Seattle Mariners vs St. Louis Cardinals Prediction 4/26/2026 Today’s MLB Picks

The Seattle Mariners and the St. Louis Cardinals meet Sunday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Seattle Mariners vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Seattle Mariners will send out Emerson Hancock here and Hancock is 2-1 with a 2.83 ERA and 28 strikeouts this season. This will be Hancock’s first career start against St. Louis. Michael McGreevy will start for the Cardinals here and is 1-2 with a 3.29 ERA and 15 strikeouts this season. This will be McGreevy’s second career start against the Mariners.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to build on their 11-9 win over the Cardinals from Saturday’s matchup to improve to 13-15 this season. After this series, the Mariners will head on the road for a series against the Minnesota Twins.

Mariners Pick Up Back-To-Back Wins

Brendan Donovan has 17 hits with 3 doubles, 3 home runs and 8 RBIs while Luke Raley has 5 home runs and 13 RBIs this season. Cole Young’s added 25 hits with 3 doubles, a triple, 3 home runs and 13 RBIs and Cal Raleigh has 22 hits with 4 doubles, 5 home runs and 14 RBIs as well this season. Randy Arozarena has 29 hits with 8 doubles, 2 home runs and 11 RBIs as well on the year. Josh Naylor also has 21 hits with 3 home runs and 11 RBIs as well on the year. Julio Rodriguez has also added 27 hits with 3 doubles, 2 home runs and 10 RBIs.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to shake off their loss at the hands of Seattle on Saturday to sit at 14-12 on the year. After this series, St. Louis will take on the Pittsburgh Pirates on the road.

Cardinals Drop 3 In A Row

Jordan Walker leads the Cardinals with 27 hits, 4 doubles, 8 home runs and 16 RBIs while Alec Burleson has 25 hits with 6 doubles, 3 home runs and 17 RBIs. JJ Wetherholt has 23 hits with 4 home runs and 12 RBIs while Ivan Herrera has 22 hits with 4 doubles and 13 RBIs. Nolan Gorman has 19 hits with 3 home runs and 15 RBIs this season.

Seattle Mariners @ St. Louis Cardinals Betting Trends: April 26, 2026

• Probable Starting Pitcher: Michael McGreevy      Record this season: 1-2      ERA: 3.29
• Home Record: 0-0
• Last 5 against Mariners: 0-0

Why the St. Louis Cardinals will win

• The Mariners have lost seven of their last eight games as road favorites after playing the previous day.
• The Cardinals have won four of their last five games as underdogs against AL West opponents following a home loss.
• The Mariners have failed to cover the run line in seven of their last eight games as road favorites.
• The Cardinals have covered the run line in six of their last seven games against American League opponents.
• The Mariners have trailed after 3 innings in four of their last five day games against National League opponents that held a winning record.
• The Mariners have trailed after 5 innings in seven of their last eight games as road favorites.

• Probable Starting Pitcher: Emerson Hancock      Record this season: 2-1      ERA: 2.83
• Road Record: 0-1
• Last 5 against Cardinals: 1-0

Why the Seattle Mariners will win

• The Mariners have won each of their last six games against the Cardinals.
• The Cardinals have lost seven of their last eight day games against American League opponents following a loss.
• The Cardinals have failed to cover the run line in each of their last six day games against American League opponents following a home loss.
• The Mariners have covered the run line in each of their last six Sunday day road games against National League opponents.
• The Mariners have led after 3 innings in three of their last four games as road favorites against NL Central opponents.

Total Runs Facts

• Eight of the Cardinals’ last nine games as underdogs against American League opponents have gone OVER the total runs line.
• Five of the Mariners’ last six games as road favorites have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Mariners’ last six day games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the last five day games between the Mariners and Cardinals.

St. Louis Cardinals Player Prop Facts

• Masyn Winn has recorded at least one hit in each of his last 10 appearances.
• Ramon Urias has hit a home run in four of his last eight home appearances against AL West opponents.
• Jordan Walker ranks T9th in the league in Home Runs (8) this season.

Seattle Mariners Player Prop Facts

• Cal Raleigh has hit at least one home run in three of his last four appearances in day games against NL Central teams that held a winning record.
• Cal Raleigh has recorded at least one hit in each of his last 10 appearances in day games against NL Central teams that held a winning record.
• Randy Arozarena ranks T9th in the league in Steals (7) this season.

Matchup/League Facts

• The Cardinals rank 30th in the league for strikeouts this season (170).
• The Cardinals rank 27th in the league for doubles this season (34).
• The Mariners rank 1st in the league for walks allowed this season (66).
• The Mariners rank 26th in the league for strikeouts against this season (252).

Seattle Mariners vs. St. Louis Cardinals Prediction

I’m on the Mariners here. I’ve been impressed with Hancock’s stuff on the road and McGreevy for me is the weak link of this Cardinals rotation. I think that the Mariners complete the sweep as they’ve been finding ways to win as of late and I’ll back them at this price here. Give me Seattle.

Chris Ruffolo's Pick: Seattle -145