San Francisco Giants vs Chicago White Sox Prediction 06/27/2025 Picks

The San Francisco Giants and Chicago White Sox meet Friday in MLB action at Rate Field. Here’s a San Francisco Giants vs Chicago White Sox Prediction. This article will include a San Francisco Giants vs Chicago White Sox Pick.

San Francisco Giants Betting Preview

The San Francisco Giants are 44-37 on the year and play the Diamondbacks, Athletics, and Phillies next. The San Francisco Giants are batting .232 on the season, have a .313 OBP, and a .375 slugging percentage. The San Francisco Giants pitching staff has a 3.42 ERA and a 1.24 WHIP. Heliot Ramos leads the San Francisco Giants with 86 hits and 44 RBI, while Jung Hoo Lee and Wilmer Flores have combined for 141 hits and 88 RBI. 

Landen Roupp gets the ball for the San Francisco Giants, and he is 5-5 with a 3.67 ERA and 70 strikeouts this season. This will be Roupp’s first career game against the Chicago White Sox.

Chicago White Sox Betting Preview

The Chicago White Sox are 26-55 on the year and play the Dodgers, Rockies, and Blue Jays next. The Chicago White Sox are batting .220 on the season, have a .293 OBP, and a .345 slugging percentage. The Chicago White Sox pitching staff has a 4.18 ERA and a 1.40 WHIP. Miguel Vargas leads the Chicago White Sox with 67 hits and 34 RBI while Lenyn Sosa and Chase Meidroth have combined for 119 hits and 31 RBI.

Aaron Civale gets the ball for the Chicago White Sox, and he is 1-4 with a 5.03 ERA and 25 strikeouts this season. Civale is 3-1 with a 2.01 ERA and 19 strikeouts in his career against the San Francisco Giants.

Why the Chicago White Sox will win

The Giants have lost each of their last seven road games against American League opponents.
The underdogs have won five of the last six games between the Giants and White Sox at Rate Field.
The Giants have failed to cover the run line in each of their last 10 games as favorites against AL Central opponents following a loss.
The White Sox have covered the run line in seven of their last eight games as underdogs following a home win.

Why the San Francisco Giants will win

The White Sox have lost each of their last 10 night games against NL West opponents that held a winning record.
The Giants have won five of their last six games against AL Central opponents following a home loss.
The Giants have covered the run line in each of their last five road games following a loss.
The White Sox have failed to cover the run line each of their last five night games against National League opponents that held a winning record.
The Giants have led after 3 innings in each of their last three games as favorites against American League opponents.

Chicago White Sox Player Prop Facts

Andrew Benintendi has hit a home run in two of his last three home appearances against NL opponents that held a winning record.
Aaron Civale has recorded five or more strikeouts in each of his last five appearances with his team as an underdog against NL opponents.
Korey Lee has recorded at least one hit in each of his last six appearances against NL opponents that held a winning record.

San Francisco Giants Player Prop Facts

Dominic Smith has recorded a Double in each of his last three road appearances against AL opponents that held a losing record.
Heliot Ramos has hit a home run in three of his last four road appearances with the Giants against AL opponents.
Willy Adames has recorded at least one hit in each of his six previous appearances at Rate Field against opponents that held a losing record.

San Francisco Giants vs Chicago White Sox Prediction

The Giants have cooled off over the last few weeks, but this series is just what the doctor ordered. The White Sox remain a joke of a franchise and there’s zero betting value. Roupp has been respectable this season with a 3.67 ERA, and he’s coming off six shutout innings against the Red Sox. Civale has a 5.03 ERA and 1.47 WHIP on the season, and he’s allowed 15 hits and seven runs in 12 innings with the White Sox. This is a spot where the Giants should get back on track. Give me the road team on Friday night.