Los Angeles Chargers vs Kansas City Chiefs Prediction 12/14/2025 Today’s NFL Picks

The Los Angeles Chargers and the Kansas City Chiefs meet in week 15 NFL action from GEHA Field at Arrowhead Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Los Angeles Chargers vs. Kansas City Chiefs prediction.

Los Angeles Chargers Recap

The Los Angeles Chargers come into this game looking to add on to their 22-19 win over the Philadelphia Eagles last time out to sit at 9-4 this season. After this game, Los Angeles will head on the road for a game against the Dallas Cowboys.

Chargers Win 5 Of Last 6

Justin Herbert has thrown for 2,981 yards, 22 touchdowns and 11 interceptions on 65.6% passing while Kimani Vidal also has 587 rushing yards and 3 TDs as well this season. Omarion Hampton has 370 rushing yards and Ladd McConkey leads the Chargers with 695 receiving yards coming on 59 catches with 5 TDs while Keenan Allen has a team-high 63 catches for 644 yards and 4 TDs. Quentin Johnston has 533 receiving yards with 7 TDs and Oronde Gadsden II has 39 catches for 541 yards as well. On defense, Daiyan Henley has a team-high 82 total tackles including 47 solo tackles. Tuli Tuipulotu has a team-high 10 sacks while the Chargers’ defensive unit as a whole has combined for 35 sacks and 15 interceptions so far this season. 

Kansas City Chiefs Recap

The Kansas City Chiefs come into this game looking to rebound from their 20-10 loss at the hands of Houston in their last game to sit at 6-7 this season. After this game, Kansas City will head on the road for a game against the Tennessee Titans.

Chiefs Drop 4 Of Last 5

Patrick Mahomes has thrown for 3,398 yards, 22 touchdowns and 10 interceptions on 63.1% passing while also rushing for 407 yards and 4 TDs. Kareem Hunt has rushed for a team-high 545 yards and 8 TDs while Isiah Pacheco has rushed for 375 yards. Travis Kelce leads the Chiefs with 60 catches for 727 yards and 5 TDs while Rashee Rice has 520 receiving yards with 5 TDs and Hollywood Brown has 494 receiving yards with 5 TDs as well. Xavier Worthy has 456 receiving yards and Tyquan Thornton has 391 receiving yards while JuJu Smith-Schuster has 304 receiving yards as well this season. On defense, Nick Bolton leads the Chiefs with 112 total tackles while George Karlaftis has a team-high 6 sacks. As a unit, Kansas City’s defense has combined for 25 sacks and 7 interceptions so far this season.

Los Angeles Chargers @ Kansas City Chiefs Betting Trends: Week 15

Why the Kansas City Chiefs will win

• The Chiefs have won each of their last 13 games following a home loss.
• The Chargers have lost each of their last eight games as road underdogs against AFC opponents.
• The home team has covered the spread in each of the Chargers’ last six games.
• The Chargers have failed to cover the spread in each of their last four road games.
• The Chiefs have scored the first touchdown in 11 of their last 12 Week 15 games.
• The Chiefs have won the first quarter in each of their last six Week 15 home games.
• The Chiefs have won the first half in each of their last 11 Week 15 home games.

Why the Los Angeles Chargers will win

• The Chargers have won each of their last six games against AFC West opponents.
• The Chiefs have lost five of their last six games as favorites against opponents on a winning streak.
• The Chiefs have failed to cover the spread in each of their last nine games without Isiah Pacheco.
• The Chargers have covered the spread in each of their last eight games against AFC West opponents.
• The Chargers have scored the first touchdown in each of their last five games as underdogs following a home win.
• The Chiefs have lost the first quarter in each of their last four games as favorites against AFC opponents.
• The Chiefs have lost the first half in each of their last three games as moderate favorites (-3.5 to -7.0 points).

Total Points Facts

• Each of the last nine games between teams from the same division have gone OVER the total points line.
• Each of the Chiefs’ last nine games at GEHA Field at Arrowhead Stadium following a loss have gone UNDER the total points line.
• Each of the Chargers’ last six Sunday games as underdogs have gone UNDER the total points line.

Kansas City Chiefs Player Prop Facts

• Kareem Hunt has scored a touchdown in each of the Chiefs’ last four games against teams that held a winning record.
• Patrick Mahomes has recorded 24+ completions in each of the Chiefs’ last 10 home games against AFC West opponents.
• Travis Kelce has recorded 44+ receiving yards in each of his last 13 appearances against AFC West opponents.
• Patrick Mahomes has recorded 250+ passing yards in nine of the Chiefs’ last 10 games.
• Patrick Mahomes has recorded 28+ rushing yards in each of the Chiefs’ last six games as home favorites.
• Marquise Brown has recorded 25+ rushing and receiving yards in each of his last eight December appearances with his team as a favorite.
• Heading into Week 15, Patrick Mahomes ranks 3rd in the NFL in passing yards (3398) this season.

Los Angeles Chargers Player Prop Facts

• Keenan Allen has scored at least one touchdown in five of his last six appearances with the Chargers as underdogs following a win.
• Justin Herbert has recorded 21+ completions in each of his eight previous December road appearances against AFC opponents.
• Kimani Vidal has recorded 30+ rushing yards in five of the Chargers’ last six games.
• Justin Herbert has recorded 213+ passing yards in each of his 14 previous road appearances against AFC West opponents.
• Keenan Allen has recorded 34+ receiving yards in each of his last 38 Sunday appearances with the Chargers as underdogs.
• Ladd McConkey has recorded 48+ rushing and receiving yards in seven of his last eight road appearances against AFC opponents.
• Heading into Week 15, Cameron Dicker ranks T1st in the NFL in made field goals (31) this season.

Matchup/League Facts

• Heading into Week 15, the Chiefs rank 1st in the NFL in 4th down percentage against (27.8%) this season.
• Heading into Week 15, the Chiefs have suffered the equal-most losses by a margin of 10 points or less this season (7).
• Chargers – two different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 15.
• Chargers – two different players have recorded 90+ rushing yards in a game this season – equal-most in the NFL, heading into Week 15.

Los Angeles Chargers vs. Kansas City Chiefs Prediction

I’m on the Chargers and the points here. Historically this has been a close matchup, and while the Chiefs are in must-win mode to keep their playoff hopes alive now that the division is out of the question, this is a team that continues to have issues in close games. Los Angeles is still in the mix for the division title, and a win here could not only go a long way towards securing their playoff bid, but knocking off a rival’s and I think that this one could come down to the wire as well. Give me Los Angeles and the points.

Chris Ruffolo's Pick: Los Angeles Chargers +5.5