Jun 8, 2025; St. Louis, Missouri, USA;  Los Angeles Dodgers designated hitter Shohei Ohtani (17) reacts after he was hit by a pitch by St. Louis Cardinals relief pitcher Matt Svanson (not pictured) during the eighth inning at Busch Stadium. Mandatory Credit: Jeff Curry-Imagn Images

St. Louis Cardinals vs Los Angeles Dodgers Prediction 08/04/2025 Today’s MLB Picks

Pick details

St. Louis (56-57) vs Los Angeles (65-47)

August 4, 2025 at 10:10 PM EDT

The Line: Betting Odds: Los Angeles -182 / Saint Louis +163 — Over/Under: +8

(Get latest betting odds)

In this article, we will formulate a Saint Louis Cardinals vs Los Angeles Dodgers Prediction for this MLB game on Monday, August 4th at the Dodger Stadium in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Los Angeles Dodgers Preview

The Los Angeles Dodgers have a 65-47 record this season and are sitting on the first place of the NL West. The Dodgers have a 35-21 home record and 55-54 in over/under. They are coming off 3-0 road victory over the Rays, and are 4-2 in their last 6 games. Under is 9-0-1 in their last 10 games, and are playing the Blue Jays and the Angels next.

The Dodgers have a .254 batting average this season, .329 OBP and .439 slugging percentage. LA’s pitching staff has a 4.17 ERA and 1.31 WHIP.  Sohei Ohtani leads the Dodgers with 118 hits, in RBI, with 73 and in home runs, with 38. Will Smith is the team’s best hitter with a .324 batting average.

Tyler Glasnow (R) is the projected starting pitcher for the Dodgers, and he has a 1-1 record, 3.38 ERA and 1.15 WHIP.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 56-57 record this season and are sitting on the 4th place of the NL Central. The Cardinals have a 24-33 road record and are 57-50 in over/under They are coming off a 3-7 road defeat by the Padres, and are 1-4 in their last 5 games. Under is 5-3-1 in their last 9 games and are playing the Rockies and the Cubs next.

The Cardinals have a .249 batting average this season, .319 OBP and .388 Slugging percentage. Saint Louis’ pitching staff has a 4.19 ERA and 1.29 WHIP. Brendan Donovan leads the Cardinals with 112 hits, while Alec Burleson is the team’s best hitter with a .284 batting average. Wilson Contreras leads the team in RBI, with 63, adding a team-high 15 home runs.

Sonny Gray (R) is the projected starting pitcher for the Cardinals, and he has a 10-5 record, 4.38 ERA and 1.22 WHIP.

Why the Los Angeles Dodgers will win

  • The Cardinals have lost eight of their last nine games at Dodger Stadium.
  • The Dodgers have won eight of their last nine home games against NL Central opponents that held a losing record.
  • The Dodgers have covered the run line each of their last four games against National League opponents that held a losing record.
  • The Cardinals have failed to cover the run line in eight of their last 10 road games.
  • The Dodgers have led after 3 innings in five of their last six games at Dodger Stadium against NL Central opponents that held a losing record.
  • The Dodgers have led after 5 innings in eight of their last nine games against the Cardinals at Dodger Stadium.
  • The Dodgers have won the first inning in five of their last six home games against NL Central opponents that held a losing record.

Why the St. Louis Cardinals will win

  • The Dodgers have lost four of their last five games as favorites following a win.
  • The Cardinals have won seven of their last eight night games against NL West opponents following a loss.
  • The Cardinals have covered the run line in each of their last seven night games following a road loss.
  • The Dodgers have failed to cover the run line in each of their last six night games against NL Central opponents following a win.
  • The Cardinals have led after 3 innings in each of their last three night games against the Dodgers.
  • The Dodgers have trailed after 5 innings in four of their last five home games against National League opponents.

Total Runs Facts

  • Nine of the Dodgers’ last 10 games have gone UNDER the total runs line.
  • Three of the Cardinals’ last four games against NL West opponents have gone OVER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Dodgers’ last 11 Monday games.
  • The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Cardinals’ last seven night games.

Matchup/League Facts

  • The Dodgers rank 2nd in the league for home runs this season (164).
  • The Dodgers rank T2nd in the league for RBIs this season (556).
  • The Cardinals rank 30th in the league for triples this season (4).
  • The Cardinals rank 29th in the league for strikeouts this season (816).

Saint Louis Cardinals vs Los Angeles Dodgers Prediction

Both teams are tied 4-4 wins in their last 8 overall meetings, but the Cardinals have won their only series this season in Saint Louis with 2-1 wins. Under is 4-1 in their last 5 meetings.

In this Saint Louis Cardinals vs Los Angeles Dodgers Prediction, the Dodgersare coming as -185 home favorites. The Dodgers are rightfully favored, as they have a better overall record, and have been very strong at home, while the Cardinals have been struggling on the road. Glasnow has been better at home for the Dodgers with a 2.16 home ERA, while Gray has been weaker on the road for the Cardinals, with a 5.84 road ERA, and he is in terrible form lately, with an 8.44 ERA across his last 5 starts. The Dodgers also have the third-best offense in the league to provide Glasnow with run support, and are even better against right-handed pitching. Take the Los Angeles Dodgers to take care of business at home in this one.

Nikos Lagouretos's Pick: Los Angeles Dodgers -182

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