Arizona Cardinals vs New Orleans Saints Prediction 9/7/2025 Today’s NFL Picks

In this article, we will formulate a Cardinals vs Saints Prediction for this NFL Week 1 game on Sunday, September 7th at the Caesars Superdome. Let’s take a look at the prediction for this NFL matchup.

New Orleans Saints Preview

New Orleans finished the preseason with a 0-2-1 record. They lost on the road by the Chargers 13-27, had a home tie against the Jaguars with a 17-17 score, and lost in Denver by the Broncos, 19-28.

Offensively, New Orleans finished the preseason averaging 16.3 points per game, while allowing 24.0 points per game defensively. New Orleans averaged 74.7 rushing yards and 215.7 passing yards per game. They allowed 115.7 rushing yards per game and 211.3 passing yards per game.

Tyler Shough led the Saints in the preseason with 36/54 completed passes and 333 total passing yards. He also had 1 touchdown and 1 interception. Spencer Rattler had 30/43 passes for 295 passing yards and 1 touchdown, while Jake Haener added 10/17 passes for 78 passing yards. Kendre Miller led the team in rushing yards, with 51, while Mason Tipton had a team-high 8 caught passes for 158 receiving yards, and had 1 touchdown. Dante Pettis caught 7 passes for 87 yards, and 1 touchdown.

Defensively, Jaylan Ford had a team-high 15 total tackles, 12 of them solo, while Khristian Boyd had a team-high 2 total sacks, and Jaylan Ford had a team-high 1 interception.

Arizona Cardinals Preview

Arizona finished the preseason with a 2-1 record. They won Kansas City at home by 20-17, lost in Denver by the Broncos, 7-27, and won Las Vegas at home by 20-10. 

Offensively, Arizona finished the preseason averaging 15.7 points per game, while allowing 18.0 points per game defensively. The Cardinals averaged 124.3 rushing yards and 128.7 passing yards per game. They allowed 120.7 rushing yards per game and 230.0 passing yards per game.

Jacoby Brissett led the Cardinals in the preseason with 11/16 completed passes and 138 total passing yards. He also had 3 touchdowns and 0 interceptions. Kyler Murray had 7/8 passes for 96 passing yards, while Clayton Tune added 5/9 passes for 47 passing yards. Michael Carter led the team in rushing yards, with 61, while Greg Dortch had a team-high 7 caught passes for 75 receiving yards.

Defensively, Owen Pappoe had a team-high 15 total tackles, 9 of them solo, while Tyreke Smith had a team-high 2.0 total sacks, and Sean Chandler had a team-high 1 interception.

Why the New Orleans Saints will win

• The Cardinals have lost each of their last four games as road favorites.
• The Saints have won each of their last six season openers.
• The underdogs have covered the spread in eight of the Cardinals’ last nine Week 1 games.
• The Cardinals have failed to cover the spread in each of their last four games as road favorites.
• The Cardinals have lost the first quarter in each of their last four games as favorites against NFC South opponents.
• The Cardinals have lost the first half in each of their last 10 road games against NFC South opponents.
• The Saints have scored the first touchdown in each of their last four Week 1 games.

Why the Arizona Cardinals will win

• The Saints have lost 10 of their last 11 Week 1 home games against NFC West opponents.
• The favorites have won each of the Saints’ last six games.
• The Cardinals have covered the spread in each of their last seven road games in September.
• The Saints have failed to cover the spread in each of their last four games as underdogs against NFC West opponents.
• The road team has won the first quarter in each of the last three games between the Cardinals and Saints.
• The road team has won the first half in eight of the Cardinals’ last nine Week 1 games.
• The Cardinals have scored the first touchdown in nine of their last 11 Sunday games as favorites.

Total Points Facts

• Eight of the Cardinals’ last nine road games in September have gone UNDER the total points line.
• Seven of the Saints’ last eight season openers against NFC opponents have gone OVER the total points line.
• Three of the last four Sunday games at Caesars Superdome have gone UNDER the total points line.

Matchup/League Facts

• Saints – two different players recorded 100+ rushing yards in a game last season – equal-most in the NFL.
• The Saints ranked 32nd in the NFL in H2 points per game (7.7) last season.
• Cardinals – six different players recorded 50+ rushing yards in a game last season – equal-most in the NFL.
• Cardinals – 17 different players recorded 1.0 sacks or more in a game last season – equal-most in the NFL.

Cardinals vs Saints Prediction

In their most recent meeting back in 2022, Arizona won 42-34 at home. The Saints are 5-3 in their 8 meetings against the Cardinals, and are 5-3 against the spread. The Saints have won all of their four home meetings against the Cardinals, and over is 6-2 in their 8 meetings.

In this Cardinals vs Saints Prediction, the Cardinals are coming as -6.5-point road favorites. The Saints rebuilt their secondary with Justin Reid and Julian Blackmon, plus rookie Jonas Sanker, giving them a strong safety group even after Tyrann Mathieu’s retirement. But rookie QB Spencer Rattler has won the starting job at quarterback over their second second-round round draft pick, Tyler Shough. Rattler was 0-6 as a starter last season, completing just 57% of his passes. The Saints went winless in the preseason, and are projected to be the worst team in the NFL this season. Take the Arizona Cardinals and lay the -6.5 points on the road.