San Francisco Giants vs New York Yankees Prediction 4/13/25 MLB Picks

The San Francisco Giants and New York Yankees meet Sunday in MLB action at Yankee Stadium. Here’s a San Francisco Giants vs New York Yankees Prediction. This article will include a San Francisco Giants vs New York Yankees Pick.

San Francisco Giants Betting Preview

The San Francisco Giants are 10-4 on the year and play the Phillies, Angels, and Brewers next. The San Francisco Giants are batting .226 on the season, have a .305 OBP, and a .407 slugging percentage. The San Francisco Giants pitching staff has a 3.15 ERA and a 1.23 WHIP. Jung Hoo Lee leads the San Francisco Giants with 17 hits and 7 RBI, while Wilmer Flores and Heliot Ramos have combined for 27 hits and 28 RBI. 

Logan Webb gets the ball for the San Francisco Giants, and he is 1-0 with a 1.89 ERA and 21 strikeouts this season. Webb is 0-2 with a 5.54 ERA and 18 strikeouts in his career against the New York Yankees.

New York Yankees Betting Preview

The New York Yankees are 8-6 on the year and play the Royals, Rays, and Guardians next. The New York Yankees are batting .265 on the season, have a .348 OBP, and a .498 slugging percentage. The New York Yankees pitching staff has a 4.72 ERA and a 1.32 WHIP. Aaron Judge leads the New York Yankees with 19 hits and 20 RBI while Paul Goldschmidt and Ben Rice have combined for 32 hits and 10 RBI.

Carlos Rodon gets the ball for the New York Yankees, and he is 1-2 with a 5.19 ERA and 20 strikeouts this season. This will be Rodon’s first career game against the San Francisco Giants.

Why the New York Yankees will win

• The Yankees have won 10 of their last 12 games against the Giants.
• The Giants have lost five of their last six day games against AL East opponents.
• The Giants have failed to cover the run line each of their last eight Sunday games against AL East opponents that held a winning record.
• The Yankees have covered the run line in 12 of their last 14 games against the Giants.
• The Giants have trailed after 5 innings in four of their last five day games at Yankee Stadium against AL East opponents.
• The Giants have lost the first inning in three of their last four day games against AL East opponents.

Why the San Francisco Giants will win

• The Giants have won six of their last seven games as underdogs following a road loss.
• The Yankees have lost each of their last three games as home favorites against NL West opponents following a win.
• The Giants have covered the run line in 12 of their last 13 road games following a loss.
• The Yankees have failed to cover the run line in each of their last four home games against NL West opponents following a win.

San Francisco Giants vs New York Yankees Prediction

We’re getting the slightly more favorable price with a Giants team that continues to surprise with wins in 10 of their first 14 games. Rodon has also been hittable this season, allowing 11 hits and 10 earned runs through 17.1 innings. Webb is an all-star caliber pitcher who has allowed 15 hits and four runs through 19 innings while striking out 21. The Giants have played great ball up to this point and have the edge on the mound. Give me the road dog on Sunday afternoon.