Washington Nationals vs Seattle Mariners Prediction 5/28/25 MLB Picks

The Washington Nationals and the Seattle Mariners meet Wednesday in MLB action from T-Mobile Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Washington Nationals vs. Seattle Mariners prediction.

Starting Pitching Matchup

The Washington Nationals will send Trevor Williams for the start here, and Williams is 2-5 with a 6.39 ERA and 41 strikeouts this season. In his career, Williams is 0-0 with a 4.00 ERA and 12 strikeouts against the Mariners. George Kirby will get the start for the Mariners here and is 0-1 with a 12.27 ERA and 4 strikeouts this season. In his career, Kirby is 0-1 with a 4.15 ERA and 12 strikeouts against Washington.

Washington Nationals Recap

The Washington Nationals come into this game looking to bounce back from a 9-1 loss at the hands of the Mariners on Tuesday to fall to 24-30 on the year. After this series, the Nationals will head on the road for a series against the Arizona Diamondbacks.

Nationals Drop Back-To-Back Games

Keibert Ruiz has 49 hits with 9 doubles and a pair of home runs with 20 RBIs, while James Wood has 57 hits with 13 doubles and a team-high 13 home runs, along with 36 RBIs and 7 stolen bases while also putting up 61 strikeouts. Nathaniel Lowe has 45 hits with 9 doubles and 34 RBIs, along with 8 home runs and 61 strikeouts. CJ Abrams has 8 home runs and 19 RBIs along with 10 doubles and 9 stolen bases, while Luis Garcia Jr. has 9 doubles and 7 stolen bases of his own this season. Dylan Crews has also logged a team-high 11 stolen bases this season.

Why the Washington Nationals will win

• The Mariners have lost four of their last five games as favorites following a win.
• The Nationals have won four of their last five games as underdogs against AL West opponents following a loss.
• The Nationals have covered the run line in each of their last 10 games against AL West opponents following a road loss.
• The Mariners have failed to cover the run line in 10 of their last 11 games as favorites after playing the previous day.

Washington Nationals Player Prop Facts

• Nathaniel Lowe has hit a home run in two of his last three appearances against AL West opponents.
• Trevor Williams has recorded a win in six of his last seven appearances in night games against teams that held a winning record.
• Luis Garcia has recorded at least one RBI in four of his last five road appearances after playing the previous day.
• Trevor Williams has recorded five or more strikeouts in three of his last four appearances with the Nationals as underdogs against AL opponents.
• Nathaniel Lowe has recorded at least one Single in each of his last six appearances in night games against AL West teams that held a winning record.
• Amed Rosario has recorded a Double in four of his last five appearances against opponents that held a winning record.
• Amed Rosario has recorded at least one hit in each of his last nine appearances with the Nationals as underdogs.
• Paul DeJong has scored a run in four of his last five appearances against AL West opponents that held a winning record.
• James Wood ranks T8th in the league in Home Runs (14) this season.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to build on their win over the Nationals last time out to step up to 30-23 on the year. After this series, the Mariners will take on the Minnesota Twins in a home series.

Mariners Trying To Build Some Steam

Jorge Polanco has 37 hits, including 10 home runs and 30 RBIs, while Cal Raleigh has 48 hits with 10 doubles, a team-high 17 home runs, and 35 RBIs. Randy Arozarena has 42 hits with 11 doubles, 6 home runs, 21 RBIs, and 9 stolen bases. Julio Rodriguez also has 49 hits with a pair of triples, 9 home runs, 29 RBIs, and 6 stolen bases. Dylan Moore has 8 homers and 8 stolen bases as well this season. Rowdy Tellez has also added 8 home runs and 23 RBIs, while J.P. Crawford has 45 hits with 5 doubles, 4 home runs, and 19 RBIs.

Why the Seattle Mariners will win

• The Mariners have won each of their last six games against National League opponents.
• The Nationals have lost eight of their last nine games against American League opponents that held a winning record.
• The Nationals have failed to cover the run line in seven of their last eight games against American League opponents that held a winning record.
• The Mariners have covered the run line in each of their last seven Wednesday home games.

Seattle Mariners Player Prop Facts

• Cal Raleigh has hit at least one home run in four of the Mariners’ last five games against NL opponents.
• Cal Raleigh has recorded at least one RBI in each of the Mariners’ last five games against NL opponents.
• J.P. Crawford has scored at least one run in each of the Mariners’ last seven night games against NL East opponents that held a losing record.
• George Kirby has recorded six or more strikeouts in five of his last six home appearances against opponents that held a losing record.
• J.P. Crawford has recorded at least one Single in each of the Mariners’ last eight games as favorites against NL opponents.
• Jorge Polanco has recorded at least one hit in each of his last nine home appearances against NL East opponents that held a losing record.
• George Kirby has recorded a win in each of his last five appearances against opponents that held a losing record.
• Cal Raleigh ranks 2nd in the league in Home Runs (19) this season.

Total Runs Facts

• Each of the Mariners’ last nine games as home favorites have gone OVER the total runs line.
• Twelve of the Nationals’ last 14 night games against American League opponents have gone UNDER the total runs line.

Washington Nationals vs. Seattle Mariners Prediction

I’m on the over here. Trevor Williams has not looked good in his action to this point, and in fairness, George Kirby, while one of the better arms in this Seattle rotation, hasn’t either, and that goes back to his rehab starts to rejoin the club. The Nationals’ offense has been inconsistent, but I think they can get to Kirby, and the Mariners can get to Williams for a couple. Once the bullpens have their say, I think we get up and over this number.