jalen Hurts has recorded 39+ rushing yards in seven of the Eagles’ last eight games as favorites against NFC West opponents.
• Jahan Dotson has recorded 12+ receiving yards in each of the Eagles’ last four home games against NFC opponents.
• Tank Bigsby has recorded 34+ rushing and receiving yards in each of the Eagles’ last four Sunday home games.
• Heading into the Wild Card Round, Jalen Hurts has the highest passer rating in a single game (min. 10 ATT) this season (158.3 vs Vikings, Week 7).

San Francisco 49ers Player Prop Facts

• Jauan Jennings has scored at least one touchdown in five of the 49ers’ last six games.
• Brian Robinson has recorded 24+ rushing yards in each of his eight previous appearances with his team as an underdog against NFC East opponents.
• Brock Purdy has recorded 230+ passing yards in eight of his last nine road appearances against NFC opponents.
• Brock Purdy has recorded 23+ completions in three of the 49ers’ last four games.
• Kendrick Bourne has recorded 44+ receiving yards in four of his last five appearances with his team as a road underdog.
• Brian Robinson has recorded 35+ rushing and receiving yards in each of his eight previous appearances with his team as an underdog against NFC East opponents.
• Heading into the Wild Card Round, Brock Purdy has recorded the equal-most passing touchdowns in a single game this season (5 vs Colts, Week 16).

Matchup/League Facts

• Eagles – two different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into the Wild Card Round.
• Eagles – two different players have recorded 90+ rushing yards in a game this season – equal-most in the NFL, heading into the Wild Card Round.
• The 49ers ranked 32nd in the NFL in sacks (20.0) during the reg. season.
• The 49ers ranked 32nd in the NFL in total punt yards (1919) during the reg. season.

San Francisco 49ers vs. Philadephia Eagles Prediction

I’m looking at the 49ers and the points. I just think between two teams with really solid defenses, it’s the Niners’ offense that’s been far more trustworthy up to this point in the year. The Eagles have been bailed out by their defense a ton this year being outgained in so many of their games to this point and I think that this could be the same kind of deal here. Give me San Francisco and the points.

Chris Ruffolo's Pick: San Francisco +5.5