Detroit Lions vs Arizona Cardinals Prediction NFL Picks 9/22/24

Recent betting trends and streaks involving the Detroit Lions

Recent betting trends and streaks involving the Arizona Cardinals

Recent betting trends in games played between the Lions and Cardinals

A summary that ties it all together and produces a favorable betting outcome for the Lions vs Cardinals game

Detroit Lions Betting Preview

In Week 1 the Lions took on the Los Angeles Rams. It took overtime to get there but Detroit ultimately came away with a 26-20 victory. QB Jared Goff logged 217 yards, one TD, and one pick. David Montgomery had 91 yards and a TD rushing, while Jameson Williams caught five balls for 121 yards and a score.

In Week 2 versus the Tampa Bay Buccaneers, the Lions were down 13-6 by the end of the first half. Detroit got slightly better from there but ultimately lost 20-16. Goff had 307 yards and two interceptions this time. Amon-Ra St. Brown caught 11 balls for 119 yards to lead the receivers.

Arizona Cardinals Betting Preview

Over on the Cardinals’ side, their first action of the year came versus the Buffalo Bills. Arizona held a 17-10 lead by the break but ultimately fell 34-28 after a rough second half. QB Kyler Murray finished with 162 yards and a TD through the air while also leading the rush with 57 yards.

Facing the Los Angeles Rams in game two, the Cardinals stormed out to a 24-3 halftime edge and powered out a 41-10 victory. Murray threw for 266 yards and three touchdowns. James Conner had 122 yards and a score off 21 totes, and Marvin Harrison had four catches for 130 yards and two scores.

Total Points Facts

• Eight of the Cardinals' last nine games at State Farm Stadium have gone OVER the total points line.
• Five of the Lions' last six road openers have gone OVER the total points line.

Arizona Cardinals Player Prop Facts

• James Conner has recorded 73+ rushing yards in seven of the Cardinals' last eight home games against NFC opponents.
• James Conner has recorded 83+ rushing and receiving yards in each of the Cardinals' last seven games.
• James Conner has scored at least one touchdown in each of the Cardinals' last seven Sunday games.
• Kyler Murray has recorded 241+ passing yards in each of his last six September home appearances against NFC opponents.
• Elijah Higgins has recorded 12+ receiving yards in each of the Cardinals' last eight Sunday games.
• Kyler Murray has recorded 23+ completions in 10 of his last 12 regular season appearances with the Cardinals as underdogs against NFC opponents.
• Kyler Murray has thrown two or more touchdowns in four of his last five appearances in September at State Farm Stadium.
• Marvin Harrison Jr. ranks 1st amongst qualified players for Yards Per Reception (26.8) this season.

Detroit Lions Player Prop Facts

• David Montgomery has recorded 67+ rushing and receiving yards in nine of his last 10 September appearances with his team as a favorite.
• Jahmyr Gibbs has recorded 60+ rushing yards in each of the Lions' last four games as road favorites.
• David Montgomery has scored a touchdown in seven of the Lions' last eight games.
• Jared Goff has recorded 271+ passing yards in six of the Lions' last seven games against NFC opponents.
• David Montgomery has recorded 10+ receiving yards in each of his four previous regular season road appearances against NFC West opponents.
• Jared Goff has recorded 24+ completions in three of his last four September appearances against NFC West opponents.
• Jared Goff has thrown three touchdowns in two of the Lions' last three September games against NFC West opponents.
• Carlton Davis is just one away from 10 career interceptions.

Detroit Lions vs Arizona Cardinals Prediction

I’m going with Arizona. Outside of a lost fumble, the Cardinals' offense was cooking in their last matchup with the Rams. Arizona bagged 489 yards (231 rushing), 7.9 yards per play, 24 first downs, and a 7-of-11 rate on third-down tries. Defensively the Cards held LA to just 245 yards (192 passing) and 2-of-11 on thirds in a dominant display.

As for Detroit, they posted 463 yards (324 passing) and 26 first downs against Tampa Bay. The defensive statistics were good as well: 216 yards (146 passing) and 14 first downs allowed alongside 2-of-10 in third-down efficiency. The Lions still found a way to lose, however. Specifically, Goff wasn’t at his best. I like Detroit to bounce back and give Arizona a game Sunday but I don’t quite think they’ll cover.