Miami Dolphins vs San Francisco 49ers Prediction 9/20/2026 Today’s NFL Picks

In this article, we will formulate a Dolphins vs 49ers Prediction for this NFL Week 2 game on Sunday, September 20th. Let’s take a look at the prediction for this NFL matchup.

San Francisco 49ers Preview

The San Francisco 49ers have a 1-0 record and are coming off a 27-7 neutral-site victory over the Los Angeles Rams, where they outgained their opponents 379-290 yards and had 64 total plays. San Francisco had 205 passing yards, 174 rushing yards, and 25/34 completed passes, while winning the turnover battle by 1-2. The 49ers were 7/12 on third down conversions and 2/3 in the red zone.

Brock Purdy led San Francisco with 25/34 passes, 205 passing yards, 3 touchdowns, and one interception. Christian McCaffrey had a team-high 68 rushing yards, while Demario Robinson caught 2 passes for a team-high 50 receiving yards. Defensively, Fred Warner led the 49ers with 11 total tackles, 5 of them solo.

Miami Dolphins Preview

The Miami Dolphins have a 0-1 record and are coming off a 13-27 road defeat by the Las Vegas Raiders, where they were outgained by their opponents 290-259 yards and had 50 total plays. Miami had 185 passing yards, 74 rushing yards, and 15/27 completed passes, while the turnover battle was tied at 2-2. The Dolphins were 2/10 on third down conversions and 1/3 in the red zone.

Malik Willis led Miami with 15/27 passes, 185 passing yards, and one interception. Malik Willis also had a team-high 39 rushing yards and one touchdown, while Caleb Douglas caught 5 passes for a team-high 94 receiving yards. Defensively, Jacob Rodriguez led the Dolphins with 14 total tackles, 5 of them solo.

Miami Dolphins @ San Francisco 49ers Betting Trends: Week 2

Why the San Francisco 49ers will win

• The 49ers have won each of their last 11 home games when playing with a rest advantage.
• The Dolphins have lost seven of their last eight games in September.
• The 49ers have covered the spread in each of their last four games following a Division game.
• The Dolphins have failed to cover the spread in eight of their last 10 games as road underdogs.
• The 49ers have scored the first touchdown in six of their last seven Week 2 games.
• The 49ers have won the first half in each of their last nine home games against teams that held a losing record.
• The 49ers have won the first quarter in each of their last nine home games against teams that held a losing record.

Why the Miami Dolphins will win

• The road team has won each of the Dolphins’ last nine Week 2 games.
• The 49ers have lost each of their last three games as favorites without Deebo Samuel.
• The 49ers have failed to cover the spread in 15 of their last 16 home games following a win.
• The road team has covered the spread in eight of the Dolphins’ last nine Week 2 games.
• The Dolphins have scored the first touchdown in four of their last five road games against NFC West opponents.
• The road team has won the first half in seven of the Dolphins’ last eight Week 2 games.
• The underdogs have won the first quarter in three of the last four games between the Dolphins and 49ers.

Total Points Facts

• Each of the Dolphins’ last six games without Greg Dulcich have gone OVER the total points line.
• Seven of the 49ers’ last eight home games against AFC opponents have gone OVER the total points line.
• Three of the last four Sunday games at Levi’s Stadium have gone OVER the total points line.

San Francisco 49ers Player Prop Facts

• Deebo Samuel has scored the last touchdown in four of his last five September appearances.
• Mike Evans has scored the first touchdown in three of his last four September home appearances.
• Mike Evans has scored at least one touchdown in each of his last six appearances against AFC East opponents.
• Deebo Samuel has recorded 44+ receiving yards in each of his last eight September appearances with the 49ers as favorites.
• Brock Purdy has recorded 244+ passing yards in 10 of the 49ers’ last 11 home games as heavy favorites (>-7.0 points).
• Brock Purdy has recorded 16+ rushing yards in each of his last six appearances following a road win.
• Brock Purdy has recorded 20+ completions in each of his last five Sunday home appearances.
• Deebo Samuel has recorded 52+ rushing and receiving yards in each of his last 12 September appearances with the 49ers as favorites.
• Heading into Week 2, Demarcus Robinson ranks T1st in the NFL in 20+ yard receiving touchdowns (1) this season.

Miami Dolphins Player Prop Facts

• De’Von Achane has scored two touchdowns in three of his last four appearances in day games against teams that held a winning record.
• De’Von Achane has scored at least one touchdown in eight of the Dolphins’ last nine games following a road loss.
• De’Von Achane has recorded 60+ rushing yards in 11 of his last 12 appearances.
• De’Von Achane has recorded 90+ rushing and receiving yards in 11 of his last 12 appearances.
• Jalen Tolbert has recorded 11+ receiving yards in 15 of his last 16 Sunday appearances with his team as an underdog.
• Heading into Week 2, Greg Dulcich ranks T1st amongst qualified players for catch rate (100.0%) this season.

Matchup/League Facts

• Heading into Week 2, the 49ers rank 1st in the NFL in points allowed per game (7.0) this season.
• Heading into Week 2, the 49ers rank T1st in the NFL in Q1 win percentage (100.0) this season.
• Heading into Week 2, the Dolphins have recorded the longest kickoff return this season (79 yards).
• Heading into Week 2, the Dolphins rank T1st in the NFL in average points against in fourth quarters this season (0.0).

Dolphins vs 49ers Prediction

In this Dolphins vs 49ers Prediction, the 49ers are coming as -13.5 home favorites. Both teams are coming off opposite outcomes in their opening games of the season, with the 49ers coming off a 20-point victory where they held their opponents into just 7 points. On the flip side, Miami lost on the road and will be playing their second straight game away from home to start the season and were bad on the road last season with a 2-6 record. The 49ers are 4-2 ATS in their six meetings against the Dolphins and have won their last home head-to-head meeting by 33-17. Take the 49ers and lay the -13.5 in this one.

Nikos Lagouretos's Pick: San Francisco 49ers -13.5