Tampa Bay Rays vs Cleveland Guardians Prediction 8/25/2025 Today’s MLB Picks

The Tampa Bay Rays and the Cleveland Guardians meet Monday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Tampa Bay Rays vs. Cleveland Guardians prediction.

Starting Pitching Matchup

The Tampa Bay Rays will send out Ian Seymour for the start here and Seymour is 1-0 with a 3.86 ERA and 26 strikeouts this season. This will be Seymour’s first career start against the Guardians. Tanner Bibee will get the nod for the Guardians here and is 9-9 with a 4.62 ERA and 129 strikeouts this season. In his career, Bibee is 1-1 with a 3.46 ERA and 14 strikeouts against the Rays.

Tampa Bay Rays Recap

The Tampa Bay Rays come into this game looking to add on to their win over the St. Louis Cardinals from Sunday’s series finale to sit at 63-67 this season. After this series, the Rays will head on the road for a series against the Washington Nationals.

Rays Win Back-To-Back Games

Jonathan Aranda has 113 hits with 22 doubles, 12 home runs and 54 RBIs. Brandon Lowe has 107 hits with 25 homers and 63 RBIs as well while Junior Caminero has 124 hits with 21 doubles, a team-high 37 home runs and 91 RBIs. Yandy Diaz has 135 hits with 22 doubles, 21 homers and 73 RBIs.

Why the Tampa Bay Rays will win

• The Guardians have lost five of their last six games as favorites after playing the previous day.
• The underdogs have won four of the Guardians’ last five games at Progressive Field.
• The Rays have covered the run line each of their last six road games against AL Central opponents that held a losing record.
• The Guardians have failed to cover the run line in eight of their last nine home games against teams that held a losing record.

Tampa Bay Rays Player Prop Facts

• Josh Lowe has recorded a Double in each of his last three road appearances against AL opponents.
• Brandon Lowe has hit a home run in three of the Rays’ last four night games against AL opponents that held a losing record.
• Yandy Diaz has recorded at least one hit in each of his last nine appearances in night games against teams that held a losing record.
• Chandler Simpson ranks 2nd in the league in Steals (38) this season.

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to bounce back from their 5-0 loss at the hands of the Rangers in Sunday’s series finale to drop to 64-65 this season. After this series, the Guardians will take on the Seattle Mariners in a series at home.

Guardians Lose Five In A Row

Steven Kwan has 134 hits as part of a .275 batting average and 10 home runs, 22 doubles and 40 RBIs. Kyle Manzardo has 83 hits with 14 doubles, 2 triples, 21 home runs and 55 RBIs as well this year. Gabriel Arias has 20 doubles but also 121 strikeouts and Manzardo has 105 strikeouts so far this season. Arias has also added 9 home runs and 45 RBIs and Jose Ramirez has chipped in 26 home runs and 68 RBIs with 36 stolen bases as well. Carlos Santana has also added 89 hits with 11 home runs and 52 RBIs as well this season.

Why the Cleveland Guardians will win

• The Rays have lost each of their last 10 games as underdogs against American League opponents following a win.
• The home team has won each of the Guardians’ last five games.
• The Rays have failed to cover the run line in seven of their last eight games as underdogs after playing the previous day.
• The Guardians have covered the run line in five of their last six games against the Rays following a road loss.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in each of the Guardians’ last two home games against AL opponents.
• Carlos Santana has recorded at least one hit in each of his last eight home appearances against the Rays.
• Will Brennan has recorded at least one Double in each of his last three appearances with the Guardians as favorites against AL opponents.
• Jose Ramirez ranks 3rd in the league in Steals (36) this season.

Total Runs Facts

• Each of the last eight games between the Rays and Guardians have gone UNDER the total runs line.
• Each of the Rays’ last seven games as underdogs against the Guardians have gone UNDER the total runs line.

Tampa Bay Rays vs. Cleveland Guardians Prediction

I’m going to back the Rays here. The Guardians continue to struggle, and it’s just hard to feel good about the direction that the Guardians are headed in in their current form. Cleveland continues to look like the Guardians that struggled their way through the earlier part of the season, and the offense has fallen off of a cliff in recent games. The Rays aren’t going to be part of the postseason I’m guessing, but they’re still competitive and Bibee’s been giving up runs for Cleveland left and right this season. I’ll side with the Rays here.