St. Louis Cardinals vs San Francisco Giants Prediction 9/9/2026 Today’s MLB Picks

The St. Louis Cardinals and the San Francisco Giants meet Wednesday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a St. Louis Cardinals vs. San Francisco Giants prediction.

Starting Pitching Matchup

The St. Louis Cardinals will send out Andre Pallante for the start here and Pallante is 12-6 with a 3.51 ERA and 98 strikeouts this season. Blade Tidwell will start for the Giants and is 0-2 with a 4.43 ERA and 36 strikeouts this season.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to bounce back from a 2-1 loss at the hands of the Giants on Tuesday to slip to 72-74 this season. After this series, the Cardinals will head home for a series against the Chicago White Sox.

Cardinals Drop Back-To-Back Games

Jordan Walker has 156 hits, 32 doubles, 28 home runs and 100 RBIs while Alec Burleson has 155 hits with 34 doubles, 21 home runs and 103 RBIs. JJ Wetherholt has 122 hits with 17 home runs and 48 RBIs while Ivan Herrera has 136 hits with 25 doubles, 16 home runs and 64 RBIs. Masyn Winn’s added 103 hits with 19 doubles and 51 RBIs and Nathan Church has 91 hits with 10 home runs and 48 RBIs this season. 

San Francisco Giants Recap

The San Francisco Giants come into this game looking to add on to their win over the Cardinals from Tuesday to sit at 61-85 on the year. After this series, the Giants will take on the San Diego Padres in a series at home.

Giants Looking For Sweep

Willy Adames has 107 hits with 25 doubles, 21 home runs and 51 RBIs along with 139 strikeouts. Matt Chapman has 72 hits with 18 doubles, a triple, 7 home runs and 42 RBIs and Jung Hoo Lee has 139 hits with 28 doubles, 4 triples, 9 home runs and 53 RBIs. Rafael Devers also has 140 hits with 34 doubles, 35 home runs and 91 RBIs but also has 158 strikeouts this season.

St. Louis Cardinals @ San Francisco Giants Betting Trends: September 9, 2026

• Probable Starting Pitcher: Blade Tidwell      Record this season: 0-2      ERA: 4.43
• Home Record: 0-1
• Last 5 against Cardinals: 0-1

Why the San Francisco Giants will win

• The Giants have won each of their last five games as underdogs against the Cardinals following a win.
• The Cardinals have lost each of their last five Wednesday games as favorites against NL West opponents.
• The underdogs have covered the run line in each of the last 11 games between the Cardinals and Giants.
• The Cardinals have failed to cover the run line in 19 of their last 22 games as favorites against NL West opponents.
• The Giants have led after 3 innings in five of their last six home games against NL Central opponents.
• The Giants have led after 5 innings in each of their last six home games against opponents that held a losing record.
• The Cardinals have lost the first inning in four of their last five games.

• Probable Starting Pitcher: Andre Pallante      Record this season: 12-6      ERA: 3.51
• Road Record: 7-0
• Last 5 against Giants: 1-0

Why the St. Louis Cardinals will win

• The Giants have lost each of their last eight day games following a win.
• The Cardinals have won 13 of their last 16 day games against the Giants following a loss.
• The Giants have failed to cover the run line in each of their last eight day games against NL Central opponents following a home win.
• The Cardinals have covered the run line in seven of their last eight day games against the Giants following a loss.
• The Cardinals have led after 3 innings in four of their last five road day games.
• The Cardinals have led after 5 innings in each of their last six road day games.

Total Runs Facts

• Each of the Cardinals’ last four day games against NL West opponents have gone OVER the total runs line.
• Each of the Giants’ last three games as underdogs against the Cardinals have gone UNDER the total runs line.
• There has been at least one run scored in the first inning in each of Blade Tidwell’s last six appearances as a starter.
• There has been at least one run scored in the first inning in seven of the Cardinals’ last eight day games against NL opponents.

San Francisco Giants Player Prop Facts

• Rafael Devers has hit a home run in four of the Giants’ last five home games against opponents that held a losing record.
• Blade Tidwell has recorded five or more strikeouts in three of his last four appearances with the Giants as underdogs.
• Drew Gilbert has recorded at least one hit in each of his last eight home appearances against NL opponents that held a losing record.
• Rafael Devers ranks 8th in the league in Home Runs (35) this season.

St. Louis Cardinals Player Prop Facts

• Alec Burleson has hit a home run in two of the Cardinals’ last three day games against NL West opponents that held a losing record.
• Andre Pallante has recorded five or more strikeouts in seven of his last eight appearances against opponents that held a losing record.
• Ivan Herrera has recorded at least one hit in each of the Cardinals’ last 15 games against NL West opponents that held a losing record.
• Jordan Walker ranks T8th in the league in Hits (157) this season.

Matchup/League Facts

• The Giants rank 1st in the league for home runs allowed this season (139).
• The Giants rank 29th in the league for walks this season (405).
• The Cardinals rank 26th in the league for slugging percentage this season (.385).
• The Cardinals rank 26th in the league for opponent batting average this season (.254).

St. Louis Cardinals vs. San Francisco Giants Prediction

I’m backing St. Louis in this one. I think it’s truly imperative that the Cardinals avoid a sweep here despite their playoff hopes fading day-by-day and Pallante has been one of their better options in the starting rotation this season. I’m still not sold on Blade Tidwell’s game if I’m being honest, and I think St. Louis takes care of business in this one to salvage something from the series. Give me St. Louis here.

Chris Ruffolo's Pick: St. Louis -125