Sep 7, 2025; Foxborough, Massachusetts, USA; Las Vegas Raiders running back Ashton Jeanty (2) rushes the ball against the New England Patriots during the second half at Gillette Stadium. Mandatory Credit: Bob DeChiara-Imagn Images

Los Angeles Chargers vs Las Vegas Raiders Prediction 9/15/2025 Today’s NFL Picks

Pick details

Los Angeles (1-0) vs Las Vegas (1-0)

September 15, 2025 at 10:00 PM EDT

The Line: Betting Odds: Las Vegas +3 — Over/Under: +46.5

(Get latest betting odds)

The Los Angeles Chargers and Las Vegas Raiders meet Monday in NFL action at Allegiant Stadium. Here’s a Los Angeles Chargers vs Las Vegas Raiders Prediction. This article will include a Los Angeles Chargers vs Las Vegas Raiders Pick.

Los Angeles Chargers Betting Preview


The Los Angeles Chargers beat the Chiefs, and they play the Broncos and Giants next. The Los Angeles Chargers have won 4 straight regular season games. Justin Herbert is completing 73.5 percent of his passes for 318 yards, 3 touchdowns, and 0 interceptions. Quentin Johnston and Ladd McConkey have combined for 153 receiving yards and 2 touchdowns, while Keenan Allen has 7 receptions.

The Los Angeles Chargers ground game is averaging 90 yards per contest, and Omarion Hampton leads the way with 48 yards on 15 carries. Defensively, Los Angeles is allowing 21 points and 347 yards per game. Alohi Gilman leads the Los Angeles Chargers with 9 tackles, Daiyan Henley has 1 sack and Teair Tart has 2 pass deflections.

Las Vegas Raiders Betting Preview


The Las Vegas Raiders beat the Patriots, and they play the Commanders and Bears next. The Las Vegas Raiders have won 3 of their last 4 games. Geno Smith is completing 70.6 percent of his passes for 362 yards, 1 touchdown, and 1 interception. Brock Bowers and Jakobi Meyers have combined for 200 receiving yards on 13 catches, while Tre Tucker has 2 receptions.

The Las Vegas Raiders ground game is averaging 56 yards per contest, and Ashton Jeanty leads the way with 38 yards and 1 touchdown. Defensively, Las Vegas is allowing 13 points and 336 yards per game. Devin White leads the Las Vegas Raiders with 11 tackles, Jonah Laulu has 1 sack and Isaiah Pola-Mao has 1 interception.

Los Angeles Chargers @ Las Vegas Raiders Betting Trends: Week 2


Why the Las Vegas Raiders will win

  • The Raiders have won four of their last five September games as home underdogs.
  • The Chargers have lost 10 of their last 11 Week 2 games against AFC West opponents.
  • The home team has covered the spread in seven of the last eight games between the Chargers and Raiders.
  • The Chargers have failed to cover the spread in six of their last seven Monday games played on the West Coast.
  • The Raiders have won the first half in three of their last four Monday games against teams that held a winning record.

Why the Los Angeles Chargers will win

  • The Chargers have won each of their last six September games against the Raiders.
  • The Raiders have lost eight of their last nine September home games against AFC West opponents.
  • The Chargers have covered the spread in eight of their last nine games as favorites against AFC opponents.
  • The Raiders have failed to cover the spread in five of their last six games at Allegiant Stadium against teams that held a winning record.
  • The Raiders have lost the first quarter in three of their last four home games.
  • The Raiders have lost the first half in eight of their last nine games as underdogs against AFC opponents.

Total Points Facts

  • Each of the Chargers’ last seven Monday games as favorites have gone UNDER the total points line.
  • Each of the Raiders’ last six September games against AFC West opponents have gone UNDER the total points line.
  • Three of the last four games between AFC West teams have gone OVER the total points line.

Las Vegas Raiders Player Prop Facts

  • Jakobi Meyers has scored a touchdown in five of his last six home appearances against teams with a winning record.
  • Geno Smith has recorded 289+ passing yards in six of his last seven September appearances.
  • Jakobi Meyers has recorded 59+ receiving yards in each of the Raiders’ last six games as underdogs.
  • Raheem Mostert has recorded 82+ rushing yards in three of his last four home appearances against AFC West opponents.
  • Jakobi Meyers has recorded 56+ rushing and receiving yards in each of the Raiders’ last six games following a win.
  • Geno Smith has recorded 24+ completions in each of his last four September appearances.
  • Heading into Week 2, Michael Mayer ranks T1st amongst qualified players for catch rate (100.0%) this season.

Los Angeles Chargers Player Prop Facts

  • Najee Harris has scored at least one touchdown in four of his five previous appearances on the West Coast.
  • Justin Herbert has recorded 314+ passing yards in each of his four previous road appearances against the Raiders.
  • Ladd McConkey has recorded 58+ receiving yards in each of his last eight regular season appearances.
  • Najee Harris has recorded 65+ rushing yards in five of his last six appearances against AFC West opponents.
  • Ladd McConkey has recorded 58+ rushing and receiving yards in each of his last eight regular season appearances.
  • Justin Herbert has recorded 22+ completions in each of his four previous road appearances against the Raiders.
  • Heading into Week 2, Quentin Johnston ranks T1st in the NFL in receiving touchdowns (2) this season.

Matchup/League Facts

  • Raiders – two different players have recorded 90+ receiving yards in a game this season – most in the NFL, heading into Week 2.
  • Raiders – one different players have recorded 100+ receiving yards in a game this season – equal-most in the NFL, heading into Week 2.
  • Chargers – three different players have recorded 60+ receiving yards in a game this season – equal-most in the NFL, heading into Week 2.
  • Chargers – two different players have recorded 70+ receiving yards in a game this season – equal-most in the NFL, heading into Week 2.

Los Angeles Chargers vs Las Vegas Raiders Prediction


You’re going to have chances to make money on the Raiders this season, as they’re going to be underdogs a lot, but there’s talent here. Geno pushes the ball down field, he has weapons, and the defense isn’t terrible. The Raiders can be better than many expect. However, the Chargers are simply the better team across the board, and they’ve had extra time to prepare for this game.

The team to win the last 10 games between the Chargers and Raiders is also 9-0-1 ATS. The Chargers are 11-3 ATS in their last 14 games as a favorite. This feels like a spot where the Raiders could have issues matching the Chargers score for score. I’ll take the Chargers by a touchdown.

Randy Chambers's Pick: Los Angeles Chargers -3

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