San Francisco 49ers vs Las Vegas Raiders Prediction 8/16/2025 Today’s NFL Picks

In this article, we will formulate a 49ers vs Raiders Prediction for this NFL Week 2 Preseason game on Saturday, August 16^th at the Allegiant Stadium. Let’s take a look at the prediction for this NFL matchup.

Las Vegas Raiders Preview

The Raiders had a 23-23 road tie against the Seattle Seahawks in their preseason opener last week. They got outgained by their opponents by 392-368 yards and had 65 total plays. They had 198 passing yards, 170 rushing yards, and 18/32 completed passes, while losing the turnover battle by 1-2. The Raiders went 8-15 on third down conversions and were 2-2 in the red zone. Las Vegas managed to come back off a 3-16 deficit in the second period, and with a 20-7 score in the third and fourth combined, managed to tie the game.

Aidan O’Connell led the team with 18/30 passes and 205 passing yards, Cam Miller went 6/7 with 76 yards, while Geno Smith went 1/3 with 15 yards. Chris Collier had a team-high 42 rushing yards, while Shedrick Jackson caught 4 passes for 76 yards. Defensively, Hudson Clark had total 4 tackles, Treven Ma’ae had one sack and Isaiah Pola-Mao had one interception.

The Raiders were winless in the 2024 Preseason with two losses and one tie. They lost in Minnesota by 23-24 in the opener, followed by a 12-27 home defeat by Dallas. They had a 24-24 tie with San Francisco in their final preseason game.

San Francisco 49ers Preview

The 49ers got smoked 30-9 at home by the Denver Broncos in their preseason opener last week. They got outgained by their opponents by 368-203 yards and had 53 total plays. They had 107 passing yards, 96 rushing yards, and 13/27 completed passes, while losing the turnover battle by 0-4. San Francisco led 9-0 in the opening period of the game, but blacked out in the next three periods, conceding 30 unanswered points off the Broncos.

Mac Jones went 4/7 passes and a team-high 74 passing yards, Carter Bradley went for 6/14 passes and 32 yards, while Tanner Mordecai went for 3/6 passes and 21 yards. Corey Kiner had a team-high 45 rushing yards, while Jopdan Watkins caught 3 passes for 56 yards. Defensively, Derrick Canteen had 8 total tackles, while Kalia Davis had one sack.

San Francisco had a balanced 2024 preseason with one win, one loss and one tie. They lost in Tennessee by 13-17 in the preseason opener, followed by a 16-10 home victory over New Orleans. They finished the preseason with a 24-24 tie in Las Vegas.

49ers vs Raiders Prediction

The 49ers have won four of their last five head-to-head meetings against the Raiders, but the Raiders are 3-2 against the spread. Both teams are tied 1-1 wins in their two meetings in Las Vegas, and under is 3-1 in their last 4 meetings.

In this 49ers vs RaidersPrediction, the Raidersare coming as -3.5-point home favorites. The 49ers looked awful in their preseason opener, as they looked terrible offensively, and they also deal with a handful of injuries. The Raiders managed to come back after being behind 13 points against the Seahawks, and they looked good in their first game of the preseason. Pete Carroll has a 28-21 preseason record, while on the flip side, Kyle Shanahan is sitting at .500 with a 12-12 preseason record. No way I’m going to back this 49ers team in any shape or form, and the -4.5-point spread in favor of the hosts looks more than fair. Take the Las Vegas Raiders to win and cover the spread at home in this Week 2 NFL Preseason matchup.