St. Louis Cardinals vs San Francisco Giants Prediction 9/24/2025 Today’s MLB Picks

The St. Louis Cardinals and the San Francisco Giants meet Wednesday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a St. Louis Cardinals vs. San Francisco Giants prediction.

Starting Pitching Matchup

The St. Louis Cardinals will send out Sonny Gray for the start here and Gray is 14-8 with a 4.33 ERA and 194 strikeouts this season. In his last five starts against the Giants, Gray is 2-1 with a 3.29 ERA and 27 strikeouts. Robbie Ray will get the nod for the Giants here and is 11-8 with a 3.65 ERA and 186 strikeouts this season. In his last five starts against the Cardinals, Ray is 2-2 with a 3.38 ERA and 31 strikeouts.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to add on to their 9-8 win over the Giants from Tuesday’s matchup to improve to 78-80 this season. After this series, the Cardinals will take to the road for a series against the Chicago Cubs.

Cardinals Win Three In A Row

Brendan Donovan has 127 hits along with 27 doubles, 10 home runs and 48 RBIs while Lars Nootbaar has 117 hits with 13 home runs, 48 RBIs, 23 doubles and 4 stolen bases. Nolan Arenado also has 91 hits with 18 doubles, 10 home runs and 49 RBIs of his own and Victor Scott II has 82 hits with 14 doubles, a triple, 37 RBIs and a team-high 33 stolen bases. Willson Contreras has also chipped in 126 hits with 31 doubles, 20 home runs and 80 RBIs of his own as well this season. Masyn Winn’s added 124 hits with 27 doubles, 9 home runs and 51 RBIs and Alec Burleson’s added 141 hits with 25 doubles, 18 home runs and 67 RBIs.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to bounce back from their loss at the hands of the Cardinals in Tuesday’s matchup to sit at 77-81 on the year. After this set, the Giants will take on the Colorado Rockies in a division series at home.

Giants Lose 9 Of Their Last 11

Jung Hoo Lee has 141 hits including a team-high 30 doubles along with 11 triples, 8 home runs and 52 RBIs with 10 stolen bases while Heliot Ramos has 154 hits with 24 doubles, 19 home runs and 65 RBIs. Wilmer Flores also has 16 home runs and 71 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 102 hits with 21 home runs and 60 RBIs along with 21 doubles and Willy Adames has 128 hits with 21 doubles, 28 home runs and 83 RBIs of his own this season. 

St. Louis Cardinals @ San Francisco Giants Betting Trends: September 24, 2025

• Probable Starting Pitcher: Robbie Ray      Record this season: 11-8      ERA: 3.65
• Home Record: 5-4
• Last 5 against Cardinals: 2-2

Why the San Francisco Giants will win

• The Cardinals have lost each of their last eight Wednesday games against National League opponents that held a losing record.
• The Giants have won nine of their last 10 Wednesday night games against NL Central opponents that held a losing record.
• The Cardinals have failed to cover the run line each of their last eight Wednesday games against National League opponents that held a losing record.
• The Giants have covered the run line in each of their last six Wednesday games against the Cardinals.
• The Giants have won the first inning in four of their last five night games at Oracle Park.
• The Giants have led after 5 innings in five of their last six night games against NL Central opponents.
• The Cardinals have trailed after 3 innings in seven of their last eight road games against NL West opponents that held a losing record.

• Probable Starting Pitcher: Sonny Gray      Record this season: 14-8      ERA: 4.33
• Road Record: 4-3
• Last 5 against Giants: 2-1

Why the St. Louis Cardinals will win

• The Giants have lost each of their last eight games as favorites against National League opponents following a home loss.
• The Cardinals have won each of their last four games as underdogs against the Giants.
• The Giants have failed to cover the run line in each of their last 12 games as favorites against National League opponents following a home loss.
• The Cardinals have covered the run line in each of their last nine games as underdogs against the Giants.
• The Cardinals have led after 3 innings in each of their last five Wednesday night games against NL West opponents that held a losing record.
• The Cardinals have won the first inning in three of their last four night games at Oracle Park.
• The Cardinals have led after 5 innings in four of their last five games.

Total Runs Facts

• Nine of the Giants’ last 10 home games after playing the previous day have gone OVER the total runs line.
• Five of the Cardinals’ last six road games against National League opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in nine of the Giants’ last 10 night games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last four night games at Oracle Park.

San Francisco Giants Player Prop Facts

• Jung Hoo Lee has recorded at least one hit in each of his last 11 appearances in night games against teams that held a losing record.
• Heliot Ramos has hit a home run in three of the Giants’ last four home games against NL Central opponents.
• Matt Chapman has recorded a Double in three of the Giants’ last four night games against opponents that held a losing record.

St. Louis Cardinals Player Prop Facts

• Sonny Gray has recorded six or more strikeouts in each of his last seven appearances in night games.
• Willson Contreras has hit a home run in three of his last four road appearances against opponents that held a losing record.
• Brendan Donovan has recorded at least one Double in four of his last five appearances in night games against NL West teams that held a losing record.
• Masyn Winn has recorded at least one hit in each of his last 13 road appearances against NL West opponents that held a losing record.
• Victor Scott II ranks T10th in the league in Steals (33) this season.

Matchup/League Facts

• The Giants rank 1st in the league for home runs allowed this season (139).
• The Giants rank 29th in the league for steals this season (68).
• The Cardinals rank 30th in the league for triples this season (8).
• The Cardinals rank 29th in the league for strikeouts this season (1176).

St. Louis Cardinals vs. San Francisco Giants Prediction

I’m taking St. Louis here. I haven’t been the biggest fan of St. Louis over the course of the second half of hte season, but there’s no denying that they’ve been the better team in this series, and the Giants just look like a team that’s waved the white flag on the season. I think the value here is on St. Louis so I’ll side with the Cardinals in this one.