San Francisco 49ers vs LA Rams Prediction NFL Picks 9/22/24

LA Rams (0-1) vs San Francisco 49ers (1-0)

Game Info: Sunday, September 22, 2024 at 4:25 pm (SoFi Stadium)

Betting Odds: LA Rams +7 / San Francisco 49ers -7 --- Over/Under: 46.5 Click Here for the Latest Odds

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The San Francisco 49ers and the Los Angeles Rams meet in week 3 NFL action from SoFi Stadium on Sunday afternoon. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco 49ers vs. Los Angeles Rams prediction.

San Francisco 49ers Recap

The San Francisco 49ers come into this one looking to bounce back after a 23-17 loss to the Minnesota Vikings to fall to 1-1 on the year. After this game, the 49ers will head home to welcome the Patriots to town.

49ers Trying To Bounce Back

Brock Purdy has thrown for 550 yards, a touchdown, and an interception on 72.3% passing while Jordan Mason has rushed for 247 yards and 2 touchdowns on the ground. Deebo Samuel leads the 49ers receiving group with 13 grabs for 164 yards while George Kittle has 11 receptions for 116 yards and a touchdown and Jauan Jennings has 101 receiving yards as well. On defense, Fred Warner leads the 49ers with 16 total tackles including 12 solo tackles and a sack along with an interception while Nick Bosa has a pair of sacks. As a unit, San Francisco has combined for 5 sacks and a pair of interceptions so far this season.

Why the San Francisco 49ers will win

  • The 49ers have won 12 of their last 13 games against NFC West opponents.
  • The Rams have lost each of their last four games in September.
  • The 49ers have covered the spread in each of their last five games against the Rams following a loss.
  • The Rams have failed to cover the spread in each of their last five games as underdogs following a loss.

Los Angeles Rams Recap

The Los Angeles Rams will be out to rebound themselves after falling to 0-2 with a 41-10 loss to Arizona last time out. After this matchup, The Rams will go back on the road to square off with the Chicago Bears at Soldier Field.

Rams Still Searching For First Win

Matthew Stafford has thrown for 533 yards, a touchdown, and an interception on 69.7% passing while Kyren Williams leads the Rams with 75 rushing yards. Cooper Kupp leads the Rams’ receiving corps with 18 grabs for 147 yards and a touchdown with a team-high 18 receptions this season. On defense, Quentin Lake leads the 49ers with 21 total tackles including 11 solo tackles while the Chargers’ defense as a whole has combined for 3 sacks and an interception.

Why the Los Angeles Rams will win

  • The 49ers have lost each of their last six Week 3 games against NFC West opponents.
  • The Rams have won each of their last five games in California.
  • The 49ers have failed to cover the spread in seven of their last eight games in California.
  • The Rams have covered the spread in each of their last four games in California.

49ers vs. Rams Prediction

I’m on the 49ers here. This is a massive number for sure for a road favorite, especially after all of the big favorites on the board got crushed last week, but the Rams are so banged up, with Nacua on the IR, Cooper Kupp banged up, and this offensive line being held together by duct tape. The 49ers have injuries of their own to guys like CMC, but I feel like the 49ers are in a much better place and just got caught reading into their own hype when they lost to Minnesota. I think the 49ers bounce back here and I think the Rams are in some hot water here. Give me San Francisco.

Chris’s Pick San Francisco -7

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The pick in this article is the opinion of the writer, not a PickDawgz site consensus.

Mitch's Take...

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