Houston Texans vs Los Angeles Rams Prediction 9/7/2025 Today’s NFL Picks

The Houston Texans and the Los Angeles Rams meet in week 1 NFL action from SoFi Stadium on Sunday. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Houston Texans vs. Los Angeles Rams prediction.

Houston Texans Team Preview

The Houston Texans enter 2025 after finishing 10–7 in 2024, winning the AFC South and a wild-card playoff game before falling in the divisional round. The offseason brought significant roster turnover. The team traded Pro Bowl left tackle Laremy Tunsil to Washington, acquiring multiple draft picks, and addressed the offensive line by signing veteran Cam Robinson and other linemen while moving on from Kenyon Green. The secondary was boosted with safety C.J. Gardner-Johnson arriving via trade. Running back Nick Chubb was added on a one-year deal to deepen the backfield. In the draft, without a first-round selection, Houston used its top pick at No. 34 overall on wide receiver Jayden Higgins from Iowa State. Leadership also saw changes: offensive coordinator Bobby Slowik was fired after the 2024 season and replaced by former Rams assistant Nick Caley. With a restructured offensive line, added weapons, and new play-caller, the Texans look to defend their division title and take the next step in 2025.

Why the Houston Texans will win

• The road team has won four of the five previous games between the Texans and Rams.
• The Rams have lost three of their last four September games against AFC opponents.
• The Texans have covered the spread in each of their last six Sunday games as road underdogs.
• The Rams have failed to cover the spread in each of their last four September games against AFC opponents.

Houston Texans Player Prop Facts

• C.J. Stroud has recorded 22+ completions in three of the Texans’ last four regular season road games.
• Joe Mixon has scored at least one touchdown in six of his last seven Sunday road appearances.
• Joe Mixon has recorded 87+ rushing and receiving yards in seven of his last eight Sunday road appearances.
• Joe Mixon has recorded 18+ receiving yards in five of the Texans’ last six Sunday games.
• Joe Mixon has recorded 65+ rushing yards in eight of his last nine Sunday road appearances.
• Joe Mixon recorded the equal-most rushing touchdowns in a single game last season (3 vs Cowboys, Week 11).

Los Angeles Rams Team Preview

The Los Angeles Rams enter 2025 after a 10–7 season that secured an NFC West title and included a Wild Card win over Minnesota before falling to Philadelphia in the divisional round. The offseason brought sweeping changes, highlighted by the release of longtime star Cooper Kupp, who signed with Seattle, and the arrival of All-Pro wideout Davante Adams on a two-year deal to replace him. The Rams also reinforced the offensive line by adding veteran tackle D.J. Humphries and re-signing center Coleman Shelton, while former Cardinals starter Cam Robinson was brought in after Jonah Jackson was traded to Chicago. On defense, Los Angeles added tackle Poona Ford but lost contributors including Joe Noteboom, Michael Hoecht, Bobby Brown III, and Demarcus Robinson. In the draft, the Rams did not have a first-round pick, making Oregon tight end Terrance Ferguson their top choice in the second round, followed by Michigan edge rusher Josaiah Stewart in the third. On the sidelines, Sean McVay remains head coach, with Mike LaFleur continuing as offensive coordinator, while Chris Shula steps in as defensive coordinator following Raheem Morris’s departure to Atlanta. Only time will tell if the Rams can stay the course in the once again competitive NFC West.

Why the Los Angeles Rams will win

• The Texans have lost each of their last 19 games as road underdogs against NFC opponents.
• The Rams have won each of their last 10 Sunday games as favorites.
• The Rams have covered the spread in seven of their last eight games.
• The Texans have failed to cover the spread in seven of their last eight games in September.

Los Angeles Rams Player Prop Facts

• Kyren Williams has scored the last touchdown in three of his last four Sunday appearances with the Rams as home favorites.
• Kyren Williams has scored the first touchdown in each of his last four home appearances.
• Davante Adams has recorded 72+ receiving yards in each of his last seven appearances against AFC South opponents.
• Kyren Williams has recorded 76+ rushing yards in 10 of his last 11 Sunday appearances with the Rams as favorites.
• Matthew Stafford has recorded 240+ passing yards in each of his 14 previous September appearances against AFC opponents.
• Matthew Stafford has recorded 24+ completions in eight of his last nine Week 1 appearances.
• Kyren Williams has scored at least one touchdown in each of his last eight Sunday home appearances.
• Puka Nacua has recorded 98+ rushing and receiving yards in each of his last six regular season home appearances.
• Kamren Kinchens recorded the equal-most interceptions in a single game last season (2 vs Seahawks, Week 9).

Total Points Facts

• Each of the last six Sunday games at SoFi Stadium have gone OVER the total points line.
• Each of the Rams’ last four games played as favorites on the West Coast have gone UNDER the total points line.
• Four of the Texans’ last five road games against NFC opponents have gone UNDER the total points line.

Houston Texans vs. Los Angeles Rams Prediction

I’m initially leaning towards the Texans here as I’m just not 100% sold on Matthew Stafford being completely healthy for this game as Sean McVay has continued to say it’s day-to-day monitoring which isn’t good considering that the Texans have a nasty pass rush and a strong defense overall that can make life hell for any QB on their best day. I think the Texans are live to start with a win here so give me Houston here.