St. Louis Cardinals vs San Diego Padres Prediction 08/03/2025 Today’s MLB Picks

In this article, we will formulate a Cardinals vs Padres prediction for this MLB game on Sunday, August 3, at PETCO Park in San Diego, California. Let’s take a look at the prediction for this MLB matchup.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals (56-56, 24-32 Away) are looking for the first series win in the second half of the season. After getting swept by the Diamondbacks, the Cardinals lost to the Rockies, split with the Padres, and lost to the Marlins. They also lost Game 1 of the current series against the Padres, but answered with an 8-5 victory on Saturday. Pedro Pages led the offense with three RBI, while Michael McGreevy got the win after allowing four runs on seven hits with four strikeouts and one walk in 6.0 innings.

This year, the Cardinals average 4.36 runs per game (14th in the MLB) on a .249/.319/.388 triple-slash. When it comes to pitching, the Cardinals’ staff has a 4.17 ERA (19th) and 1.28 WHIP (17th). Willson Contreras leads the Cardinals with a .257 batting average, 15 home runs, and 63 RBI this season.

The projected starting pitcher for the Cardinals is Andre Pallante, who is 6-7 in 21 starts this season, with a 4.62 ERA and 1.31 WHIP in 117.0 innings.

San Diego Padres Betting Preview

The San Diego Padres (61-50, 35-19 Home) were on a six-game winning run but couldn’t make it seven in a row after losing to the Cardinals 8-5. Before this loss, the Padres beat the Cards in b2b games and then swept the New York Mets. In last night’s defeat, Freddy Fermin led the offense with two RBI, while Randy Vasquez took the loss after allowing five runs on eight hits with three strikeouts and no walks in 4.0 innings.

This season, the Padres average 4.08 runs per game (24th in the MLB) on a .250/.318/.378 triple-slash. When it comes to pitching, the Padres’ staff has a 3.52 ERA (3rd) and 1.21 WHIP (4th). Manny Machado leads the Padres with a .301 batting average, 20 home runs, and 72 RBI this season.

Dylan Cease will take the mound for the Padres on Sunday. The 29-year-old right-hander has a 3-10 record in 22 starts this year with a 4.79 ERA and 1.34 WHIP in 118.1 innings.

Total Runs Facts

• Six of the Cardinals’ last eight day games against National League opponents have gone OVER the total runs line.
• Three of the Padres’ last four games have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the last eight day games between the Cardinals and Padres at Petco Park.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last four day games at Petco Park.

Matchup/League Facts

• The Padres rank 2nd in the league for opponent batting average this season (.227).
• The Padres rank 3rd in the league for strikeouts against this season (776).
• The Cardinals rank 3rd in the league for doubles this season (198).
• The Cardinals rank 3rd in the league for walks allowed this season (292).

Cardinals vs Padres Prediction

The teams have traded victories in the past couple of years, each recording five in the previous ten H2H encounters. This season, the series is tied at 3-3. I am pleasantly surprised with a relatively low run total, so I have to exploit this opportunity and back Over. Andre Pallante did record a shutout against the Marlins in his latest start, but he allowed 17 runs in three starts before that one and posted a 5.16 ERA in July. Dylan Cease, on the other hand, surrendered multiple runs in five of his previous six starts, and he registered a 5.67 ERA in July. I am backing both offenses to have success early on, and I’ll go with Over.