White Sox vs Tigers Prediction 9/6/2025 Today’s MLB Picks

In this article we will formulate a White Sox vs Tigers prediction for this MLB game on Saturday, September 6th at Comerica Park in Detroit, Michigan. Let’s take a look at the prediction for this MLB matchup. 

Chicago White Sox Betting Preview

The Chicago White Sox are 54-88 this year after they won game one by a score of 7-5 on Friday night. Chicago trailed 4-3 in the fourth inning, but they scored the next four runs, which was enough to escape with the victory. The White Sox recorded 11 hits in the game and they were led by Montgomery, who went 2-4 with one home run and four RBIs in the win. Chicago started Smith, who allowed three hits and four earned runs over 5.0 innings for the win, while Leasure picked up the save. 

Prior to this series, the White Sox won all four against the Twins, but did lose three out of four against the Yankees before that. Chicago has won six games in a row and they are last in the AL Central standings. The Chicago pitching staff has a 4.23 ERA with a 1.37 WHIP and a .249 opponent batting average, while the offense has scored 576 runs with a .236 batting average and a .305 on base percentage this season. Lenyn Sosa has led Chicago with 19 home runs and 62 RBIs, while Andrew Benintendi has added 18 home runs and 56 RBIs this year. The projected starting pitcher for Chicago is Martin Perez, who is 1-3 with a 2.16 ERA and a 0.98 WHIP over 41.2 innings pitched this year. 

Detroit Tigers Betting Preview

The Detroit Tigers are 81-61 this season after they lost game one by a score of 7-5 last night. Detroit led 4-3 in the fourth inning, but they didn’t score again until the eighth, which was too late for the loss. The Tigers recorded seven hits and they committed one error in the game, while they were led by Meadows, who went 1-1 with one home run and two RBIs in the loss. Detroit started Flaherty, who allowed six hits and four earned runs over 4.1 innings, while Horn picked up the loss in relief. 

Prior to this series, the Tigers lost two out of three against the Mets, but did win two out of three against the Royals before that. Detroit has lost eight of their last eleven games and they are currently first in the AL Central standings. The Detroit pitching staff has a 3.91 ERA with a 1.24 WHIP and a .241 opponent batting average, while the offense has scored 685 runs with a .251 batting average and a .320 on base percentage this season. Riley Greene has led Detroit with 32 home runs and 103 RBIs, while Spencer Torkelson has added 28 home runs and 72 RBIs this year. The projected starting pitcher for Detroit is Tarik Skubal, who is 12-4 with a 2.18 ERA and a 0.87 WHIP over 173.0 innings pitched this season. 

Why the Tigers will beat the White Sox 

The Tigers have won nine of their last 10 games against AL Central opponents following a loss.
The White Sox have lost each of their last seven Saturday night games against American League opponents that held a winning record.
The White Sox have failed to cover the run line each of their last seven Saturday night games against American League opponents that held a winning record.
The Tigers have covered the run line in three of their last four games following a loss.

Total Runs Facts

Six of the Tigers’ last seven home games against AL Central opponents have gone OVER the total runs line.
Six of the White Sox’s last seven games as underdogs against AL Central opponents have gone OVER the total runs line.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in five of the Tigers’ last six games as home favorites.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in four of the White Sox’s last five night games at Comerica Park.

Detroit Tigers Player Prop Facts

Spencer Torkelson has recorded at least one hit in each of the Tigers’ last 15 games at Comerica Park against AL Central opponents that held a losing record.
Tarik Skubal has recorded a win in each of his five previous appearances with the Tigers as favorites against the White Sox.
Kerry Carpenter has hit a home run in four of the Tigers’ last six games at Comerica Park against AL Central opponents that held a losing record.
Spencer Torkelson has recorded a Double in each of the Tigers’ last three games against the White Sox at Comerica Park.

Chicago White Sox Player Prop Facts

Andrew Benintendi has hit a home run in each of the White Sox’s last two games against AL Central opponents that held a winning record.
Martin Perez has recorded five or more strikeouts in each of his last three appearances.
Andrew Benintendi has recorded at least one hit in each of his last seven appearances in night games against teams that held a winning record.

White Sox vs Tigers Prediction 

Detroit lost another game on Friday night to start this series and they have been pretty bad over the last two weeks. The Tigers are 45-28 at home this year, while the White Sox are 24-46 on the road. Chicago has won six games in a row and they are starting Perez, who has allowed two earned runs or fewer in three straight starts. Detroit is starting Skubal, who has allowed a total of one earned run in his last 20.2 innings of work. Take the Tigers by at least two runs in this one.