San Francisco Giants vs St. Louis Cardinals Prediction 9/7/2025 Today’s MLB Picks

In this article, we will formulate a Giants vs Cardinals Prediction for this MLB game on Sunday, September 7th at the Busch Stadium in the third game of this series, with both teams being tied 1-1 wins. Let’s take a look at the prediction for this MLB matchup.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 71-72 record this season and are sitting on the 4th place of the NL Central. The Cardinals have a 40-34 home record and are 72-63 in over/under. They are coming off a 3-2 home victory over the Giants, and are 3-1 in their last 4 games. Under is 3-1 in their last 4 games and are playing the Brewers and the Mariners next.

The Cardinals have a .246 batting average this season, .314 OBP and .382 Slugging percentage. Saint Louis’ pitching staff has a 4.28 ERA and 1.32 WHIP. Alec Burleson leads the Cardinals with 123 hits, and he is the team’s best hitter with a .286 batting average. Wilson Contreras leads the team in RBI, with 78, adding a team-high 20 home runs.

Sonny Gray (R) is the projected starting pitcher for the Cardinals, and he has a 12-8 record, 4.43 ERA and 1.23 WHIP.

San Francisco Giants Preview

The San Francisco Giants have a 72-70 record this season and are sitting on the third place of the NL West. They have a 37-36 road record and are 67-69 in over/under. They are coming off a 2-3 road defeat by the Cardinals, that ended their five-game winning streak. Over is 6-2 in their last 8 games and are playing the Dodgers and the Diamondbacks next.

The Giants have a .239 batting average this season, .314 OBP and .391 Slugging percentage. San Francisco’s pitching staff has a 3.76 ERA and 1.28 WHIP.  Heliot Ramos leads the Giants with 145 hits and is the team’s best hitter, with a .269 batting average. Willy Adames leads the team in RBI with 78, adding a team-high 27 home runs. 

Kai-Wei Teng (R) is the projected starting pitcher for the Giants, and he has a 2-3 record, 7.23 ERA and 1.71 WHIP.

San Francisco Giants @ St. Louis Cardinals Betting Trends: September 7, 2025

• Probable Starting Pitcher: Sonny Gray      Record this season: 12-8      ERA: 4.43
• Home Record: 8-5
• Last 5 against Giants: 1-1

Why the St. Louis Cardinals will win

• The Giants have lost each of their last six day games at Busch Stadium following a loss.
• The Cardinals have won each of their last five day games against the Giants at Busch Stadium following a win.
• The Cardinals have covered the run line in seven of their last eight games against the Giants.
• The Giants have failed to cover the run line in each of their last six games against the Cardinals following a loss.
• The Cardinals have led after 5 innings in nine of their last 10 day games against the Giants at Busch Stadium.
• The Cardinals have led after 3 innings in nine of their last 10 day games against the Giants at Busch Stadium.

• Probable Starting Pitcher: Kai-Wei Teng      Record this season: 2-3      ERA: 7.23
• Road Record: 1-2
• Last 5 against Cardinals: –

Why the San Francisco Giants will win

• The Cardinals have lost nine of their last 10 games as favorites following a win.
• The underdogs have won seven of the Cardinals’ last eight games.
• The Cardinals have failed to cover the run line in each of their last 13 games as favorites following a home win.
• The Giants have covered the run line in each of their last eight games as underdogs against NL Central opponents.
• The Cardinals have trailed after 5 innings in seven of their last eight day games against NL West opponents.
• The Giants have won the first inning in each of their last four day games.
• The Giants have led after 3 innings in five of their last six games.

Total Runs Facts

• Each of the Cardinals’ last eight games as favorites against the Giants have gone OVER the total runs line.
• Each of the Giants’ last five day games against NL Central opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Giants’ last four day games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the last six games between the Giants and Cardinals at Busch Stadium.

St. Louis Cardinals Player Prop Facts

• Sonny Gray has recorded a win in each of his last three home appearances against NL West opponents that held a winning record.
• Sonny Gray has recorded six or more strikeouts in each of his last eight Sunday appearances against teams that held a winning record.
• Brendan Donovan has hit a home run in three of his last six appearances against the Giants.
• Brendan Donovan has recorded at least one hit in each of his last nine appearances against the Giants.
• Victor Scott II ranks 10th in the league in Steals (31) this season.

San Francisco Giants Player Prop Facts

• Rafael Devers has hit a home run in four of his five previous road appearances against the Cardinals.
• Dominic Smith has recorded at least one Double in each of his last four appearances with his team as an underdog against the Cardinals.
• Dominic Smith has recorded at least one hit in each of his last 16 appearances against opponents that held a losing record.
• Rafael Devers ranks 9th amongst qualified players for On Base Percentage (.381) this season.

Matchup/League Facts

• The Cardinals rank T29th in the league for triples this season (7).
• The Cardinals rank 29th in the league for strikeouts this season (1055).
• The Giants rank 1st in the league for home runs allowed this season (123).
• The Giants rank 29th in the league for steals this season (63).

Giants vs Cardinals Prediction

The Cardinals are 6-2 in their last 8 head-to-head meetings against the Giants, and are 4-1 in their last 5 meetings in Saint Louis. Over is 8-2 in their last 10 meetings.

In this Giants vs Cardinals Prediction, the Cardinals are coming as -150 home favorites. I no way shape or form I am going to back Kai-Wei Teng to win on the road, even if the Giants are playing good baseball lately. Gray has been great at home for the Cardinals, with a 3.98 home ERA, and I expect the Cardinals to ride the momentum of yesterday’s win, and with a clear advantage on the mound, take care of business at home today.