Green Bay Packers vs Cleveland Browns Prediction 9/21/2025 Today’s NFL Picks

In this article, we will formulate a Packers vs Browns Prediction for this NFL Week 3 game on Sunday, September 21st at the Huntington Bank Field. Let’s take a look at the prediction for this NFL matchup.

Cleveland Browns Preview

Cleveland has a 0-2 record this season and are coming off a 17-41 loss in Baltimore. Offensively, the Browns average 16.5 points per game, which ranks 27th in the NFL. Defensively, they allow 29 points per game, which ranks 25th in the league. Cleveland averages 324.5 total yards per game, with 82.0 rushing yards and 242.5 passing yards per game. They allow 191.5 total yards per game, 45.5 rushing and 146 passing yards per game.

Joe Flacco leads the Browns with 56/90 completed passes and 489 total passing yards. He also adds 14 rushing yards. Quinshon Judkins leads the team in rushing yards, with 61, while Jerome Ford adds 39 rushing yards. Harold Fannin has a team-high 12 caught passes for 111 receiving yards. Dylan Sampson has caught 11 passes for 77 yards, and one touchdown.

Defensively, Devin Bush Jr. has a team-high 15 total tackles, 8 of them solo, and one sack. Carson Schwesinger adds 13 total tackles, 5 of them solo. Myles Garrett leads the Browns in sacks, with 3.5.

Green Bay Packers Preview

Green Bay has a 2-0 record this season and is coming off a 27-18 home victory over Washington. Offensively, the Packers average 27 points per game, which ranks 6th in the league. Defensively, they allow 15.5 points per game, which ranks 4th in the league. Green Bay averages 335 total yards per game, with 106.5 rushing yards and 228.5 passing yards per game. They allow 238 total yards per game, 48.5 rushing and 189.5 passing yards per game.

Jordan Love leads the Packers with 35/53 completed passes and 480 total passing yards. He also adds 16 rushing yards. Josh Jacobs leads the team in rushing yards, with 150 and 2 touchdowns, while Savion Williams adds 24 rushing yards. Tucker Kraft has a team-high 8 caught passes for a team-high 140 receiving yards, and has 2 touchdowns. Dontayvion Wicks has caught 6 passes for 74 yards.

Defensively, Edgerrin Cooper has a team-high 22 total tackles, 15 of them solo, and 0.5 sacks. Evan Williams adds 8 total tackles, 3 of them solo and one interception. Rashan Gary leads the Packers in sacks, with 2.5, while Evan Williams has a team-high one interception.

Green Bay Packers @ Cleveland Browns Betting Trends: Week 3

Why the Cleveland Browns will win

• The underdogs have won each of the Packers’ last five Week 3 games.
• The Packers have lost each of their last three Week 3 games as road favorites.
• The Packers have failed to cover the spread in seven of their last eight games as favorites against AFC opponents.
• The underdogs have covered the spread in seven of the Packers’ last eight Week 3 games.
• The Packers have lost the first quarter in three of their last four games as favorites against AFC North opponents.
• The Browns have scored the first touchdown in each of their last four Week 3 games.
• The home team has won the first half in five of the Packers’ last six games.

Why the Green Bay Packers will win

• The Browns have lost each of their last eight games.
• The Packers have won each of their last eight September games against AFC opponents.
• The Packers have covered the spread in each of their last six Week 3 games.
• The Browns have failed to cover the spread in seven of their last eight games.
• The Browns have lost the first quarter in each of their last six games.
• The Packers have scored the first touchdown in each of their last seven games as road favorites.
• The Browns have lost the first half in each of their last 10 Sunday games.

Total Points Facts

• Each of the Packers’ last eight road games following a home win have gone OVER the total points line.
• Each of the Browns’ last six games against NFC North opponents have gone UNDER the total points line.
• Each of the last four Sunday games at Huntington Bank Field have gone UNDER the total points line.

Cleveland Browns Player Prop Facts

• Cedric Tillman has scored at least one touchdown in each of his last four Sunday appearances with the Browns as underdogs.
• Joe Flacco has recorded 262+ passing yards in each of his last 10 home appearances as a starter.
• Deshaun Watson has recorded 26+ rushing yards in four of his five previous September appearances against NFC opponents.
• Jerome Ford has recorded 69+ rushing and receiving yards in four of the Browns’ last five home games against NFC opponents.
• Cedric Tillman has scored the last touchdown in each of his last three Sunday home appearances.
• Jerry Jeudy has recorded 66+ receiving yards in each of the Browns’ last six home games.
• Joe Flacco has recorded 25+ completions in each of his last seven Sunday appearances at Huntington Bank Field.
• Heading into Week 3, Myles Garrett ranks T1st in the NFL in sacks (3.5) this season.

Green Bay Packers Player Prop Facts

• Josh Jacobs has scored the first touchdown in three of the Packers’ last four games as road favorites.
• Josh Jacobs has scored at least one touchdown in each of the Packers’ last 11 games.
• Josh Jacobs has recorded 92+ rushing and receiving yards in seven of his last eight appearances with his team as a favorite against AFC opponents.
• Dontayvion Wicks has recorded 30+ receiving yards in each of the Packers’ last five games.
• Jordan Love has recorded 246+ passing yards in five of his last six September appearances.
• Jordan Love has recorded 11+ rushing yards in four of his five previous road appearances against AFC opponents.
• Jordan Love has recorded 21+ completions in six of his last seven appearances against AFC opponents.
• Heading into Week 3, Daniel Whelan ranks 1st amongst qualified players for gross average yards per punt (53.9) this season.

Matchup/League Facts

• Browns – three different players have recorded 60+ receiving yards in a game this season – equal-most in the NFL, heading into Week 3.
• Heading into Week 3, the Browns rank 1st in the NFL in yards allowed per game (191.5) this season.
• Packers – one different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into Week 3.
• Heading into Week 3, the Packers rank 1st in the NFL in average yards per punt (53.9) this season.

Packers vs Browns Prediction

In their most recent meeting back in 2021, Green Bay won 24-22 at home, not covering the spread. The Packers have won all four meetings against the Browns, including both trips to Cleveland. The Packers are 3-1 against the spread in their four meetings, and under is 2-1-1.

In this Packers vs Browns Prediction, the Packers are coming as -7.5-point road favorites, with the total set at 41.5 points. Both teams are coming off completely opposite starts to the season, with Green Bay being undefeated, winning by an average of 7.5 points per game, having covered the spread in both. They are ranked in the top-6 of the league both offensively and defensively, while Cleveland is winless and ranks on the bottom-8 of the league both offensively and defensively, losing by an average of 12.5 points per game. Green Bay has historically dominated Cleveland, and I expect them to continue doing so today. Take the Green Bay Packers and lay the -7.5 points on the road.