Aug 7, 2025; El Segundo, CA, USA; Los Angeles Chargers wide receiver Keenan Allen (13) and wide receiver Tre Harris (9) during training camp at The Bolt. Mandatory Credit: Kirby Lee-Imagn Images

New Orleans Saints vs Los Angeles Chargers Prediction 8/10/2025 Today’s NFL Picks

Pick details

New Orleans (0-0) vs Los Angeles (1-0)

August 10, 2025 at 04:00 PM EDT

The Line: Betting Odds: Los Angeles — Over/Under:

(Get latest betting odds)

In this article, we will formulate a Saints vs Chargers prediction for this NFL game on Saturday, August 10th at SoFi Stadium in Inglewood, CA. Let’s take a look at the prediction for this Week 1 matchup in the preseason.

New Orleans Saints Betting Preview

The New Orleans Saints concluded the last season with a 5-12 record, tying for third place in the NFC South standings with the Panthers. They kicked off the season with two consecutive wins, but then fell into a slump, losing the next seven games, which set a disappointing tone for the entire season. The Saints managed to secure wins against the Panthers, Cowboys, Falcons, Browns, and Giants, while suffering losses to the Eagles, Falcons, Chiefs, Buccaneers (twice), Broncos, Chargers, Panthers, Rams, Commanders, Packers, and Raiders. In 2024, New Orleans averaged 19.9 points per game, ranking 24th in the NFL, while they allowed 23.4 points per game, which was ranked 19th.

During last year’s preseason, New Orleans achieved a 1-2 record, tying for second place in the NFC South with the Panthers. The Saints emerged victorious against the Cardinals, winning 16-14 in their initial game, but they were defeated by the 49ers with a score of 16-10 and by the Titans, who won 30-27. This year, New Orleans is projected to have Spencer Rattler, Tyler Shough, and Jake Haener competing for the quarterback position.

Los Angeles Chargers Betting Preview

The Los Angeles Chargers are currently 1-0 in the preseason after their triumph over Detroit, finishing the Hall of Fame game with a score of 34-7. Los Angeles surged to a 14-0 lead in the first quarter, which was reduced to 14-7 in the second quarter, before they distanced themselves in a commanding victory. The Chargers added two field goals in the third quarter and capped off the game with a touchdown late in the fourth quarter to secure the win.

In terms of performance, Los Angeles outgained Detroit with a total of 261 yards to 197, converted 4 of 13 third-down attempts, and achieved a remarkable 5-0 turnover differential in the game. Trey Lance completed 13 passes out of 20 attempts for 120 yards and two touchdowns, while DJ Uiagalelei completed 2 of 3 passes for 25 yards. Kimani Vidal rushed for 37 yards and scored two touchdowns, and KeAndre Lambert-Smith caught two passes for 43 yards and a touchdown. Emany Johnson led the defense with seven tackles, while both Morris-Brash and Edwards contributed a sack each.

Last year, Los Angeles finished the preseason with a 1-2 record, placing them second in the AFC West. The Chargers lost their first two matchups against the Seahawks and Rams, with final scores of 16-3 and 13-9. Nevertheless, they triumphed in their last game, winning 26-19 against the Cowboys. Justin Herbert will not be taking part in this game, and it seems that Heinicke will also be sidelined, leading to the expectation of considerable playing time for Trey Lance again.

Saints vs Chargers Prediction 

As these two teams prepare for this matchup, they seek to kick off the preseason positively; however, I believe New Orleans has more motivation. The Saints plan to employ at least three quarterbacks in this game, all of whom will strive to make significant plays and advance the ball. The Chargers will have Trey Lance taking snaps, who had a commendable performance in the opening game against the Lions. I expect both offenses to be robust, which leads me to pick the Over in this scenario.

Oliver Zivic's Pick: Over 36.5

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