Atlanta Falcons vs Arizona Cardinals Prediction 12/21/2025 Today’s NFL Picks

The Atlanta Falcons and Arizona Cardinals meet Sunday in NFL action at State Farm Stadium. Here’s a Atlanta Falcons vs Arizona Cardinals Prediction. This article will include a Atlanta Falcons vs Arizona Cardinals Pick.

Atlanta Falcons Betting Preview

The Atlanta Falcons lost to the Seahawks, beat the Buccaneers, and they play the Rams next. The Atlanta Falcons have lost 7 of their last 9 games. Kirk Cousins is completing 62.6 percent of his passes for 1,218 yards, 6 touchdowns, and 3 interceptions. Kyle Pitts and Drake London have combined for 1,607 receiving yards and 10 touchdowns, while Bijan Robinson has 64 receptions.

The Atlanta Falcons ground game is averaging 122.7 yards per contest, and Bijan Robinson leads the way with 1,174 yards and 6 touchdowns. Defensively, Atlanta is allowing 24.4 points and 323.6 yards per game. Kaden Elliss leads the Atlanta Falcons with 94 tackles, James Pearce Jr. has 8 sacks and Xavier Watts has 3 interceptions.

Arizona Cardinals Betting Preview

The Arizona Cardinals lost to the Rams and Texans, and play the Bengals next. The Arizona Cardinals have lost 6 straight games. Jacoby Brissett is completing 66.3 percent of his passes for 2,708 yards, 18 touchdowns, and 6 interceptions. Trey McBride and Michael Wilson have combined for 1,837 receiving yards and 14 touchdowns, while Marvin Harrison Jr. has 40 receptions.

The Arizona Cardinals ground game is averaging 95 yards per contest, and Bam Knight leads the way with 269 yards and 4 touchdowns. Defensively, Arizona is allowing 27.7 points and 351.1 yards per game. Budda Baker leads the Arizona Cardinals with 101 tackles, Josh Sweat has 11 sacks and Dadrion Taylor-Demerson has 2 interceptions.

Why the Arizona Cardinals will win

• The home team has won 17 of the last 18 games between the Falcons and Cardinals.
• The Falcons have lost each of their last four Sunday games as favorites.
• The Falcons have failed to cover the spread in 12 of their last 13 road games following a road win.
• The Cardinals have covered the spread in each of their last six games as underdogs against NFC South opponents.
• The Falcons have lost the first half in four of their last five road games following a road win.
• The underdogs have won the first quarter in each of the last two games between the Falcons and Cardinals.

Why the Atlanta Falcons will win

• The Cardinals have lost each of their last eight games played on the West Coast.
• The Falcons have won each of their last seven Week 16 games as favorites.
• The Cardinals have failed to cover the spread in each of their last four games without Marvin Harrison Jr..
• The Falcons have covered the spread in six of their last seven Week 16 games as favorites.
• The favorites have won the first half in five of the Cardinals’ last six games.
• The Falcons have won the first quarter in three of their last four road games against the Cardinals following a win.

Total Points Facts

• Each of the Cardinals’ last nine Sunday games at State Farm Stadium have gone OVER the total points line.
• Ten of the Falcons’ last 11 Week 16 games have gone UNDER the total points line.

Arizona Cardinals Player Prop Facts

• Trey McBride has scored at least one touchdown in five of the Cardinals’ last six games as underdogs against NFC opponents.
• Jacoby Brissett has recorded 249+ passing yards in each of the Cardinals’ last nine games as underdogs.
• Jacoby Brissett has recorded 25+ completions in seven of the Cardinals’ last eight Sunday games as underdogs.
• Michael Carter has recorded 18+ receiving yards in each of his last seven appearances with the Cardinals as underdogs following a loss.
• Michael Carter has recorded 28+ rushing and receiving yards in each of his last seven appearances with the Cardinals as underdogs following a loss.
• Michael Carter has recorded 18+ rushing yards in four of his last five December appearances.
• Heading into Week 16, Jacoby Brissett has recorded the most completions in a single game this season (47 vs 49ers, Week 11).

Atlanta Falcons Player Prop Facts

• Kirk Cousins has recorded 21+ completions in five of his six previous appearances against the Cardinals.
• Kirk Cousins has recorded 232+ passing yards in eight of his last nine appearances against NFC West opponents.
• Bijan Robinson has scored at least one touchdown in six of the Falcons’ last seven games as favorites against NFC opponents.
• Darnell Mooney has recorded 44+ receiving yards in six of the Falcons’ last seven games as favorites following a win.
• Darnell Mooney has recorded 44+ rushing and receiving yards in six of the Falcons’ last seven games as favorites following a win.
• Bijan Robinson has recorded 75+ rushing yards in each of the Falcons’ last six December games against NFC opponents.
• Heading into Week 16, Kyle Pitts has recorded the equal-most receiving touchdowns in a single game this season (3 vs Buccaneers, Week 15).

Matchup/League Facts

• Heading into Week 16, the Cardinals have suffered the most losses by a margin of five points or less this season (7).
• Heading into Week 16, the Cardinals have suffered the equal-most losses by a margin of three points or less this season (5).
• Heading into Week 16, the Falcons have suffered the equal-most losses when leading after Q1 this season (6).
• Heading into Week 16, the Falcons have played in the equal-highest number of games that went to overtime this season (2).

Atlanta Falcons vs Arizona Cardinals Prediction

It’s always tough to cap a game late in the season in matchups between two teams that have nothing to play for. It’s why I’m leaning toward the Falcons and the small number, as that was the case last week against the Buccaneers, and they still went into Tampa and left with an upset victory. The Falcons clearly haven’t given up on the season, and Cousins is coming off one of his better showings of the year.

The Cardinals have won one game since week 3 and are 1-5 ATS in their last 6 games. The Cardinals are also dealing with endless injuries. Receivers, quarterback, tackles, running backs, every week the injury report for Arizona gets longer and longer. Now, the Falcons have lost 4 straight games as a favorite, so tread lightly. Still, the Falcons should win this game, given they still have their competitive spirit.

Randy Chambers's Pick: Atlanta Falcons -2.5