Jacksonville Jaguars vs Denver Broncos Prediction 12/21/2025 Today’s NFL Picks

The Jacksonville Jaguars and the Denver Broncos meet Sunday in NFL action from Empower Field at Mile High in Denver. Here’s a Jaguars vs Broncos prediction. We will look at this from a betting perspective and determine the best Jaguars vs Broncos pick. We will examine the recent form and player performances for both teams, as well as the recent betting trends and streaks pertaining to this matchup. As we conclude, we will tie it all together with a summary that produces a sensible pick for a favorable betting outcome in this game.

Jacksonville Jaguars Betting Preview

The Jags went into their bye week with a 4-3 record, taking losses to the Bengals, Seahawks and Rams. The wins otherwise were over the Panthers, Texans, 49ers and Chiefs. Jacksonville lost to only Houston in their next six games, beating the Raiders, Chargers, Cardinals, Titans and Colts otherwise. That would give the Jaguars a 9-4 overall record through their first 13 games this year.

In the Jets game on Sunday the Jags were up 31-10 by the break. Jacksonville ended up scoring in every quarter during a 48-20 win. QB Trevor Lawrence finished 20-of-32 for 330 yards and five scores. Lawrence also led the rush with 51 yards and a score on five carries, and Travis Etienne had three catches for 73 yards and three touchdowns in the victory effort.

Denver Broncos Betting Preview

Over on the Broncos’ side, they beat the Titans in their opener then fell to the Colts and Chargers. Denver went into their bye with a long winning streak over the Bengals, Eagles, Jets, Giants, cowboys, Texans, Raiders and Chiefs, then took out the Commanders and Raiders in the next pair. Over their first 13 games of the year the Broncos managed a nice 11-2 overall record.

In the Packers game on Sunday the Broncos were down 16-14 going into the second half. Denver scored another 20 points from there and took the comeback win 34-26 in the end. QB Bo Nix had a 23-of-34 line for 302 yards and four scores while RJ Harvey paced the rush on 19 carries for 65 yards and a TD of his own. Tops in receiving was Courtland Sutton with seven grabs for 113 yards and a score.

Jacksonville Jaguars @ Denver Broncos Betting Trends: Week 16

Why the Denver Broncos will win

• The Broncos have won each of their last 12 games at Empower Field at Mile High.
• The Jaguars have lost each of their last six road games against AFC West opponents on a winning streak.
• The Broncos have covered the spread in each of their last six home games without Alex Singleton.
• The Jaguars have failed to cover the spread in seven of their last eight games as underdogs without Travis Etienne.
• The Jaguars have lost the first quarter in nine of their last 11 road games in December.
• The favorites have won the first half in each of the last five games between the Jaguars and Broncos.

Why the Jacksonville Jaguars will win

• The Broncos have lost four of their last five Week 16 games as favorites.
• The Jaguars have won each of their last three games as underdogs against opponents on a winning streak.
• The Broncos have failed to cover the spread in 10 of their last 11 Week 16 games.
• The underdogs have covered the spread in nine of the Broncos’ last 10 games.
• The Broncos have lost the first quarter in each of their last two December games as favorites against AFC South opponents.
• The Broncos have lost the first half in three of their last four Sunday games against teams that held a winning record.

Total Points Facts

• Each of the Broncos’ last six games as favorites following a home win have gone OVER the total points line.
• Each of the Jaguars’ last five games as road underdogs following a win have gone OVER the total points line.

Denver Broncos Player Prop Facts

• Bo Nix has recorded 24+ completions in each of the Broncos’ last three December games against AFC opponents.
• Bo Nix has recorded 247+ passing yards in each of the Broncos’ last four Sunday games at Empower Field at Mile High.
• RJ Harvey has scored at least one touchdown in each of the Broncos’ last four Sunday games as favorites.
• Jaleel McLaughlin has recorded 15+ rushing yards in each of his eight previous December appearances against AFC opponents.
• Jaleel McLaughlin has recorded 34+ rushing and receiving yards in each of the Broncos’ last four December home games against AFC opponents.
• Courtland Sutton has recorded 59+ receiving yards in each of the Broncos’ last six Sunday games at Empower Field at Mile High.
• Heading into Week 16, Bo Nix ranks 1st in the AFC amongst qualified players for sack percentage (3.1%) this season.

Jacksonville Jaguars Player Prop Facts

• Trevor Lawrence has recorded 23+ completions in each of his four previous road appearances against AFC West opponents.
• Trevor Lawrence has recorded 229+ passing yards in each of the Jaguars’ last four games.
• Travis Etienne has scored at least one touchdown in five of the Jaguars’ last six Sunday games.
• Jakobi Meyers has recorded 64+ rushing and receiving yards in seven of his last eight appearances with his team as an underdog against AFC West opponents.
• Jakobi Meyers has recorded 52+ receiving yards in each of his last nine appearances against AFC West opponents.
• Trevor Lawrence has recorded 16+ rushing yards in seven of the Jaguars’ last eight Sunday games.
• Heading into Week 16, Travis Etienne has recorded the equal-most receiving touchdowns in a single game this season (3 vs Jets, Week 15).

Matchup/League Facts

• Heading into Week 16, the Broncos rank 1st in the NFL in 3rd down percentage against (31.9%) this season.
• Heading into Week 16, the Broncos have recorded the equal-most wins when trailing after Q3 this season (5).
• Heading into Week 16, the Jaguars rank 1st in the NFL in rushing yards allowed per game (86.3) this season.
• Heading into Week 16, the Jaguars have played in the equal-highest number of games that went to overtime this season (2).

Jaguars vs Broncos Prediction

I’ll stick with the Broncos, but this should be a fun matchup regardless. Denver continued their miraculous campaign with a victory versus a good Packers team last weekend, amassing 391 yards, 302 pass yards and 21 first downs along the way. The Broncos weren’t great on third downs (4-of-11) but Green Bay’s 10 penalties didn’t hurt matters either. Denver has 11 straight wins now, with all but a couple of them coming by one score. It’s been quite the heart-attack season, but in a good way.

As for the Jags, they demolished the lowly Jets last weekend to the tune of 438 yards, 7.4 yards per play and 24 first downs. The defense gave up 284 yards on the other side with 154 pass yards, 19 first downs and three picks. Jacksonville is scoring great lately with 25 or more points in seven straight games since their bye week. This one could very well end up a pretty high total if both teams play well.

Andrew Jett's Pick: Denver Broncos -3