Los Angeles Rams vs San Francisco 49ers Prediction 11/9/2025 Today’s NFL Picks

The Los Angeles Rams and the San Francisco 49ers meet in week 10 NFL action from Levi’s Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Rams vs. San Francisco 49ers prediction.

Los Angeles Rams Recap

The Los Angeles Rams come into this game looking to build on teir 34-10 win over the New Orleans Saints last time out to sit at 6-2 this season. After this game, the Rams will head home for a game against the Seattle Seahawks.

Rams Win 3 In A Row

Matthew Stafford has thrown for 2,147 yards, 21 touchdowns and 2 interceptions on 67.2% passing while Kyren Williams has rushed for 586 yards and 3 touchdowns to lead the Rams on the ground and Blake Corum has 251 rushing yards. Puka Nacua has a team-high 61 catches for 711 yards while Davante Adams has 36 grabs for 491 yards and 8 touchdowns. Five more Rams have 100+ receiving yards as well this season. On defense, Nate Landman has a team-high 72 total tackles including 33 solo tackles. Byron Young has a team-high 9 sacks while the Rams’ defense as a whole has combined for 27 sacks and 5 interceptions so far this season.

San Francisco 49ers Recap

The San Francisco 49ers come into this game looking to build on their 34-24 win over the New York Giants last time out to sit at 6-3 this season. After this game, the 49ers will head on the road for a game against the Arizona Cardinals.

49ers Alternate Wins & Losses In 7 Straight

Mac Jones has thrown for 1,832 yards, 10 touchdowns and 5 interceptions on 67.2% passing while Brock Purdy has thrown for 586 yards, 4 touchdowns and 4 interception on 65.8% passing. Christian McCaffrey has a team-high 596 rushing yards while also leading the 49ers in receiving with 61 grabs for 626 yards and 4 touchdowns. Ricky Pearsall has 327 receiving yards and 20 receptions while Kendrick Bourne has 463 receiving yards and two more 49ers have 200+ receiving yards as well on the year. On defense, Dee Winters has a team-high 59 total tackles. As a unit, San Francisco’s defense has combined for 11 sacks and an interception so far this season. 

Los Angeles Rams @ San Francisco 49ers Betting Trends: Week 10

Why the San Francisco 49ers will win

• The 49ers have won seven of their last eight games as underdogs against the Rams.
• The Rams have lost four of their last five Week 10 games as favorites.
• The 49ers have covered the spread in each of their last eight games as underdogs against the Rams.
• The Rams have failed to cover the spread in five of their last six Week 10 games.
• The Rams have lost the first quarter in four of their last five November games as road favorites.
• The 49ers have won the first half in eight of their last nine games in November.
• The 49ers have scored the first touchdown in five of their last six home games against NFC opponents.

Why the Los Angeles Rams will win

• The Rams have won each of their last 16 Sunday games as favorites.
• The 49ers have lost each of their last six games as moderate underdogs (+3.5 to +7.0 points).
• The 49ers have failed to cover the spread in each of their last 11 home games following a win.
• The Rams have covered the spread in each of their last 10 Sunday games as favorites.
• The Rams have won the first quarter in four of their last five games following a win.
• The 49ers have lost the first half in seven of their last eight Sunday games as underdogs.
• The Rams have scored the first touchdown in five of their last six games as road favorites against NFC opponents.

Total Points Facts

• Seven of the Rams’ last eight Sunday games as favorites have gone UNDER the total points line.
• Each of the 49ers’ last five Week 10 games have gone UNDER the total points line.
• Four of the last five games between teams from the same division have gone OVER the total points line.

San Francisco 49ers Player Prop Facts

• Brian Robinson has recorded 24+ rushing and receiving yards in each of his 11 previous November appearances.
• Brian Robinson has recorded 22+ rushing yards in each of his 10 previous appearances with his team as a home underdog.
• Christian McCaffrey has recorded 52+ receiving yards in each of the 49ers’ last seven games against NFC opponents.
• Brian Robinson has scored the first touchdown in three of his last four November appearances with his team as an underdog.
• Christian McCaffrey has scored at least one touchdown in 11 of his last 12 home appearances against teams that held a winning record.
• Brock Purdy has recorded 277+ passing yards in each of his last four appearances.
• Russell Gage has scored the last touchdown in three of his last four regular season appearances with his team as an underdog.
• Brock Purdy has recorded 22+ completions in each of his last four appearances.
• Heading into Week 10, Christian McCaffrey is the only player in the NFL to record 500 rushing yards and 500 receiving yards this season.

Los Angeles Rams Player Prop Facts

• Kyren Williams has recorded 94+ rushing yards in each of the Rams’ last four road games against NFC opponents.
• Tyler Higbee has recorded 20+ receiving yards in 12 of his last 13 regular season road appearances against NFC West opponents.
• Kyren Williams has scored at least one touchdown in nine of his last 10 appearances with the Rams as favorites against NFC opponents.
• Matthew Stafford has recorded 298+ passing yards in each of the Rams’ last five games as favorites following a home win.
• Kyren Williams has scored two or more touchdowns in three of his four previous appearances against the 49ers.
• Kyren Williams has recorded 95+ rushing and receiving yards in each of the Rams’ last six road games against NFC opponents.
• Matthew Stafford has recorded 23+ completions in each of the Rams’ last six games as favorites following a home win.
• Heading into Week 10, Davante Adams ranks 1st in the NFL in receiving touchdowns (8) this season.

Matchup/League Facts

• Heading into Week 10, the 49ers have recorded the most wins by a margin of 10 points or less this season (6).
• Heading into Week 10, the 49ers have recorded the equal-most wins by a margin of five points or less this season (4).
• Heading into Week 10, the Rams rank 1st in the NFL in passing yards per game (258.0) this season.
• Heading into Week 10, the Rams rank 32nd in the NFL in kickoff return yards per game (69.5) this season.

Los Angeles Rams vs. San Francisco 49ers Prediction

I’m on the Rams here. The 49ers beat the Rams earlier this season so it’s obviously a revenge spot for LA, and the Rams have just been the much hotter team as of late. The 49ers have been inconsistent and injury riddled, and the Rams historically have had an edge in recent years with regards to the ATS head-to-head. I think the Rams get it done here and are laying points on the road in a division matchup for a reason. Give me the Rams.