Jun 21, 2025; Chicago, Illinois, USA; Seattle Mariners catcher Cal Raleigh (29) is greeted in the dugout after hitting a home run against the Chicago Cubs during the ninth inning at Wrigley Field. Mandatory Credit: David Banks-Imagn Images

Seattle Mariners vs Chicago Cubs Prediction 06/22/2025 Picks

Pick details

Seattle (38-37) vs Chicago (46-30)

June 22, 2025 at 02:20 PM EDT

The Line: Betting Odds: Chicago +1.5 — Over/Under: +12

(Get latest betting odds)


The Seattle Mariners and Chicago Cubs meet Sunday in MLB action at Wrigley Field. Here’s a Seattle Mariners vs Chicago Cubs Prediction. This article will include a Seattle Mariners vs Chicago Cubs Pick.

Seattle Mariners Betting Preview

The Seattle Mariners are 38-37 on the year and play the Twins, Rangers, and Royals next. The Seattle Mariners are batting .245 on the season, have a .324 OBP, and a .401 slugging percentage. The Seattle Mariners pitching staff has a 3.96 ERA and a 1.29 WHIP. Julio Rodriguez leads the Seattle Mariners with 77 hits and 34 RBI, while Cal Raleigh and J.P. Crawford have combined for 149 hits and 93 RBI. 

Logan Gilbert gets the ball for the Seattle Mariners, and he is 1-2 with a 2.55 ERA and 54 strikeouts this season. This will be Gilbert’s second career game against the Chicago Cubs.

Chicago Cubs Betting Preview

The Chicago Cubs are 46-30 on the year and play the Cardinals, Astros, and Guardians next. The Chicago Cubs are batting .254 on the season, have a .325 OBP, and a .442 slugging percentage. The Chicago Cubs pitching staff has a 3.70 ERA and a 1.24 WHIP. Nico Hoerner leads the Chicago Cubs with 79 hits and 31 RBI while Pete Crow-Armstrong and Kyle Tucker have combined for 158 hits and 105 RBI.

Colin Rea gets the ball for the Chicago Cubs, and he is 4-2 with a 3.84 ERA and 52 strikeouts this season. Rea is 1-0 with a 5.51 ERA and 8 strikeouts in his career against the Seattle Mariners.

Why the Chicago Cubs will win

The Cubs have won six of their last seven games as underdogs against AL West opponents.
The Mariners have lost five of their last six games as road favorites after playing the previous day.
The Mariners have failed to cover the run line in each of their last eight games as road favorites.
The Cubs have covered the run line in six of their last seven games as underdogs against AL West opponents.
The Mariners have lost the first inning in each of their last three road games against NL Central opponents.
The Mariners have trailed after 3 innings in four of their last five games against National League opponents.
The Mariners have trailed after 5 innings in five of their last six road games against opponents that held a winning record.

Why the Seattle Mariners will win

The Mariners have won each of their last four road games against NL Central opponents following a loss.
The Cubs have lost four of their last five day games following a win.
The Cubs have failed to cover the run line in seven of their last eight games following a win.
The Mariners have covered the run line in each of their last four road games against NL Central opponents following a loss.
The Mariners have led after 5 innings in seven of their last eight Sunday day games as road favorites.

Chicago Cubs Player Prop Facts

Ian Happ has hit at least one home run in each of the Cubs’ last three home games against opponents that held a winning record.
Nico Hoerner has recorded at least one hit in each of his last 12 Sunday appearances at Wrigley Field.
Ian Happ has scored at least one run in each of the Cubs’ last seven games against opponents that held a winning record.
Ian Happ has recorded at least one RBI in six of the Cubs’ last seven day games against AL West opponents that held a winning record.
Kyle Tucker ranks 5th amongst qualified players for On Base Percentage (.395) this season.

Seattle Mariners Player Prop Facts

Cal Raleigh has hit at least one home run in each of the Mariners’ last four road games against NL Central opponents.
Logan Gilbert has recorded seven or more strikeouts in 12 of his last 13 appearances with the Mariners as favorites.
Randy Arozarena has recorded at least one hit in each of the Mariners’ last 10 road games against opponents that held a winning record.
Victor Robles has scored at least one run in seven of his last eight appearances with the Mariners as road favorites.
Cal Raleigh has recorded at least one RBI in each of the Mariners’ last seven road games against NL opponents that held a winning record.
Randy Arozarena has recorded at least one Double in each of his last four appearances at Wrigley Field against opponents that held a winning record.
Cal Raleigh ranks 2nd amongst qualified players for Slugging Percentage (.649) this season.

Seattle Mariners vs Chicago Cubs Prediction

The Cubs should get the benefit of the doubt at home as they continue to look like one of the best teams in the league. However, the Mariners have the edge on the mound for this game with Gilbert, who has a 2.55 ERA and 0.79 WHIP on the season. Gilbert has allowed three hits and two runs in his last eight innings. In 35.1 innings, Gilbert is allowing a .164 batting average and has 54 strikeouts. We’re seeing more and more why Gilbert was a highly touted prospect and somebody with legit ace potential. I love my aces and cheap prices. I’ll side with the Mariners.

Randy Chambers's Pick: Seattle Mariners

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