Aug 5, 2025; Los Angeles, California, USA; Los Angeles Dodgers designated hitter Shohei Ohtani (17) looks on from the dugout during the ninth inning against the St. Louis Cardinals at Dodger Stadium. Mandatory Credit: William Liang-Imagn Images

St. Louis Cardinals vs Los Angeles Dodgers Prediction 08/06/2025 Today’s MLB Picks

Pick details

St. Louis (57-58) vs Los Angeles (66-48)

August 6, 2025 at 04:10 PM EDT

The Line: Betting Odds: Los Angeles -204 / Saint Louis +181 — Over/Under: +9

(Get latest betting odds)

In this article, we will formulate a Saint Louis Cardinals vs Los Angeles Dodgers Prediction for this MLB game on Wednesday, August 6th at the Dodger Stadium in the third game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

Los Angeles Dodgers Preview

The Los Angeles Dodgers have a 66-48 record this season and are sitting on the first place of the NL West. The Dodgers have a 36-22 home record and 56-55 in over/under. They are coming off a 12-6 home victory over the Cardinals, and are 5-3 in their last 8 games. Under is 10-1-1 in their last 12 games, and are playing the Blue Jays and the Angels next.

The Dodgers have a .255 batting average this season, .329 OBP and .441 slugging percentage. LA’s pitching staff has a 4.16 ERA and 1.31 WHIP.  Sohei Ohtani leads the Dodgers with 121 hits, in RBI, with 73 and in home runs, with 38. Will Smith is the team’s best hitter with a .321 batting average.

Shohei Ohtani (R) is the projected starting pitcher for the Dodgers, and he has a 0-0 record, 2.40 ERA and 1.27 WHIP.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 57-58 record this season and are sitting on the 4th place of the NL Central. The Cardinals have a 25-34 road record and are 58-51 in over/under They are coming off a 6-12 road defeat by the Dodgers, and are 3-7 in their last 10 games. Over is 3-1 in their last 4 games and are playing the Rockies and the Cubs next.

The Cardinals have a .249 batting average this season, .318 OBP and .388 Slugging percentage. Saint Louis’ pitching staff has a 4.24 ERA and 1.29 WHIP. Brendan Donovan leads the Cardinals with 113 hits, and he is the team’s best hitter with a .279 batting average. Wilson Contreras leads the team in RBI, with 64, adding a team-high 16 home runs.

Matthew Liberatore (R) is the projected starting pitcher for the Cardinals, and he has a 6-9 record, 3.96 ERA and 1.28 WHIP.

Why the Los Angeles Dodgers will win

  • The Dodgers have won each of their last 12 day games against National League opponents that held a losing record.
  • The Cardinals have lost each of their last six day games against NL West opponents.
  • The Cardinals have failed to cover the run line in each of their last six day games against National League opponents.
  • The Dodgers have covered the run line each of their last five day games against National League opponents that held a losing record.
  • The Cardinals have trailed after 3 innings in five of their last six day games against NL West opponents.
  • The Cardinals have trailed after 5 innings in each of their last six day games against NL West opponents.

Why the St. Louis Cardinals will win

  • The Dodgers have lost each of their last four games as home favorites against National League opponents following a win.
  • The Cardinals have won four of their last five games as road underdogs against NL West opponents following a road loss.
  • The Dodgers have failed to cover the run line in each of their last six games as favorites following a win.
  • The Cardinals have covered the run line in 17 of their last 18 Wednesday games as road underdogs.

Total Runs Facts

  • Eight of the Dodgers’ last nine day games after playing the previous day have gone UNDER the total runs line.
  • Seven of the Cardinals’ last nine day games against National League opponents have gone OVER the total runs line.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Dodgers’ last six day games against National League opponents.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Cardinals’ last eight games.

Matchup/League Facts

  • The Dodgers rank 1st in the league for runs scored this season (590).
  • The Dodgers rank 1st in the league for RBIs this season (570).
  • The Cardinals rank 30th in the league for triples this season (4).
  • The Cardinals rank 29th in the league for strikeouts this season (833).

Saint Louis Cardinals vs Los Angeles Dodgers Prediction

The Cardinals are 3-2 in their 5 meetings against the Dodgers this season. Both teams are tied 2-2 wins in their last 4 meetings in Los Angeles, and under is 5-2 in their last 7 meetings.

In this Saint Louis Cardinals vs Los Angeles Dodgers Prediction, the Dodgers are coming as -210 home favorites. The Dodgers are rightfully favored, as they have a better overall record, and have been very strong at home, while Saint Louis has been terrible on the road. Liberatore has been better on the road for the Cardinals with a 3.52 road ERA, and he is coming off back-to-back quality starts with just one earned run in each. The Cardinals have a better bullpen, and the Dodgers have been weak against left-handed pitching, so I like the guests to keep this one close. Take the Saint Louis Cardinals by +1.5 runs in this one.

Nikos Lagouretos's Pick: Saint Louis Cardinals +1.5

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