San Antonio Spurs vs Memphis Grizzlies Prediction 3/25/2026 Today’s NBA Picks

The San Antonio Spurs travel to the FedExForum to take on the Memphis Grizzlies on Wednesday night. Here’s a San Antonio Spurs vs. Memphis Grizzlies Prediction. This article will include a San Antonio Spurs vs. Memphis Grizzlies Pick.

San Antonio Spurs Betting Preview 

The San Antonio Spurs have been on fire, as they’ve won 22 of their last 24 games and they will be gunning for a seventh straight victory after making light work of the Heat in a 136-111 road win on Monday. Victor Wembanyama led the team with 26 points, 15 rebounds and five blocks. Keldon Johnson and Dylan Harper scored 21 points apiece, while Stephon Castle chipped in with 19 points, seven rebounds and six assists.

As a team, the Spurs shot 48 percent from the field and 15 of 43 from the 3-point line as they hit the ground running with 76 points in the first half and they just didn’t take their foot off the gas until the lead swelled to 30 points. The Spurs pulled their starters early but they really flexed their depth with Johnson and Harper playing well off the bench.

Memphis Grizzlies Betting Preview 

Meanwhile, the Memphis Grizzlies have been in a major slump, as they’ve lost 11 of their last 12 games overall and they will be hoping to arrest a three-game slide after getting smashed by the Hawks in a 146-107 road defeat on Monday. GG Jackson led the team with 26 points on nine of 14 shooting, Tyler Burton added 20 points off the bench, and Ty Jerome chipped in with 17 points.

As a team, the Grizzlies shot 42 percent from the field and 14 of 43 from the 3-point line, which aren’t terrible shooting numbers, but they just had no chance in this one after allowing 71 points in the first half, followed by another 45 points in the third quarter. 

Why the Memphis Grizzlies will win

• The Grizzlies have won seven of their last eight night games against the Spurs following a road loss.
• The Spurs have lost eight of their last 10 night games at FedExForum.
• The Grizzlies have covered the spread in five of their last six games against Western Conference opponents.
• The Spurs have failed to cover the spread in eight of their last 10 road games against Southwest Division opponents following a win.

Why the San Antonio Spurs will win

• The Spurs have won each of their last eight night games following a road win.
• The Grizzlies have lost 10 of their last 11 games against teams that held a winning record.
• The Spurs have covered the spread in each of their last four games against Southwest Division opponents.
• The Grizzlies have failed to cover the spread in four of their last five games as underdogs following a road loss.

Total Points Facts

• Five of the Grizzlies’ last six games against Southwest Division opponents have gone UNDER the total points line.
• Four of the Spurs’ last five road games against Western Conference opponents have gone OVER the total points line.

San Antonio Spurs vs Memphis Grizzlies Prediction

The Spurs have ruled out De’Aaron Fox and Luke Kornet, while the Grizzlies have ruled out Ty Jerome, Santi Aldama, Scotty Pippen Jr., and Brandon Clarke, to name a few. The past three meetings between these teams have been relatively close, with the largest margin of victory being just 10 points, but the Spurs open as heavy favorites in this one, which surprises no one. The Grizzlies’ injury list is still growing and their depth is severely stretched, so I will be surprised if they can keep this game close at all. Give me the surging Spurs to continue their hot streak with another win and cover in this one.

Peter Tran's Pick: San Antonio -16.5