Jul 7, 2024; Cleveland, Ohio, USA; Cleveland Guardians first baseman Josh Naylor (22) is tagged out at home plate by San Francisco Giants catcher Patrick Bailey (14) in the fourth inning at Progressive Field. Mandatory Credit: David Richard-Imagn Images

San Francisco Giants vs Cleveland Guardians Prediction 06/17/2025 Picks

Pick details

Cleveland (35-35) vs San Francisco (41-31)

June 17, 2025 at 09:45 PM EDT

The Line: Betting Odds: Cleveland +140 / San Francisco -165 — Over/Under: 7

(Get latest betting odds)

The Cleveland Guardians are visiting the San Francisco Giants on Tuesday, June 17th at the Oracle Park in the opening game of this series. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Cleveland Guardians vs San Francisco Giants Prediction. We will examine:
The San Francisco Giants recent form and player performance
The Cleveland Guardians recent form and player performance
Recent betting trends and streaks involving the San Francisco Giants
Recent betting trends and streaks involving the Cleveland Guardians
Recent betting trends in games played between the Cleveland Guardians vs San Francisco Giants
A summary that ties it all together and produces a favorable betting outcome for the Cleveland Guardians vs San Francisco Giants game

San Francisco Giants Preview

The San Francisco Giants have a 41-31 record this season and are sitting on the second place of the NL West. They have a 22-11 home record and are 34-36 in over/under. They are coming off a 4-5 road defeat by the Dodgers, and are 1-3 in their last 4 games. Over is 4-0-1 in their last 5 games, and are playing the Red Sox and the Marlins next.

The Giants have a .232 batting average this season, .311 OBP and .377 Slugging percentage. San Francisco’s pitching staff has a 3.27 ERA and 1.23 WHIP.  Heliot Ramos leads the Giants with 77 hits and is the team’s best hitter, with a .286 batting average. Wilmer Flores leads the team in RBI with 51, while Matt Chapman leads the team in home runs, with 12.

Robbie Ray (L) is the projected starting pitcher for the Giants, and he has an 8-1 record, 2.55 ERA and 1.12 WHIP. He has been better at home, with a 2.00 ERA across seven home starts, and he has given up two runs or less in nine of his ten starts this season. Robbie Ray has a 2-1 record with an ERA of 1.93 and 18 strikeouts in 5 appearances against the Guardians in his career.

Cleveland Guardians Preview

The Cleveland Guardians have a 35-35 record this season and are sitting on the third place of the AL Central. The Guardianshave a 16-20 road record and are 33-34 in over/under They are coming off a 0-6 road defeat by the Mariners, and are 2-8 in their last 10 games. Over is 3-1 in their last 4 games, and are playing the Blue Jays and the Athletics next.

The Guardians have a .232 batting average this season, .304 OBP and .374 Slugging percentage. Cleveland’s pitching staff has a 3.99 ERA and 1.38 WHIP. Jose Ramirez leads the Guardianswith 83 hits and a team-high .324 batting average, while leading the team in home runs, with 13. Carlos Santana leads the team in RBI, with 34.

Slade Cecconi (R) will take the mound for the Guardians, and he has a 1-3 record, 4.26 ERA and 1.34 WHIP. He has been better on the road with a 3.38 ERA across three road starts, and he is coming off a quality start against the Reds, with only one earned run in 5 innings of work. In his only previous start against the Giants back in 2023, he gave up two runs in 4.2 innings of work.

Why the San Francisco Giants will win

The Guardians have lost each of their last six night games against National League opponents.
The Giants have won each of their last six home games against American League opponents following a loss.
The Guardians have failed to cover the run line in seven of their last eight games as underdogs against NL West opponents.
The Giants have covered the run line in each of their last five games following a road loss.
The Guardians have trailed after 5 innings in each of their last eight games against NL West opponents that held a winning record.
The Guardians have trailed after 3 innings in four of their last five night games against NL West opponents that held a winning record.
The Giants have won the first inning in four of their last five night games.

Why the Cleveland Guardians will win

The Giants have lost six of their last seven games as favorites against AL Central opponents.
The underdogs have won six of the Giants’ last eight games at Oracle Park.
The underdogs have covered the run line in each of the Giants’ last 12 games at Oracle Park.
The Giants have failed to cover the run line in each of their last nine games as home favorites.
The Guardians have won the first inning in three of their last four games as underdogs against the Giants at Oracle Park.
The Giants have trailed after 5 innings in each of their last four games against American League opponents.
The Giants have trailed after 3 innings in six of their last seven games as favorites against AL Central opponents.

Total Runs Facts

Each of the Giants’ last seven night games against AL Central opponents have gone UNDER the total runs line.
Five of the Guardians’ last six games against National League opponents have gone OVER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Giants’ last six night games.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in eight of the Guardians’ last nine games as road underdogs against National League opponents.

Matchup/League Facts

The Giants rank 2nd in the league for home runs allowed this season (55).
The Giants rank 3rd in the league for ERA this season (3.27).
The Guardians rank 29th in the league for hits this season (528).
The Guardians rank T27th in the league for doubles this season (95).

Cleveland Guardians vs San Francisco Giants Prediction

The Giants are 7-3 in their last 10 meetings against the Guardians, and are 3-1 in their last 4 meetings in San Francisco. Over is 3-1 in their last 4 meetings.

In this Cleveland Guardians vs San Francisco Giants Prediction, the Giants are coming as -165 road favorites. The Giants are rightfully favored, as they have a better overall record, and have the second-fewest home losses in the National League. On the other hand, the Guardians are below average on the road, and the Giants have the best bullpen in the league. The Giants are better against righties, while the Guardians are weaker against lefties, and the Giants also have the pitching advantage, as Ray has been looking sharp throughout the season, while Cecconi is due to some negative regression, with a 5.87 expected ERA. Take the Giants to take care of business at home.

Nikos Lagouretos's Pick: San Francisco Giants -165

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