Tampa Bay Rays vs Baltimore Orioles Prediction 9/23/2025 Today’s MLB Picks

The Tampa Bay Rays and Baltimore Orioles meet on Tuesday in MLB action from Oriole Park at Camden Yards. Here’s a Tampa Bay Rays vs Baltimore Orioles prediction. We will look at this from a betting perspective and determine the best Rays vs Orioles pick. We will examine:

The Tampa Bay Rays’ recent form and player performance

The Baltimore Orioles’ recent form and player performance

Recent betting trends and streaks involving the Rays

Recent betting trends and streaks involving the Orioles

Recent betting trends in games played between the Rays and Orioles

A summary that ties it all together and produces a favorable betting outcome for the Rays and Orioles game.

Too Little Too Late for the Rays

The Rays were able to pick up a win on Sunday, but it’s really too little too late at this point in terms of making the playoffs. On Sunday, the Rays scored seven runs, and that was enough to pick up for the four-run victory. Christopher Morel had a huge game, finishing with two hits and four runs driven in. Joe Boyle got the stat and he went 4.1 innings, giving up four hits and one run. He did have four walks which need to be better, but he also had nine strikeouts. 

The Rays are averaging 4.46 runs per game while their pitching is giving up 4.15 runs per game. The offense is ranked 15th, while the pitching is ranked 10th. Junior Caminero is having a huge season and has hit 44 home runs and driven in 108 RBIs. Ryan Pepiot gets the start for the Rays and he sits with an 11-11 record and an ERA of 3.37. In his last start he went 1.2 innings giving up four hits and four runs. In his previous three starts though, he had gone 15 innings total and didn’t give up a run. 

Bad Season for the Orioles

Coming into the season, many believed this Orioles squad was a World Series contender, but they have been nothing but a major disappointment. The Orioles scored only one run on Sunday against the New York Yankees, and they ended up losing by six runs. Samuel Bassallo hit a home run, and that was the only bright spot for the offense. Kyle Bradish was on the mound and he went six innings giving up only two hits and one run. The bullpen though struggled, and Keegan Akin went 0.1 innings giving up three hits and three runs. 

The Orioles are averaging 4.21 runs while their pitching is giving up 4.87 runs per game. The offense is ranked 24th in baseball, while the pitching is ranked 24th. One issue for this team all season has been injuries and catcher Adley Rutschman is dealing with an abdominal injury. 

Tampa Bay Rays vs Baltimore Orioles Prediction

Give me the Rays to get the job done here. Tampa Bay’s offense was good on Sunday, but it’s going to be the pitching that ends up being the difference in this game. Pepiot wasn’t great in his last start, but let’s not forget what he was able to do in the three starts before that. The Orioles offense has been bad most of the season, and this is going to be a game where they are going to really struggle again here. The Orioles won’t score more than two runs here, and that won’t be enough. Back Tampa Bay on the money line to cash here.