Buffalo Bills vs Carolina Panthers Prediction 10/26/2025 Today’s NFL Picks

In this article, we will formulate a Bills vs Panthers Prediction for this NFL Week 8 game on Sunday, October 26th. Let’s take a look at the prediction for this NFL matchup.

Carolina Panthers Preview

The Carolina Panthers have a 4-3 record this season and are sitting second in the NFC South. They are 5-2 ATS, 4-3 in Over/Under and have a 3-0 home record and a 1-3 away record. The Panthers are coming off a 13-6 road win against the New York Jets and will face the Packers, Saints and the Falcons next.

Offensively, the Panthers average 20.7 points per game, ranking 23rd in the NFL, while defensively, they allow 21.7 points per game, which is 12th. Carolina averages 326.7 total yards per game (186.6 passing and 140.1 rushing), while allowing 295.7 total yards per game (92.6 rushing and 203.1 passing).

Bryce Young leads the Panthers with 1288 passing yards with 61.6% completed passes and 11 touchdowns. Rico Dowdle leads the team in rushing yards with 551, while Tetairoa McMillan has a team-high 30 receptions for 413 receiving yards, and two touchdowns. Defensively, Christian Rozeboom has a team-high 50 total tackles (25 of them solo), while Derrick Brown leads the team in sacks, with 3.0, while Jaycee Horn has three interceptions.

Buffalo Bills Preview

The Buffalo Bills have a 4-2 record this season and are sitting second in the AFC East. They are 2-4 ATS, 3-3 in Over/Under and have a 3-1 home record and a 1-1 away record. The Bills are coming off a 14-24 road loss against the Atlanta Falcons and will face the Chiefs, Dolphins and the Buccaneers next.

Offensively, the Bills average 27.8 points per game, ranking 4th in the NFL, while defensively, they allow 22.8 points per game, which is 16th. Buffalo averages 378.3 total yards per game (227.3 passing and 151.0 rushing), while allowing 323.5 total yards per game (156.3 rushing and 167.2 passing).

Josh Allen leads the Bills with 1397 passing yards with 68.5% completed passes and 11 touchdowns. James Cook leads the team in rushing yards with 537, while Khalil Shakir has a team-high 25 receptions for 268 receiving yards, and two touchdowns. Defensively, Terrel Bernard has a team-high 30 total tackles (21 of them solo), while Ed Oliver leads the team in sacks, with 2.0, while Terrel Bernard and Cole Bishop each have one interception.

Buffalo Bills @ Carolina Panthers Betting Trends: Week 8

Why the Carolina Panthers will win

• The underdogs have won each of the Panthers’ last five games at Bank of America Stadium.
• The Bills have lost three of their last four games as road favorites.
• The underdogs have covered the spread in each of the Panthers’ last eight games at Bank of America Stadium.
• The Bills have failed to cover the spread in each of their last four games.
• The Bills have lost the first half in seven of their last eight road games against NFC South opponents.
• The Bills have lost the first quarter in each of their last four games as favorites following a loss.

Why the Buffalo Bills will win

• The Panthers have lost each of their last 11 games when playing with a rest disadvantage.
• The Bills have won each of their last 11 games as favorites when playing with a rest advantage.
• The Panthers have failed to cover the spread in each of their last nine games following a road win.
• The Bills have covered the spread in each of their last four games following a road loss.
• The Bills have scored the first touchdown in each of their last six Week 8 games.
• The Panthers have lost the first half in each of their last 13 games against teams that held a winning record.
• The Bills have won the first quarter in each of their last five Week 8 games.

Total Points Facts

• Nine of the Panthers’ last 10 games at Bank of America Stadium have gone OVER the total points line.
• Each of the Bills’ last four Week 8 games have gone UNDER the total points line.

Carolina Panthers Player Prop Facts

• Rico Dowdle has scored a touchdown in each of his last four home appearances.
• Bryce Young has recorded 191+ passing yards in each of the Panthers’ last five games as heavy underdogs (>+7.0 points).
• Chuba Hubbard has recorded 54+ rushing and receiving yards in each of his last 15 appearances against AFC opponents.
• Chuba Hubbard has recorded 43+ rushing yards in 13 of his last 14 appearances at Bank of America Stadium.
• Chuba Hubbard has recorded 13+ receiving yards in seven of his last eight appearances.
• Bryce Young has recorded 19+ completions in four of his five previous home appearances against AFC opponents.
• Heading into Week 8, Rico Dowdle ranks 1st amongst qualified players for Yards Per Carry (5.6) this season.

Buffalo Bills Player Prop Facts

• James Cook has scored two or more touchdowns in four of the Bills’ last five road games against teams that held a winning record.
• Josh Allen has scored at least one touchdown in each of the Bills’ last 13 games against teams on a winning streak.
• Josh Allen has recorded 41+ rushing yards in 10 of the Bills’ last 11 road games against NFC opponents.
• Josh Palmer has recorded 24+ receiving yards in each of his last 13 October appearances.
• Josh Allen has recorded 283+ passing yards in four of the Bills’ last five road games against NFC opponents.
• Curtis Samuel has recorded 22+ rushing and receiving yards in each of his last six October appearances against NFC opponents.
• Josh Allen has recorded 22+ completions in four of the Bills’ last five road games against NFC opponents.
• Heading into Week 8, James Cook is the only player in the NFL to record 100+ rushing yards in three or more consecutive games this season.

Matchup/League Facts

• Heading into Week 8, the Panthers rank 1st in the NFL in 4th down attempts (18) this season.
• Heading into Week 8, the Panthers rank 32nd in the NFL in Q2 opponent points per game (11.3) this season.
• Heading into Week 8, the Bills rank 1st in the NFL in rushing yards per game (151.0) this season.
• Heading into Week 8, the Bills rank 32nd in the NFL in average yards per punt (42.6) this season.

Bills vs Panthers Prediction

In their previous meeting in 2021, the Bills won 31-14 at home, and are 3-1 in their four meetings against the Panthers. Both teams are tied 1-1 in their two meetings in Carolina, and over/under is 2-2 in their four meetings. 

In this Bills vs Panthers Prediction, the Bills are coming as -7.5-point road favorites, with the total set at 45.5 points. Both teams are coming into this matchup in opposite trajectories, as the Panthers have three consecutive wins, and are a perfect 3-0 at home. On the flip side, the Bills have back-to-back losses, and have failed to cover the spread in their last 4 games. Buffalo has the 4th-best offense in the league this season, but are averaging just 17 points per game in their last two. I expect the hosts to keep this one close, so take the Carolina Panthers and the +7.5 points in this one.