Arizona Cardinals vs Denver Broncos Prediction 8/16/2025 Today’s NFL Picks

The Arizona Cardinals and the Denver Broncos meet in week 2 NFL Preseason action from Empower Field at Mile High on Saturday. We will look at this from a betting perspective and determine the best bets for this game. Here’s an Arizona Cardinals vs. Denver Broncos prediction.

Arizona Cardinals Recap

The Arizona Cardinals come into this game looking to add on to their 20-17 win over the Kansas City Chiefs last time out to start the preseason 1-0. After this game, the Cardinals will head home to finish their preseason against the Las Vegas Raiders.

Cardinals Looking To Tighten Things Up In Week 2

Kyler Murray threw for 96 yards and an interception on 7 of 8 passing while Jacoby Brissett had 81 passing yards and a pair of TDs on 5 of 8 passing. Clayton Tune also went 5 of 9 with an interception and 47 yards through the air while Bam Knight had a team-high 51 rushing yards and Trey Benson used his team-high 9 carries for 29 rushing yards. Emari Demercado had a team-high 56 receiving yards with a TD while Xavier Weaver had a TD grab as well in the win. On defense, Jammie Robinson led the Cards with 6 total tackles including 4 solo tackles while L.J. Collier had a sack and Darren Hall and Kitan Crawford each had an interception in the victory.

Denver Broncos Recap

The Denver Broncos come into this game looking to add on to their 30-9 blowout win over San Francisco last time out to sit at 1-0 in the preseason. After this game, the Broncos will head on the road for a game against New Orleans to close out the preseason.

Broncos Have Dominant Showing In Week 1

Jarrett Stidham threw for 136 yards and 2 TDs on 14 of 15 passing while Sam Ehlinger threw for 55 yards and a TD on 6 of 10 passing and Bo Nix went 6 of 11 for 31 yards. Stidham also led the Broncos with 36 rushing yards while Tyler Badie had 32 rushing yards on his 5 carries. Trent Sherfield Sr. led the Broncos with 3 grabs for 73 yards and a TD while Blake Watson had 3 grabs of his own and Lucas Krull and Caden Prieskorn each had a touchdown reception in the winning effort. On defense, Jordan Jackson led Denver with 6 total tackles while Nik Bonitto and John Franklin-Myers each had a sack. Karene Reid, Ja’Quan McMillian and Joshua Pickett each had an interception as well in the win.

Arizona Cardinals vs. Denver Broncos Prediction

I’m leaning towards the Cardinals and the points here. I just think Arizona matches up better with Denver with their QB depth, and the Broncos didn’t have much of a test in the San Francisco 49ers, a team that I’m not fond of from a depth perspective especially at QB. Arizona was able to run 3 QBs deep in week 1 and I just think this is going to be a closer game if Arizona doesn’t find a way to win it outright. Give me the Cardinals and the points here.