Arizona Cardinals vs San Francisco 49ers Prediction NFL Picks 10/6/24

San Francisco 49ers (2-2) vs Arizona Cardinals (1-3)

Game Info: Sunday, October 6, 2024 at 4:05 pm (Levi's Stadium)

Betting Odds: San Francisco 49ers -7.5 / Arizona Cardinals +7.5 --- Over/Under: 50 Click Here for the Latest Odds

The Arizona Cardinals and San Francisco 49ers meet Sunday in week 5 NFL action at Levi's Stadium. Here’s an Arizona Cardinals vs San Francisco 49ers Prediction. This article will include an Arizona Cardinals vs San Francisco 49ers Pick.

Arizona Cardinals Betting Preview

The Arizona Cardinals lost to the Lions and Commanders, and play the Packers next. The Arizona Cardinals have lost 8 of their last 10 road games. Kyler Murray is completing 69.4 percent of his passes for 777 yards, 6 touchdowns, and 1 interception. Marvin Harrison Jr. and Michael Wilson have combined for 381 receiving yards and 5 touchdowns, while Greg Dortch has 15 receptions.

The Arizona Cardinals ground game is averaging 153.3 yards per contest, and James Conner leads the way with 293 yards and 3 touchdowns. Defensively, Arizona is allowing 26.5 points and 354.8 yards per game. Budda Baker leads the Arizona Cardinals with 39 tackles, Dennis Gardeck has 3 sacks and Dennis Gardeck has 1 interception.

San Francisco 49ers Betting Preview

The San Francisco 49ers lost to the Rams, beat the Patriots, and play the Seahawks next. The San Francisco 49ers have won 7 of their last 10 home games. Brock Purdy is completing 68.9 percent of his passes for 1,130 yards, 5 touchdowns, and 2 interceptions. Jauan Jennings and Deebo Samuel have combined for 586 receiving yards and 3 touchdowns, while Brandon Aiyuk has 13 receptions.

The San Francisco 49ers ground game is averaging 141.8 yards per contest, and Jordan Mason leads the way with 447 yards and 3 touchdowns. Defensively, San Francisco is allowing 20.5 points and 295.3 yards per game. Fred Warner leads the San Francisco 49ers with 27 tackles, Kevin Givens has 3.5 sacks and Demetrius Flannigan-Fowles has 1 interception.

Why the San Francisco 49ers will win

  • The 49ers have won each of their last 10 home games following a home win.
  • The Cardinals have lost each of their last eight games as underdogs against NFC West opponents.
  • The Cardinals have failed to cover the spread in each of their last five road games in October.
  • The 49ers have covered the spread in nine of their last 10 home games following a home win.
  • The Cardinals have lost the first half in nine of their last 10 games against NFC opponents.
  • The Cardinals have lost the first quarter in four of their last five October games against NFC opponents.

San Francisco 49ers Player Prop Facts

  • Brock Purdy has thrown two or more touchdowns in seven of his last eight regular-season appearances with the 49ers as home favorites against NFC opponents.
  • Christian McCaffrey has scored at least one touchdown in 20 of his last 21 appearances with the 49ers as favorites following a win.
  • Jauan Jennings has recorded 37+ receiving yards in each of the 49ers' last five games.
  • Brock Purdy has recorded 11+ rushing yards in each of the 49ers' last seven games.
  • Christian McCaffrey has recorded 131+ rushing and receiving yards in each of his last seven appearances following a win.
  • Christian McCaffrey has scored two or more touchdowns in three of his last four appearances with the 49ers as favorites against NFC West opponents.
  • Brock Purdy has recorded 252+ passing yards in each of the 49ers' last eight games at Levi's Stadium as heavy favorites (>-7.0 points).
  • Brock Purdy has recorded 22+ completions in four of his last five appearances with the 49ers as favorites against NFC opponents.
  • Jauan Jennings has recorded the most receiving yards in a single game this season (175 vs Rams, Week 3).

Arizona Cardinals Player Prop Facts

  • Kyler Murray has thrown two or more touchdowns in eight of his last nine regular-season appearances with the Cardinals as road underdogs against NFC opponents.
  • James Conner has scored at least one touchdown in nine of his last 10 appearances following a home loss.
  • Zay Jones has recorded 40+ receiving yards in five of his last six appearances with his team as an underdog following a loss.
  • Kyler Murray has recorded 49+ rushing yards in four of his last five appearances against the 49ers.
  • James Conner has recorded 89+ rushing and receiving yards in six of the Cardinals' last seven games against NFC opponents.
  • Kyler Murray has recorded 256+ passing yards in four of his last five regular-season appearances with the Cardinals as underdogs against NFC West opponents.
  • Kyler Murray has recorded 23+ completions in each of his last six regular-season appearances with the Cardinals as road underdogs against NFC opponents.
  • Jalen Thompson is just one away from 10 career interceptions.

Matchup/League Facts

  • The 49ers are the only team to average over 250.0 passing yards and 125.0 rushing yards this season.
  • The 49ers rank 1st in the NFL in time of possession per game (34:37) this season.
  • The Cardinals rank 3rd in the NFL in average kickoff return (31.6 yards) this season.
  • The Cardinals rank 3rd in the NFL in Q1 points per game (8.8) this season.

Arizona Cardinals vs San Francisco 49ers Prediction

The San Francisco 49ers are slowly getting players back from injury, and we know what they're capable of when they're firing on all cylinders. The Arizona Cardinals haven't looked great on either side of the ball these last two weeks, and the offense has been one-dimensional with a limited passing game. A talented and physical 49rs defense should have its way with this Cardinals offense. Also, the Cardinals have allowed 30-plus points in two of their first four games and can't stop the run. The 49ers have won 4 straight games against the Cardinals and have covered double-digit chalk in all of those games. The number isn't as large this time, but I still expect a double-digit win from the 49ers.

Randy’s Pick San Francisco 49ers -7.5

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

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NFL Week 5 2024 Picks & Predictions | Picks From The DawgHouse NFL Edition

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