Green Bay Packers vs Indianapolis Colts Prediction 8/16/2025 Today’s NFL Picks

In this article, we will formulate a Packers vs Colts Prediction for this NFL Week 2 Preseason game on Saturday, August 16th at the Lucas Oil Stadium. Let’s take a look at the prediction for this NFL matchup.

Indianapolis Colts Preview

The Colts are coming off a 16-24 road defeat by the Ravens in their preseason opener last week. They outgained their opponents by 366-226 yards and had 78 total plays. They had 24/48 completed passes, 240 passing yards, 126 rushing yards, winning the turnover battle by 1-2. The Colts went 6-19 in third down efficiency and were 1-3 in the red zone. The Colts struggled in the opening period of the game, where they fell behind by 6-14, and never managed to bounce back.

Daniel Jones had 10/21 passes with a team-high 144 passing yards, Riley Leonard had 12/24 passes with 92 yards, while Anthony Richardson Sr. had 2/3 passes for 21 yards. Ulysses Bentley IV had a team-high 35 rushing yards, while Ashton Dulin caught 3 passes for 54 yards. Defensively, Hunter Wohler had 9 total tackles, 6 of them solo, while Adetomiwa Adebawore and JT Tuimoloau had one sack apiece. Joe Bachie and Alex Johnson had one interception each.

Indianapolis was 2-1 in the 2024 preseason, losing the opener at home by Denver with a 30-34 score, then followed with a 21-13 home victory over Arizona and a 27-14 road victory over Cincinnati.

Green Bay Packers Preview

The Packers are coming off a 10-30 home defeat by the Jets in the preseason opener last week. They got badly outgained by their opponents by 188-403 yards and had 47 total plays. They had 10/22 completed passes, 64 passing yards, 124 rushing yards, and lost the turnover battle by 0-2. The Packers went 1-10 in third down efficiency and were 0-0 in the red zone. They got outscored in each of the first three periods of the game by 0-7, 3-10 and 0-7, but managed to outscore the Jets 7-6 in the final period only to cut the deficit to 20.

Malik Willis led the team with 4/9 passes and a team-high 39 passing yards, Taylor Elgersma had 3/4 passes for 24 yards and Sean Clifford had 2/4 passes for 14 yards. Amar Johnson had a team-high 67 rushing yards, while Will Sheppard caught 2 passes for 20 yards. Defensively, Kristian Welch had 9 total tackles, 4 of them solo, and the Packers did not have any interceptions in that game.

Green Bay was 2-1 in the 2024 preseason, winning in the opener on the road against Cleveland by 23-10, followed by a 2-27 road defeat in Denver and a 30-7 home victory over Baltimore.

Packers vs Colts Prediction

In their previous meeting last season, the Packers won 16-10 at home, covering the spread as the game went under the 41-point total. The Colts have won the previous three meetings before that, and have won both of their two meetings in Indianapolis by 34-31 and 30-27. Over is 4-1 in their five meetings.

In this Packers vs Colts Prediction, the Colts are coming as -6-point home favorites. Both teams are coming off defeats in their preseason openers, and both offenses looked terrible, having scored just 26 points combined. Both teams looked really bad, especially the Packers, but I’m still not convinced that the Colts can cover the spread in this one. In their previous meeting last season they combined for just 26 total, points, and I like another low-scoring grind today. Take the under 40 points in this one.