Apr 4, 2026; Philadelphia, Pennsylvania, USA; Philadelphia 76ers guard Kelly Oubre Jr. (9) is defended by Detroit Pistons forward Paul Reed (7) during the second half at Xfinity Mobile Arena. Mandatory Credit: Eric Hartline-Imagn Images
IMAGN IMAGES via Reuters Connect

Pistons vs 76ers Prediction 10/25/2026 Today’s NBA Picks

Pick details

Detroit vs Philadelphia Odds and Matchup Info
MATCHUP Detroit Pistons Philadelphia 76ers
Team Records 2-0 3-0
Spread +2.5 -105 -2.5 -115
Moneyline +120 -142
Total Over 226.5 (-110) Under 226.5 (-110)
Where Xfinity Mobile Arena, Philadelphia, PA
When Sunday, October 25, 2026
Time 07:30 PM EDT
TV NBA League Pass

The Detroit Pistons and Philadelphia 76ers meet Sunday in NBA action at the Xfinity Mobile Arena. Here’s a Pistons vs. 76ers Prediction. This article will include a Pistons vs. 76ers pick.

Detroit Pistons Betting Preview


The Detroit Pistons beat the Celtics and Heat, and they play the Knicks next. The Pistons have won 8 of their last 9 games.

The Detroit Pistons are averaging 124.5 points on 49.1 percent shooting and allowing 112 points on 41.6 percent shooting. Duncan Robinson is averaging 19 points and 1.5 rebounds, while Cade Cunningham is averaging 19 points and 8 assists. John Collins is the third double-digit scorer, and Jalen Duren is grabbing 7.5 rebounds. The Detroit Pistons are shooting 42.3 percent from beyond the arc and 84.6 percent from the free-throw line. The Detroit Pistons are allowing 34.4 percent shooting from deep and are grabbing 51 rebounds per game.

76ers Betting Preview


The Philadelphia 76ers beat the Bucks and Cavs, and they play the Pacers next. The 76ers have won 12 of their last 17 regular season games.

The Philadelphia 76ers are averaging 115.7 points on 42.7 percent shooting and allowing 107.3 points on 42.8 percent shooting. Tyrese Maxey is averaging 28.7 points and 5 assists, while Jaylen Brown is averaging 22.3 points and 6.3 rebounds. Joel Embiid is the third double-digit scorer, and LeBron James is grabbing 9.5 rebounds. The Philadelphia 76ers are shooting 33 percent from beyond the arc and 79.1 percent from the free-throw line. The Philadelphia 76ers are allowing 30.2 percent shooting from deep and grabbing 43 rebounds per game.

Why the Philadelphia 76ers will win

  • The 76ers have won each of their last nine games as favorites on the second leg of a back-to-back.
  • The Pistons have lost 11 of their last 13 games at Xfinity Mobile Arena against 76ers teams that held a winning record.
  • The Pistons have failed to cover the spread in 12 of their last 13 games at Xfinity Mobile Arena against 76ers teams that held a winning record.
  • The 76ers have covered the spread in 12 of their last 14 games as home favorites against the Pistons.

Why the Detroit Pistons will win

  • The Pistons have won each of their last nine night games against Atlantic Division opponents that held a winning record.
  • The 76ers have lost each of their last nine Sunday night games against Eastern Conference opponents that held a winning record.
  • The Pistons have covered the spread in each of their last six night games against Atlantic Division opponents that held a winning record.
  • The 76ers have failed to cover the spread in four of their last five games when playing with a rest disadvantage.

Total Points Facts

  • Each of the Pistons’ last four games as road underdogs against opponents who are on the second leg of a back-to-back have gone OVER the total points line.
  • Four of the 76ers’ last five home games against the Pistons have gone UNDER the total points line.

Philadelphia 76ers Player Facts

  • VJ Edgecombe rank T5th amongst qualified Guards for total steals + blocks (7) this season.
  • Adem Bona leads all 76ers players for blocks per 36 minutes (2.2) this season.

Detroit Pistons Player Facts

  • John Collins ranks T2nd amongst qualified Centers for three-pointers made per game (2.5) this season.
  • Cade Cunningham ranks T3rd in the Eastern Conference amongst qualified players for blocks per game (2.0) this season.

Matchup/League Facts

  • The 76ers have recorded the largest comeback win from a Q1 deficit this season – trailed by 17 points @ Cavaliers on October 22.
  • The 76ers rank 1st in the league for H2 opponent points per game this season (45.0).
  • The Pistons rank 1st in the league for H2 points per game this season (69.5).
  • The Pistons rank T1st in the league for Q3 win percentage this season (100.0%).

Pistons vs 76ers Prediction


The 76ers are going to get the benefit of the doubt because they’ve become the popular public team with their additions. However, the value is with the Pistons and the free bucket, as you’re not going to get them as underdogs often with the way they win games and were just the best team in the East last season. LeBron is dealing with a back issue, and the 76ers are on the end of a back-to-back. You don’t want to see this Pistons defensive pressure after playing last night. The Pistons are 5-0 SU and 4-1 ATS in the last 5 games against the 76ers. Obviously a different team, but the Pistons can beat anybody night to night. Give me the bucket.

Randy Chambers's Pick: Detroit +2.5

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