Detroit Lions vs Green Bay Packers Prediction 9/7/2025 Today’s NFL Picks

In this article, we will formulate a Lions vs Packers Prediction for this NFL Week 1 game on Sunday, September 7th at the Lambeau Field. Let’s take a look at the prediction for this NFL matchup.

Green Bay Packers Preview

Green Bay finished the preseason with a 2-1 record. They lost at home by the Jets, 10-30, won Indianapolis on the road by 23-19 and Seattle at home by 20-7.  

Offensively, Green Bay finished the preseason averaging 17.7 points per game, while allowing 18.7 points per game defensively. The Packers averaged 123.3 rushing yards and 139.7 passing yards per game. They allowed 123.3 rushing yards per game and 215.3 passing yards per game.

Malik Willis led the Packers in the preseason with 13/29 completed passes and 172 total passing yards. He also had 1 touchdown and 1 interception. Taylor Elgersma had 16/23 passes for 166 passing yards and 1 touchdown, while Sean Clifford added 9/17 passes for 44 passing yards. Amar Johnson led the team in rushing yards, with 115 and 2 touchdowns, while Emanuel Wilson had 71 rushing yards. Chris Brooks had a team-high 6 caught passes for 63 receiving yards, while Malik Heath caught 4 passes for 42 yards.

Defensively, Ty’Ron Hopper had a team-high 15 total tackles, 8 of them solo, while Karl Brooks had a team-high 2.0 total sacks, and Carrington Valentine had a team-high 1 interception.

Detroit Lions Preview

Detroit finished the preseason with a 1-2 record. They won Atlanta on the road by 17-10, then lost at home by Miami 17-24, and by Houston, 7-26.   

Offensively, Detroit finished the preseason averaging 12.0 points per game, while allowing 23.5 points per game defensively. The Lions averaged 92.2 rushing yards and 133.5 passing yards per game. They allowed 97.5 rushing yards per game and 208.2 passing yards per game.

Kyle Allen led the Lions in the preseason with 42/68 completed passes and 401 total passing yards. He also had 2 touchdowns and 1 interception. Hendon Hooker had 30/48 passes for 298 passing yards and 2 touchdowns, while Adrian Martinez added 13/22 passes for 112 passing yards and 1 touchdown. Jacob Saylors led the team in rushing yards, with 112 and 1 touchdown, while Jackson Meeks had a team-high 12 caught passes for 176 receiving yards, and had 1 touchdown. Antoine Green caught 11 passes for 127 yards, and 1 touchdown.

Defensively, Anthony Pittman had a team-high 17 total tackles, 13 of them solo, while Al-Quadin Muhammad had a team-high 2.0 total sacks, and Tyson Russell had a team-high 1 interception.

Why the Green Bay Packers will win

• The Packers have won each of their last 12 home openers.
• The Lions have lost each of their last six road openers against NFC North opponents.
• The Packers have covered the spread in each of their last six home openers.
• The Lions have failed to cover the spread in five of their last six September games as underdogs against NFC North opponents.
• The home team has won the first quarter in 11 of the Lions’ last 13 games.
• The favorites have won the first half in each of the Lions’ last six Week 1 games.
• The Packers have scored the first touchdown in nine of their last 10 games as favorites.

Why the Detroit Lions will win

• The Lions have won each of their last eight road games.
• The Packers have lost four of their last five games as home favorites against NFC North opponents.
• The Lions have covered the spread in each of their last nine games as underdogs against NFC North opponents.
• The Packers have failed to cover the spread in each of their last six games against NFC North opponents.
• The Lions have won the first quarter in seven of their last eight road openers as underdogs.
• The Lions have won the first half in each of their last nine games against NFC North opponents.
• The Lions have scored the first touchdown in each of their last eight road games against the Packers.

Total Points Facts

• Each of the Lions’ last six September games against NFC North opponents have gone OVER the total points line.
• Each of the last four September games between the Lions and Packers have gone OVER the total points line.
• Three of the last four games between NFC North teams have gone OVER the total points line.

Matchup/League Facts

• Packers – six different players recorded 70+ receiving yards in a game last season – equal-most in the NFL.
• The Packers ranked 32nd in the NFL in punt return yards per game (9.3) last season.
• Lions – two different players recorded 100+ rushing yards in a game last season – equal-most in the NFL.
• The Lions ranked 1st in the NFL in points per game (33.2) last season.

Lions vs Packers Prediction

The Lions won both meetings against the Packers last season. At home by 34-31 and on the road by 24-14. They are dominating the Packers, as they are 6-1 in their last 7 head-to-head meetings, having won their last three visits in Green Bay. They are 5-2 against the spread in their last 7 meetings, and over is 3-1 in their last 4 meetings.

In this Lions vs Packers Prediction, the Packers are coming as -2.5-point home favorites. Green Bay significantly improved their roster in the offseason and they finally have some real experience on offense with Jordan Love and his young receivers growing together and building chemistry, but the secondary looks shaky. Detroit may take a few weeks to find their footing with new offensive and defensive coordinators and did not look good in the preseason. I don’t expect the Lions to suddenly turn the switch and open the season with a road win. Even though history says otherwise, I like the Green Bay Packers to win and cover in this season opener.