Arizona Cardinals vs Indianapolis Colts Prediction 10/12/2025 Today’s NFL Picks

In this article, we will formulate a Cardinals vs Colts Prediction for this NFL Week 5 game on Sunday, October 12th at the Lucas Oil Stadium. Let’s take a look at the prediction for this NFL matchup.

Indianapolis Colts Preview

The Indianapolis Colts have a 4-1 record this season and are sitting in first place of the AFC South. They are 4-1 ATS, 2-3 in Over/Under and have a 1-1 away record and 3-0 home record. The Colts are coming off a 40-6 home win over the Las Vegas Raiders and are playing the Los Angeles Chargers, the Tennessee Titans and the Pittsburgh Steelers next.

Offensively, the Colts average 32.6 points per game, which ranks 2nd in the NFL. Defensively, they allow 17.8 points per game, which is 3rd. Indianapolis averages 381.2 total yards per game, with 128.2 rushing yards and 253 passing yards per game. They allow 315 total yards per game, with 98 rushing and 217 passing yards per game.

Daniel Jones leads the Colts with 1290 passing yards and 71.3% completed passes. Jonathan Taylor leads the team in rushing yards, with 480, while Michael Pittman Jr. has a team-high 26 caught passes for 273 receiving yards, and 4 touchdowns. Defensively, Zaire Franklin has a team-high 29 total tackles. Kwity Paye leads the Colts in sacks, with 3.0, while Camryn Bynum and Laiatu Latu have two interceptions.

Arizona Cardinals Preview

The Arizona Cardinals have a 2-3 record this season and are sitting in fourth place of the NFC West. They are 2-3 ATS, 2-3 in Over/Under and have a 1-1 away record and 1-2 home record. The Cardinals are coming off a 22-21 road loss to the Tennessee Titans and are playing the Green Bay Packers and the Dallas Cowboys next.

Offensively, the Cardinals average 20.6 points per game, which ranks 23rd in the NFL. Defensively, they allow 19.2 points per game, which is 4th. Arizona averages 288.4 total yards per game, with 118.2 rushing yards and 192.4 passing yards per game. They allow 346.6 total yards per game, with 92.4 rushing and 254.2 passing yards per game.

Kyler Murray leads the Cardinals with 962 passing yards and 68.3% completed passes. He also leads the team in rushing yards, with 173, while Trey McBride has a team-high 29 receptions for 275 receiving yards, and one touchdown. Defensively, Mack Wilson has a team-high 41 total tackles. Josh Sweat leads the Cardinals in sacks, with 5, while Dadrion Taylor-Demerson has two interceptions.

Arizona Cardinals @ Indianapolis Colts Betting Trends: Week 6

Why the Indianapolis Colts will win

• The Colts have won each of their last 10 games as home favorites against opponents on a losing streak.
• The Cardinals have lost five of their last six road games.
• The Colts have covered the spread in each of their last five games in October.
• The Cardinals have failed to cover the spread in each of their last three Week 6 games.
• The Cardinals have lost the first quarter in each of their last four road games in October.
• The Colts have scored the first touchdown in each of their last four games as favorites.
• The favorites have won the first half in each of the Cardinals’ last seven games.

Why the Arizona Cardinals will win

• The Colts have lost each of their last six games against NFC opponents on a losing streak.
• The Cardinals have won four of their last five games as underdogs against AFC opponents.
• The Cardinals have covered the spread in each of their last six games as underdogs against AFC opponents.
• The Colts have failed to cover the spread in each of their last four games against NFC opponents.
• The Colts have lost the first quarter in four of their last five October games as favorites.
• The Cardinals have scored the first touchdown in seven of their last eight games against AFC opponents.
• The Cardinals have won the first half in each of their last four Week 6 games against AFC opponents.

Total Points Facts

• Each of the Cardinals’ last five games as underdogs have gone UNDER the total points line.
• Each of the Colts’ last four games in October have gone UNDER the total points line.

Indianapolis Colts Player Prop Facts

• Jonathan Taylor has scored two or more touchdowns in each of the Colts’ last four games against teams on a losing streak.
• Daniel Jones has recorded 262+ passing yards in three of the Colts’ last four games following a win.
• Jonathan Taylor has scored at least one touchdown in each of his seven previous appearances with the Colts as home favorites against teams on a losing streak.
• Daniel Jones has recorded 26+ rushing yards in each of his last seven appearances with his team as a favorite against NFC opponents.
• Michael Pittman Jr. has recorded 63+ receiving yards in each of the Colts’ last eight games as favorites following a win.
• Jonathan Taylor has recorded 118+ rushing and receiving yards in each of the Colts’ last four games as moderate favorites (-3.5 to -7.0 points).
• Daniel Jones has recorded 22+ completions in seven of his last eight appearances following a win.
• Heading into Week 6, Jonathan Taylor ranks 1st in the NFL in rushing yards (480) this season.

Arizona Cardinals Player Prop Facts

• Marvin Harrison Jr. has scored a touchdown in three of the Cardinals’ last four Sunday games as underdogs.
• Jacoby Brissett has recorded 233+ passing yards in three of his last four October appearances with his team as a road underdog.
• Jacoby Brissett has recorded 20+ rushing yards in three of his last four appearances with his team as a road underdog against AFC South opponents.
• Marvin Harrison Jr. has recorded 63+ receiving yards in each of the Cardinals’ last four games following a loss.
• Heading into Week 6, Josh Sweat ranks T3rd in the NFL in sacks (5.0) this season.

Matchup/League Facts

• Colts – one different players have recorded 100+ rushing yards in a game this season – equal-most in the NFL, heading into Week 6.
• Colts – seven different players have recorded 50+ receiving yards in a game this season – most in the NFL, heading into Week 6.
• Heading into Week 6, the Cardinals rank T1st in the NFL in 4th down percentage (100.0%) this season.
• Heading into Week 6, the Cardinals rank 1st in the NFL in Q3 opponent points per game (1.8) this season.

Cardinals vs Colts Prediction

In their previous meeting in 2021, the Colts won 22-16 on the road. Both teams are tied 2-2 wins in their four meetings, with the Cardinals having won their only visit in Indianapolis. Under is 3-1 in their four meetings.  

In this Cardinals vs Colts Prediction, the Colts are coming as -7-point home favorites, with the total set at 47 points. The Colts have been almost perfect this season, having lost only once in their five games played, and are a perfect 3/3 at home, having covered the spread in all three. On the flip side, the Cardinals have three consecutive wins after winning their first two games of the season, and are 1-3 ATS in their last 4 games. The Colts are better both offensively and defensively, and I expect them to get the job done at home today. The play here is the Indianapolis Colts by -7 points.