Sep 6, 2025; Chicago, Illinois, USA; Washington Nationals left fielder Daylen Lile (51) celebrates with teammates in the dugout after hitting a solo home run against the Chicago Cubs during the fourth inning at Wrigley Field. Mandatory Credit: Kamil Krzaczynski-Imagn Images

Washington Nationals vs Chicago Cubs Prediction 9/7/2025 Today’s MLB Picks

Pick details

Washington (57-84) vs Chicago (81-61)

September 7, 2025 at 02:20 PM EDT

The Line: Betting Odds: Chicago -1.5 — Over/Under: +8.5

(Get latest betting odds)

The Washington Nationals and Chicago Cubs meet Sunday in MLB action at Wrigley Field. Here’s a Washington Nationals vs Chicago Cubs Prediction. This article will include a Washington Nationals vs Chicago Cubs Pick.

Washington Nationals Betting Preview

The Washington Nationals are 57-84 on the year and play the Marlins, Pirates, and Braves next. The Washington Nationals are batting .243 on the season, have a .307 OBP, and a .386 slugging percentage. The Washington Nationals pitching staff has a 5.30 ERA and a 1.43 WHIP. James Wood leads the Washington Nationals with 35 hits and 86 RBI, while CJ Abrams and Luis Garcia Jr. have combined for 245 hits and 113 RBI.

Andrew Alvarez gets the ball for the Washington Nationals, and he is 1-0 with a 0.00 ERA and 4 strikeouts this season. This will be Alvarez’s first career game against the Chicago Cubs.

Chicago Cubs Betting Preview

The Chicago Cubs are 81-61 on the year and play the Braves, Rays, and Pirates next. The Chicago Cubs are batting .249 on the season, have a .320 OBP, and a .428 slugging percentage. The Chicago Cubs pitching staff has a 3.87 ERA and a 1.20 WHIP. Nico Hoerner leads the Chicago Cubs with 149 hits and 56 RBI while Pete Crow-Armstrong and Kyle Tucker have combined for 265 hits and 128 RBI.

Drew Pomeranz gets the ball for the Chicago Cubs, and he is 2-1 with a 2.45 ERA and 42 strikeouts this season. Pomeranz is 2-1 with a 3.00 ERA and 24 strikeouts in his career against the Washington Nationals.

Washington Nationals @ the Chicago Cubs Betting Trends: September 7, 2025

  • Probable Starting Pitcher: Drew Pomeranz      Record this season: 2-1      ERA: 2.40
  • Home Record: 1-1
  • Last 5 against Nationals: 0-0

Why the Chicago Cubs will win

  • The Nationals have lost each of their last six games at Wrigley Field following a win.
  • The Cubs have won each of their last six day games at Wrigley Field following a home loss.
  • The Nationals have failed to cover the run line in each of their last six games at Wrigley Field following a win.
  • The Cubs have covered the run line in each of their last six day games at Wrigley Field following a home loss.
  • The Cubs have led after 5 innings in three of their last four games.
  • The Cubs have led after 3 innings in three of their last four home games.
  • Probable Starting Pitcher: Andrew Alvarez      Record this season: 1-0      ERA: 0.00
  • Road Record: 0-0
  • Last 5 against Cubs: –

Why the Washington Nationals will win

  • The Nationals have won four of their last five games.
  • The Cubs have lost six of their last eight Sunday games as favorites against NL East opponents.
  • The Cubs have failed to cover the run line in each of their last six games as favorites after playing the previous day.
  • The underdogs have covered the run line in seven of the Cubs’ last eight games at Wrigley Field.
  • The Cubs have trailed after 5 innings in three of their last four home day games.

Total Runs Facts

  • Four of the Nationals’ last five road games against NL Central opponents have gone OVER the total runs line.
  • Four of the Cubs’ last five home games after playing the previous day have gone UNDER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Nationals’ last five games against NL Central opponents.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the last six games between the Nationals and Cubs.

Chicago Cubs Player Prop Facts

  • Ian Happ has hit a home run in three of the Cubs’ last four day games against opponents that held a losing record.
  • Ian Happ has recorded at least one hit in 10 of his last 11 appearances against NL opponents.

Washington Nationals Player Prop Facts

  • Luis Garcia has hit a home run in each of his last three road appearances with the Nationals against NL opponents.
  • CJ Abrams has recorded at least one hit in each of his last 10 road appearances against NL Central opponents that held a winning record.

Matchup/League Facts

  • The Cubs rank 4th in the league for strikeouts against this season (1099).
  • The Cubs rank 27th in the league for strikeouts this season (1089).
  • The Nationals rank 29th in the league for hits allowed this season (1282).
  • The Nationals rank 29th in the league for runs allowed this season (770).

Washington Nationals vs Chicago Cubs Prediction

Alvarez looked great in his MLB opener, holding the Marlins to 1 hit and 0 runs in 5 frames. However, it was just one game and it was at home. The jury is still out. We’ll learn more about Alvarez in a spot like this on the road. The Cubs have done a good job this week rebounding from a loss, and they are the better team no matter how you slice it. Pomeranz doesn’t move the needle because he’s going to go 1 inning at best. Still, I’ll lean Cubs at home on Sunday.

Randy Chambers's Pick: Chicago Cubs

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