San Francisco Giants vs San Diego Padres Prediction 8/19/2025 Today’s MLB Picks

In this article, we will formulate a Giants vs Padres Prediction for this MLB game on Tuesday, August 19th at the Petco Park in the second game of this series, with the Giants having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Preview

The San Diego Padres have a 69-56 record this season and are sitting on the second place of the NL West. They have a 38-21 home record, and are 51-70 in over/under. The Padres are coming off a 3-4 home defeat by the Giants, and have four consecutive losses. Under is 5-1-1 in their last 7 games and are playing the Dodgers and the Mariners next.

The Padres have a .251 batting average this season, .321 OBP and .383 Slugging percentage. San Diego’s pitching staff has a 3.58 ERA and 1.21 WHIP. Luis Arraez leads the Padres with 141 hits and team-high .291 batting average. Manny Machado leads the team in RBI, with 72, adding a team-high 20 home runs.

Nick Pivetta (R) is the projected starting pitcher for the Padres, and he has a 12-4 record, 2.87 ERA and 0.95 WHIP.

San Francisco Giants Preview

The San Francisco Giants have a 61-64 record this season and are sitting on the third place of the NL West. They have a 31-31 road record and are 57-63 in over/under. They are coming off a 4-3 road victory over the Padres, and have back-to-back wins. Under is 7-3-1 in their last 11 games and are playing the Cubs and the Brewers next.

The Giants have a .233 batting average this season, .309 OBP and .376 Slugging percentage. San Francisco’s pitching staff has a 3.67 ERA and 1.28 WHIP. Heliot Ramos leads the Giants with 128 hits and is the team’s best hitter, with a .267 batting average. Wilmer Flores leads the team in RBI with 63, while Willy Adames adds a team-high 19 home runs.

Kai-Wei Teng (R) is the projected starting pitcher for the Giants, and he has a 1-2 record, 9.90 ERA and 1.90 WHIP.

Why the San Diego Padres will win

• The Padres have won each of their last 10 home games following a home loss.
• The Giants have lost six of their last seven night games against the Padres following a win.
• The Padres have covered the run line in each of their last five night games against the Giants at Petco Park following a home loss.
• The Giants have failed to cover the run line in six of their last seven night games against the Padres following a win.
• The Giants have trailed after 5 innings in six of their last eight games as underdogs against NL West opponents.
• The Giants have lost the first inning in three of their last four night games at Petco Park.

Why the San Francisco Giants will win

• The Giants have won five of their last six games as road underdogs.
• The Padres have lost three of their last four games as home favorites against NL West opponents.
• The Padres have failed to cover the run line in eight of their last nine home games against National League opponents that held a losing record.
• The road team has covered the run line in seven of the last eight games between the Giants and Padres.
• The Padres have lost the first inning in four of their last five night games against National League opponents that held a losing record.
• The Giants have led after 3 innings in each of their last five road night games.
• The Giants have led after 5 innings in each of their last five road night games.

Total Runs Facts

• Each of the Padres’ last six night games against NL West opponents have gone UNDER the total runs line.
• Each of the Giants’ last four night games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Giants’ last seven night games at Petco Park.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Padres’ last five games as favorites against NL West opponents.

Matchup/League Facts

• The Padres rank 1st in the league for opponent batting average this season (.226).
• The Padres rank 1st in the league for hits allowed this season (923).
• The Giants rank 1st in the league for home runs allowed this season (108).
• The Giants rank T29th in the league for steals this season (56).

Giants vs Padres Prediction

The Padres are 8-3 in their last 11 meetings against the Giants, and are 2-1 in their last three meetings in San Diego. Under is 6-2 in their last 8 meetings.

In this Giants vs Padres Prediction, the Padres are coming as -235 home favorites. The Padres have a better overall record and have been very strong at home, and have a huge pitching advantage in this game, as Pivetta takes the mound. He has been excellent this season, even better at home, and in great form lately, with a 2.81 ERA in his last five starts. Kai-Wei Teng has been torched in his two starts this season, having given up 11 runs in just 4.3 innings pitched, and one of his two starts was against the Padres, who torced him for 6 runs. San Diego has the best bullpen in the league, and are hitting better righties, so I expect them to win comfortably in this one and cover the runline.