Denver Broncos vs Los Angeles Chargers Prediction 9/21/2025 Today’s NFL Picks

The Denver Broncos and Los Angeles Chargers meet Sunday in NFL action at SoFi Stadium. Here’s a Denver Broncos vs Los Angeles Chargers Prediction. This article will include a Denver Broncos vs Los Angeles Chargers Pick.

Denver Broncos Betting Preview

The Denver Broncos beat the Titans, lost to the Colts, and they play the Bengals next. The Denver Broncos have won 6 of their last 9 games. Bo Nix is completing 67.1 percent of his passes for 382 yards, 4 touchdowns, and 3 interceptions. Troy Franklin and Courtland Sutton have combined for 200 receiving yards and 2 touchdowns, while Marvin Mims Jr. has 5 receptions.

The Denver Broncos ground game is averaging 134.5 yards per contest, and J.K. Dobbins leads the way with 139 yards and 2 touchdowns. Defensively, Denver is allowing 20.5 points and 303 yards per game. Talanoa Hufanga leads the Denver Broncos with 21 tackles, Justin Strnad has 2 sacks and Riley Moss has 3 pass deflections.

Los Angeles Chargers Betting Preview

The Los Angeles Chargers beat the Chiefs and Raiders, and they play the Giants next. The Los Angeles Chargers have won 5 straight regular season games. Justin Herbert is completing 72.1 percent of his passes for 560 yards, 5 touchdowns, and 0 interceptions. Quentin Johnston and Keenan Allen have combined for 279 receiving yards and 5 touchdowns, while Ladd McConkey has 11 receptions.

The Los Angeles Chargers ground game is averaging 85.5 yards per contest, and Omarion Hampton leads the way with 72 yards on 23 carries. Defensively, Los Angeles is allowing 15 points and 282.5 yards per game. Daiyan Henley leads the Los Angeles Chargers with 18 tackles, Khalil Mack has 1 sack and Donte Jackson has 1 interception.

Denver Broncos @ Los Angeles Chargers Betting Trends: Week 3

Why the Los Angeles Chargers will win

• The home team has won 12 of the Broncos’ last 13 games.
• The Broncos have lost 12 of their last 13 road games against AFC opponents on a winning streak.
• The Chargers have covered the spread in nine of their last 10 games as favorites against AFC opponents.
• The Broncos have failed to cover the spread in each of their last four road games against AFC opponents.
• The Broncos have lost the first half in each of their last four September games as road underdogs against AFC opponents.

Why the Denver Broncos will win

• The Chargers have lost each of their last four Week 3 games as home favorites.
• The underdogs have won five of the Chargers’ last six Week 3 games.
• The road team has covered the spread in five of the Chargers’ last six Week 3 games.
• The Chargers have failed to cover the spread in nine of their last 11 September games as home favorites.
• The Chargers have lost the first quarter in three of their last four games as home favorites against AFC West opponents.
• The Chargers have lost the first half in five of their last six games as home favorites against AFC West opponents.

Total Points Facts

• Seven of the Chargers’ last eight games as favorites have gone OVER the total points line.
• Each of the Broncos’ last four games played on the West Coast have gone OVER the total points line.

Los Angeles Chargers Player Prop Facts

• Justin Herbert has recorded 281+ passing yards in four of the Chargers’ last five regular season games against AFC opponents.
• Keenan Allen has recorded 58+ receiving yards in 12 of his last 13 appearances with the Chargers as favorites.
• Najee Harris has recorded 48+ rushing and receiving yards in each of his 19 previous appearances with his team as a favorite following a win.
• Quentin Johnston has scored a touchdown in four of the Chargers’ last five Sunday games as favorites.
• Najee Harris has recorded 19+ rushing yards in each of his 19 previous appearances with his team as a favorite following a win.
• Justin Herbert has recorded 23+ completions in four of the Chargers’ last five regular season games.
• Heading into Week 3, Quentin Johnston ranks T1st in the NFL in receiving touchdowns (3) this season.

Denver Broncos Player Prop Facts

• J.K. Dobbins has scored a touchdown in six of his last seven appearances following a loss.
• J.K. Dobbins has recorded 53+ rushing yards in each of his seven previous road appearances against division opponents.
• J.K. Dobbins has scored the last touchdown in three of his last four Sunday appearances.
• Evan Engram has recorded 33+ receiving yards in five of his last six Sunday appearances with his team as an underdog.
• J.K. Dobbins has recorded 59+ rushing and receiving yards in each of his last six regular season appearances.
• Bo Nix has recorded 22+ completions in each of the Broncos’ last five regular season road games.
• Heading into Week 3, Brandon Jones ranks T1st in the league for fumbles recovered (1) this season.

Matchup/League Facts

• Heading into Week 3, the Chargers rank T1st in the NFL in Q1 win percentage (100.0) this season.
• Heading into Week 3, the Chargers rank T1st in the NFL in Q3 win percentage (100.0) this season.
• Broncos – two different players have recorded 70+ rushing yards in a game this season – equal-most in the NFL, heading into Week 3.
• Broncos – six different players have recorded 1.0 sacks or more in a game this season – equal-most in the NFL, heading into Week 3.

Denver Broncos vs Los Angeles Chargers Prediction

The Chargers are going to get the love from oddsmakers at home, and they’re the sexier team with the high-powered offense. However, I see value in the Broncos in the underdog role given they have one of the best defenses in the league, and they should be eager to rebound from a tough loss to the Colts. The Chargers have less time to prepare for this game, and they’re banged up on defense, with Denzel Perryman and Khalil Mack on the injury report. Four of the last 10 games between the Chargers and Broncos have been decided by 3 or fewer points. I want the points with the Broncos in a game they could win outright.